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ALOX5 arachidonate 5-lipoxygenase [ Ovis aries (sheep) ]

Gene ID: 101117390, updated on 8-Mar-2024

Summary

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Gene symbol
ALOX5
Gene description
arachidonate 5-lipoxygenase
See related
EnsemblRapid:ENSOARG00020023385
Gene type
protein coding
RefSeq status
MODEL
Organism
Ovis aries
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
Orthologs
human mouse all
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Genomic context

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See ALOX5 in Genome Data Viewer
Location:
chromosome: 25
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 25 NC_056078.1 (43313506..43360884, complement)

Chromosome 25 - NC_056078.1Genomic Context describing neighboring genes Neighboring gene zinc finger AN1-type containing 4 Neighboring gene membrane associated ring-CH-type finger 8 Neighboring gene olfactory receptor 13A1 Neighboring gene olfactory receptor 6C2-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_056078.1 Chromosome 25 Reference ARS-UI_Ramb_v3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables arachidonate 5-lipoxygenase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in linoleic acid metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in lipid oxidation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nuclear envelope IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
polyunsaturated fatty acid 5-lipoxygenase

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UI_Ramb_v3.0 Primary Assembly

Genomic

  1. NC_056078.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Range
    43313506..43360884 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015104505.4 → XP_014959991.2  polyunsaturated fatty acid 5-lipoxygenase isoform X2

    UniProtKB/TrEMBL
    W5NXV2
    Related
    ENSOARP00020054139.1, ENSOART00020036437.2

  2. XM_027962219.3 → XP_027818020.1  polyunsaturated fatty acid 5-lipoxygenase isoform X1

    UniProtKB/TrEMBL
    A0A6P7DGY1, W5NXV2
    Related
    ENSOARP00020058626.1, ENSOART00020036410.2
    Conserved Domains (2) summary
    cd01753
    Location:2 → 115
    PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
    pfam00305
    Location:227 → 665
    Lipoxygenase
Nucleotide Protein Strain
Heading Accession and Version

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