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Tmem168 transmembrane protein 168 [ Mus musculus (house mouse) ]

Gene ID: 101118, updated on 2-Nov-2024

Summary

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Official Symbol
Tmem168provided by MGI
Official Full Name
transmembrane protein 168provided by MGI
Primary source
MGI:MGI:1921794
See related
Ensembl:ENSMUSG00000029569 AllianceGenome:MGI:1921794
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5730526F17Rik; 8430437G11Rik
Summary
Predicted to enable sodium channel regulator activity. Acts upstream of or within regulation of ubiquitin-dependent protein catabolic process and regulation of voltage-gated sodium channel activity. Located in nuclear membrane. Is expressed in cerebral cortex ventricular layer and heart ventricle. Orthologous to human TMEM168 (transmembrane protein 168). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in placenta adult (RPKM 7.0), bladder adult (RPKM 6.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tmem168 in Genome Data Viewer
Location:
6 A1; 6 5.68 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (13580688..13608097, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (13580689..13608098, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein S10 pseudogene Neighboring gene STARR-seq mESC enhancer starr_15194 Neighboring gene predicted gene, 25737 Neighboring gene STARR-seq mESC enhancer starr_15196 Neighboring gene STARR-positive B cell enhancer ABC_E10370 Neighboring gene STARR-seq mESC enhancer starr_15197 Neighboring gene base methyltransferase of 25S rRNA 2 Neighboring gene STARR-positive B cell enhancer ABC_E2186 Neighboring gene predicted gene, 53312

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of transmembrane protein 168 mutation in familial Brugada syndrome. Shimizu A, et al. FASEB J, 2020 May. PMID 32175648
  2. Transmembrane protein 168 mutation reduces cardiomyocyte cell surface expression of Nav1.5 through αB-crystallin intracellular dynamics. Nguyen LKC, et al. J Biochem, 2021 Dec 28. PMID 34086898
  3. The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. Sansom SN, et al. PLoS Genet, 2009 Jun. PMID 19521500, Free PMC Article
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Transmembrane protein 168 mutation reduces cardiomyocyte cell surface expression of Nav1.5 through alphaB-crystallin intracellular dynamics.
    Title: Transmembrane protein 168 mutation reduces cardiomyocyte cell surface expression of Nav1.5 through αB-crystallin intracellular dynamics.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1)  1 citation
  • Gene trapped (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables sodium channel regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables sodium channel regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within regulation of ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of voltage-gated sodium channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in transport vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in transport vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transmembrane protein 168

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028990.5 → NP_083266.1  transmembrane protein 168

    See identical proteins and their annotated locations for NP_083266.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer, protein-coding transcript.
    Source sequence(s)
    AC139884, AK051532
    Consensus CDS
    CCDS19915.1
    UniProtKB/Swiss-Prot
    Q3TDA5, Q91VX9
    Related
    ENSMUSP00000031554.3, ENSMUST00000031554.9

RNA

  1. NR_155435.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AC139884
    Related
    ENSMUST00000149123.3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    13580688..13608097 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504953.5 → XP_006505016.1  transmembrane protein 168 isoform X1

    See identical proteins and their annotated locations for XP_006505016.1

    UniProtKB/Swiss-Prot
    Q3TDA5, Q91VX9

  2. XM_006504952.5 → XP_006505015.1  transmembrane protein 168 isoform X1

    See identical proteins and their annotated locations for XP_006505015.1

    UniProtKB/Swiss-Prot
    Q3TDA5, Q91VX9

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001347059.1: Suppressed sequence

    Description
    NM_001347059.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91VX9.1 GenPept UniProtKB/Swiss-Prot:Q91VX9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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