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WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 [ Ovis aries (sheep) ]

Gene ID: 101104075, updated on 8-Mar-2024

Summary

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Gene symbol
WFIKKN2
Gene description
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
See related
EnsemblRapid:ENSOARG00020026152
Gene type
protein coding
RefSeq status
MODEL
Organism
Ovis aries
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
Orthologs
human mouse all
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Genomic context

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See WFIKKN2 in Genome Data Viewer
Location:
chromosome: 11
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 11 NC_056064.1 (35646021..35652527, complement)

Chromosome 11 - NC_056064.1Genomic Context describing neighboring genes Neighboring gene group XIIA secretory phospholipase A2-like Neighboring gene transducer of ERBB2, 1 Neighboring gene ANKRD40 C-terminal like Neighboring gene LUC7 like 3 pre-mRNA splicing factor

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_056064.1 Chromosome 11 Reference ARS-UI_Ramb_v3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Variation in the ovine WFIKKN2 gene. Wang J, et al. Gene, 2014 Jun 10. PMID 24704001
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables receptor antagonist activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transforming growth factor beta binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UI_Ramb_v3.0 Primary Assembly

Genomic

  1. NC_056064.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Range
    35646021..35652527 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_060395533.1 → XP_060251516.1  WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 isoform X2

  2. XM_004012757.6 → XP_004012806.1  WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_004012806.1

    UniProtKB/TrEMBL
    A0A6P3E808, W5NZ88
    Related
    ENSOARP00020034152.2, ENSOART00020041140.2
    Conserved Domains (6) summary
    cd05765
    Location:222 → 302
    Ig_3; Subgroup of the immunoglobulin (Ig) superfamily
    cd00104
    Location:136 → 172
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd03575
    Location:453 → 561
    NTR_WFIKKN; NTR domain, WFIKKN subfamily; WFIKKN proteins contain a C-terminal NTR domain and are putative secreted proteins which may be multivalent protease inhibitors that act on serine proteases as well as metalloproteases. Human WFIKKN and a related protein ...
    pfam07679
    Location:208 → 302
    I-set; Immunoglobulin I-set domain
    pfam00014
    Location:383 → 434
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam00095
    Location:42 → 88
    WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'

  3. XM_027974739.3 → XP_027830540.1  WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 isoform X2

    Conserved Domains (4) summary
    cd00104
    Location:45 → 81
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd03575
    Location:362 → 470
    NTR_WFIKKN; NTR domain, WFIKKN subfamily; WFIKKN proteins contain a C-terminal NTR domain and are putative secreted proteins which may be multivalent protease inhibitors that act on serine proteases as well as metalloproteases. Human WFIKKN and a related protein ...
    pfam00014
    Location:292 → 343
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    cd05765
    Location:117 → 211
    IgI_3_WFIKKN-like; Third immunoglobulin-like domain of the human WFIKKN (WAP, follistatin, immunoglobulin, Kunitz and NTR domain-containing protein), and similar domains; member of the I-set of Ig superfamily (IgSF) domains
Nucleotide Protein Strain
Heading Accession and Version

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