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PIKFYVE phosphoinositide kinase, FYVE-type zinc finger containing [ Ovis aries (sheep) ]

Gene ID: 101120727, updated on 6-Jun-2024

Summary

Gene symbol
PIKFYVE
Gene description
phosphoinositide kinase, FYVE-type zinc finger containing
See related
EnsemblRapid:ENSOARG00020017062
Gene type
protein coding
RefSeq status
MODEL
Organism
Ovis aries
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
Orthologs
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Genomic context

See PIKFYVE in Genome Data Viewer
Location:
chromosome: 2
Exon count:
45
Annotation release Status Assembly Chr Location
RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 2 NC_056055.1 (210348243..210428809)

Chromosome 2 - NC_056055.1Genomic Context describing neighboring genes Neighboring gene chromosome 2 C2orf80 homolog Neighboring gene isocitrate dehydrogenase (NADP(+)) 1 Neighboring gene male-specific lethal 3 homolog Neighboring gene parathyroid hormone 2 receptor

Genomic regions, transcripts, and products

Genomic Sequence:
NC_056055.1 Chromosome 2 Reference ARS-UI_Ramb_v3.0 Primary Assembly

General protein information

Preferred Names
1-phosphatidylinositol 3-phosphate 5-kinase

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UI_Ramb_v3.0 Primary Assembly

Genomic

  1. NC_056055.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Range
    210348243..210428809
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_042244112.1XP_042100046.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X1

    UniProtKB/TrEMBL
    W5QCJ0
    Conserved Domains (5) summary
    COG5253
    Location:15202109
    MSS4; Phosphatidylinositol-4-phosphate 5-kinase [Signal transduction mechanisms]
    cd03334
    Location:629889
    Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
    cd04448
    Location:369450
    DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
    cd15725
    Location:166227
    FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
    cd17300
    Location:18322098
    PIPKc_PIKfyve; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in 1-phosphatidylinositol-3-phosphate 5-kinase and similar proteins
  2. XM_042244119.1XP_042100053.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X7

    UniProtKB/TrEMBL
    W5QCJ0
    Conserved Domains (5) summary
    COG5253
    Location:15202054
    MSS4; Phosphatidylinositol-4-phosphate 5-kinase [Signal transduction mechanisms]
    cd03334
    Location:629889
    Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
    cd04448
    Location:369450
    DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
    cd15725
    Location:166227
    FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
    cd17300
    Location:17772043
    PIPKc_PIKfyve; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in 1-phosphatidylinositol-3-phosphate 5-kinase and similar proteins
  3. XM_042244117.1XP_042100051.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X3

    UniProtKB/TrEMBL
    W5QCJ0
    Conserved Domains (4) summary
    cd03334
    Location:629889
    Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
    cd04448
    Location:369450
    DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
    cd15725
    Location:166227
    FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
    cd17300
    Location:18302096
    PIPKc_PIKfyve; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in 1-phosphatidylinositol-3-phosphate 5-kinase and similar proteins
  4. XM_060410328.1XP_060266311.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X10

    UniProtKB/TrEMBL
    W5QCJ0
  5. XM_042244120.1XP_042100054.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X9

    UniProtKB/TrEMBL
    W5QCJ0
    Conserved Domains (5) summary
    COG5253
    Location:14642053
    MSS4; Phosphatidylinositol-4-phosphate 5-kinase [Signal transduction mechanisms]
    cd03334
    Location:573833
    Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
    cd04448
    Location:369450
    DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
    cd15725
    Location:166227
    FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
    cd17300
    Location:17762042
    PIPKc_PIKfyve; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in 1-phosphatidylinositol-3-phosphate 5-kinase and similar proteins
  6. XM_060410332.1XP_060266315.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X12

    UniProtKB/TrEMBL
    W5QCJ0
  7. XM_042244116.1XP_042100050.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X2

    UniProtKB/TrEMBL
    W5QCJ0
    Conserved Domains (5) summary
    COG5253
    Location:15192108
    MSS4; Phosphatidylinositol-4-phosphate 5-kinase [Signal transduction mechanisms]
    cd03334
    Location:628888
    Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
    cd04448
    Location:368449
    DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
    cd15725
    Location:165226
    FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
    cd17300
    Location:18312097
    PIPKc_PIKfyve; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in 1-phosphatidylinositol-3-phosphate 5-kinase and similar proteins
  8. XM_060410325.1XP_060266308.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X8

    UniProtKB/TrEMBL
    W5QCJ0
  9. XM_060410318.1XP_060266301.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X4

    UniProtKB/TrEMBL
    A0A6P7DS21, W5QCI9, W5QCJ0
  10. XM_060410334.1XP_060266317.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X13

    UniProtKB/TrEMBL
    W5QCJ0
  11. XM_060410330.1XP_060266313.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X11

    UniProtKB/TrEMBL
    W5QCJ0
  12. XM_042244121.1XP_042100055.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X14

    UniProtKB/TrEMBL
    W5QCJ0
    Conserved Domains (4) summary
    cd03334
    Location:572832
    Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
    cd04448
    Location:368449
    DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
    cd15725
    Location:165226
    FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
    cd17300
    Location:17732039
    PIPKc_PIKfyve; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in 1-phosphatidylinositol-3-phosphate 5-kinase and similar proteins
  13. XM_060410349.1XP_060266332.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X20

    UniProtKB/TrEMBL
    W5QCJ0
  14. XM_042244118.1XP_042100052.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X5

    UniProtKB/TrEMBL
    W5QCJ0
    Conserved Domains (5) summary
    COG5253
    Location:15082097
    MSS4; Phosphatidylinositol-4-phosphate 5-kinase [Signal transduction mechanisms]
    cd03334
    Location:617877
    Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
    cd04448
    Location:357438
    DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
    cd15725
    Location:154215
    FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
    cd17300
    Location:18202086
    PIPKc_PIKfyve; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in 1-phosphatidylinositol-3-phosphate 5-kinase and similar proteins
  15. XM_060410339.1XP_060266322.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X15

    UniProtKB/TrEMBL
    W5QCJ0
  16. XM_004004877.5XP_004004926.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X6

    See identical proteins and their annotated locations for XP_004004926.1

    UniProtKB/TrEMBL
    W5QCJ0
    Conserved Domains (4) summary
    cd00139
    Location:17722085
    PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
    cd03334
    Location:617877
    Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
    cd04448
    Location:357438
    DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
    cd15725
    Location:154215
    FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
  17. XM_060410342.1XP_060266325.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X17

    UniProtKB/TrEMBL
    W5QCJ0
  18. XM_060410340.1XP_060266323.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X16

    UniProtKB/TrEMBL
    W5QCJ0
  19. XM_060410345.1XP_060266328.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X18

    UniProtKB/TrEMBL
    W5QCJ0
  20. XM_060410353.1XP_060266336.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X22

    UniProtKB/TrEMBL
    W5QCJ0
  21. XM_042244113.1XP_042100047.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X1

    UniProtKB/TrEMBL
    W5QCJ0
    Conserved Domains (5) summary
    COG5253
    Location:15202109
    MSS4; Phosphatidylinositol-4-phosphate 5-kinase [Signal transduction mechanisms]
    cd03334
    Location:629889
    Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
    cd04448
    Location:369450
    DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
    cd15725
    Location:166227
    FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
    cd17300
    Location:18322098
    PIPKc_PIKfyve; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in 1-phosphatidylinositol-3-phosphate 5-kinase and similar proteins
  22. XM_060410336.1XP_060266319.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X13

    UniProtKB/TrEMBL
    W5QCJ0
  23. XM_060410331.1XP_060266314.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X11

    UniProtKB/TrEMBL
    W5QCJ0
  24. XM_060410322.1XP_060266305.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X5

    UniProtKB/TrEMBL
    W5QCJ0
  25. XM_060410324.1XP_060266307.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X6

    UniProtKB/TrEMBL
    W5QCJ0
  26. XM_060410344.1XP_060266327.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X17

    UniProtKB/TrEMBL
    W5QCJ0
  27. XM_042244114.1XP_042100048.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X1

    UniProtKB/TrEMBL
    W5QCJ0
    Conserved Domains (5) summary
    COG5253
    Location:15202109
    MSS4; Phosphatidylinositol-4-phosphate 5-kinase [Signal transduction mechanisms]
    cd03334
    Location:629889
    Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
    cd04448
    Location:369450
    DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
    cd15725
    Location:166227
    FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
    cd17300
    Location:18322098
    PIPKc_PIKfyve; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in 1-phosphatidylinositol-3-phosphate 5-kinase and similar proteins
  28. XM_060410315.1XP_060266298.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X3

    UniProtKB/TrEMBL
    W5QCJ0
    Related
    ENSOARP00020022037.1, ENSOART00020026550.2
  29. XM_060410327.1XP_060266310.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X10

    UniProtKB/TrEMBL
    W5QCJ0
    Related
    ENSOARP00020023444.2, ENSOART00020028290.2
  30. XM_060410326.1XP_060266309.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X9

    UniProtKB/TrEMBL
    W5QCJ0
  31. XM_060410333.1XP_060266316.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X12

    UniProtKB/TrEMBL
    W5QCJ0
    Related
    ENSOARP00020023770.2, ENSOART00020028678.2
  32. XM_060410348.1XP_060266331.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X19

    UniProtKB/TrEMBL
    W5QCJ0
  33. XM_060410313.1XP_060266296.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X2

    UniProtKB/TrEMBL
    W5QCJ0
  34. XM_060410317.1XP_060266300.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X4

    UniProtKB/TrEMBL
    A0A6P7DS21, W5QCI9, W5QCJ0
  35. XM_060410335.1XP_060266318.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X13

    UniProtKB/TrEMBL
    W5QCJ0
  36. XM_060410329.1XP_060266312.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X11

    UniProtKB/TrEMBL
    W5QCJ0
  37. XM_060410337.1XP_060266320.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X14

    UniProtKB/TrEMBL
    W5QCJ0
  38. XM_060410350.1XP_060266333.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X20

    UniProtKB/TrEMBL
    W5QCJ0
  39. XM_060410320.1XP_060266303.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X5

    UniProtKB/TrEMBL
    W5QCJ0
  40. XM_060410338.1XP_060266321.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X15

    UniProtKB/TrEMBL
    W5QCJ0
  41. XM_060410323.1XP_060266306.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X6

    UniProtKB/TrEMBL
    W5QCJ0
    Related
    ENSOARP00020022340.2, ENSOART00020026921.2
  42. XM_060410343.1XP_060266326.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X17

    UniProtKB/TrEMBL
    W5QCJ0
  43. XM_060410341.1XP_060266324.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X16

    UniProtKB/TrEMBL
    W5QCJ0
  44. XM_060410351.1XP_060266334.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X21

    UniProtKB/TrEMBL
    W5QCJ0
  45. XM_060410346.1XP_060266329.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X18

    UniProtKB/TrEMBL
    W5QCJ0
  46. XM_060410352.1XP_060266335.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X22

    UniProtKB/TrEMBL
    W5QCJ0
  47. XM_060410316.1XP_060266299.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X3

    UniProtKB/TrEMBL
    W5QCJ0
  48. XM_060410314.1XP_060266297.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X2

    UniProtKB/TrEMBL
    W5QCJ0
  49. XM_060410319.1XP_060266302.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X4

    UniProtKB/TrEMBL
    A0A6P7DS21, W5QCI9, W5QCJ0
  50. XM_060410354.1XP_060266337.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X23

    UniProtKB/TrEMBL
    W5QCJ0