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HMGCL 3-hydroxy-3-methylglutaryl-CoA lyase [ Ovis aries (sheep) ]

Gene ID: 101119699, updated on 11-Apr-2024

Summary

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Gene symbol
HMGCL
Gene description
3-hydroxy-3-methylglutaryl-CoA lyase
See related
EnsemblRapid:ENSOARG00020013128
Gene type
protein coding
RefSeq status
MODEL
Organism
Ovis aries
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 2 NC_056055.1 (242831761..242851036)

Chromosome 2 - NC_056055.1Genomic Context describing neighboring genes Neighboring gene cannabinoid receptor 2 Neighboring gene alpha-L-fucosidase 1 Neighboring gene UDP-galactose-4-epimerase Neighboring gene lysophospholipase 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_056055.1 Chromosome 2 Reference ARS-UI_Ramb_v3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables hydroxymethylglutaryl-CoA lyase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in L-leucine catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in ketone body biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
hydroxymethylglutaryl-CoA lyase, mitochondrial
Names
3-hydroxymethyl-3-methylglutaryl-CoA lyase

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UI_Ramb_v3.0 Primary Assembly

Genomic

  1. NC_056055.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Range
    242831761..242851036
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_004005125.4 → XP_004005174.3  hydroxymethylglutaryl-CoA lyase, mitochondrial

    UniProtKB/TrEMBL
    W5PAS5
    Related
    ENSOARP00020016623.2, ENSOART00020020077.2
    Conserved Domains (1) summary
    cl21457
    Location:17 → 325
    TIM; TIM-like beta/alpha barrel domains
Nucleotide Protein Strain
Heading Accession and Version

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