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ALOX12 arachidonate 12-lipoxygenase, 12S type [ Ovis aries (sheep) ]

Gene ID: 101113685, updated on 10-Oct-2024

Summary

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Gene symbol
ALOX12
Gene description
arachidonate 12-lipoxygenase, 12S type
See related
EnsemblRapid:ENSOARG00020021553
Gene type
protein coding
RefSeq status
MODEL
Organism
Ovis aries
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
Orthologs
human mouse all
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Genomic context

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See ALOX12 in Genome Data Viewer
Location:
chromosome: 11
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 11 NC_056064.1 (26672877..26686502)

Chromosome 11 - NC_056064.1Genomic Context describing neighboring genes Neighboring gene DNA-directed RNA polymerase III subunit RPC6-like Neighboring gene polyunsaturated fatty acid (12S)/(13S)-lipoxygenase, epidermal-type-like Neighboring gene transcription initiation factor TFIID subunit 13-like Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC132657407 Neighboring gene ribonuclease K Neighboring gene BPTF associated chromatin complex component 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_056064.1 Chromosome 11 Reference ARS-UI_Ramb_v3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables arachidonate 12(S)-lipoxygenase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables arachidonate 15-lipoxygenase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables linoleate 13S-lipoxygenase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in linoleic acid metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in lipid oxidation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in sarcolemma IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
polyunsaturated fatty acid lipoxygenase ALOX12

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UI_Ramb_v3.0 Primary Assembly

Genomic

  1. NC_056064.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Range
    26672877..26686502
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015098595.4 → XP_014954081.2  polyunsaturated fatty acid lipoxygenase ALOX12 isoform X3

    UniProtKB/TrEMBL
    A0A6P3YJY3, A0A8X8M481, W5PHM1
    Related
    ENSOARP00020027519.1, ENSOART00020033303.2
    Conserved Domains (2) summary
    cd01753
    Location:2 → 111
    PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
    pfam00305
    Location:217 → 654
    Lipoxygenase

  2. XM_060395376.1 → XP_060251359.1  polyunsaturated fatty acid lipoxygenase ALOX12 isoform X4

    UniProtKB/TrEMBL
    A0A8X8M411

  3. XM_027975054.3 → XP_027830855.2  polyunsaturated fatty acid lipoxygenase ALOX12 isoform X1

    UniProtKB/TrEMBL
    W5PHM1
    Related
    ENSOARP00020052035.1, ENSOART00020054995.1
    Conserved Domains (2) summary
    PLN02305
    Location:265 → 706
    PLN02305; lipoxygenase
    cl00011
    Location:87 → 154
    PLAT; PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and ...

  4. XM_027975056.3 → XP_027830857.2  polyunsaturated fatty acid lipoxygenase ALOX12 isoform X2

    UniProtKB/TrEMBL
    W5PHM1
    Conserved Domains (2) summary
    PLN02305
    Location:265 → 662
    PLN02305; lipoxygenase
    cl00011
    Location:87 → 154
    PLAT; PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and ...

  5. XM_060395377.1 → XP_060251360.1  polyunsaturated fatty acid lipoxygenase ALOX12 isoform X5

  6. XM_027975057.3 → XP_027830858.2  polyunsaturated fatty acid lipoxygenase ALOX12 isoform X6

    Conserved Domains (2) summary
    PLN02305
    Location:265 → 590
    PLN02305; lipoxygenase
    cl00011
    Location:87 → 154
    PLAT; PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and ...
Nucleotide Protein Strain
Heading Accession and Version

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