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PTEN phosphatase and tensin homolog [ Ovis aries (sheep) ]

Gene ID: 101119351, updated on 8-Mar-2024

Summary

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Gene symbol
PTEN
Gene description
phosphatase and tensin homolog
See related
EnsemblRapid:ENSOARG00020007451
Gene type
protein coding
RefSeq status
MODEL
Organism
Ovis aries
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
Orthologs
human mouse all
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Genomic context

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See PTEN in Genome Data Viewer
Location:
chromosome: 22
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 22 NC_056075.1 (9242035..9343998)

Chromosome 22 - NC_056075.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105604214 Neighboring gene killin, p53 regulated DNA replication inhibitor Neighboring gene uncharacterized LOC132658404 Neighboring gene renalase, FAD dependent amine oxidase Neighboring gene transfer RNA glycine (anticodon UCC)

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_056075.1 Chromosome 22 Reference ARS-UI_Ramb_v3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell motility IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol dephosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UI_Ramb_v3.0 Primary Assembly

Genomic

  1. NC_056075.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Range
    9242035..9343998
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_027960248.3 → XP_027816049.1  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X2

    UniProtKB/TrEMBL
    A0A6P7DDE8, W5PXK2
    Conserved Domains (2) summary
    cd14509
    Location:24 → 181
    PTP_PTEN; protein tyrosine phosphatase-like catalytic domain of phosphatase and tensin homolog
    pfam10409
    Location:188 → 349
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein

  2. XM_042238662.2 → XP_042094596.1  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1

    Related
    ENSOARP00020009317.2, ENSOART00020011352.2
    Conserved Domains (2) summary
    cd14509
    Location:24 → 166
    PTP_PTEN; protein tyrosine phosphatase-like catalytic domain of phosphatase and tensin homolog
    pfam10409
    Location:173 → 334
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
Nucleotide Protein Strain
Heading Accession and Version

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