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CBLB Cbl proto-oncogene B [ Felis catus (domestic cat) ]

Gene ID: 101101498, updated on 17-Aug-2024

Summary

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Official Symbol
CBLB
Official Full Name
Cbl proto-oncogene B
Primary source
VGNC:VGNC:60421
See related
EnsemblRapid:ENSFCTG00005009558
Gene type
protein coding
RefSeq status
MODEL
Organism
Felis catus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis
Orthologs
human mouse all
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Genomic context

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See CBLB in Genome Data Viewer
Location:
chromosome: C2
Exon count:
22
Annotation release Status Assembly Chr Location
105 current F.catus_Fca126_mat1.0 (GCF_018350175.1) C2 NC_058376.1 (52737127..52960889, complement)
104 previous assembly Felis_catus_9.0 (GCF_000181335.3) C2 NC_018731.3 (52955259..53179953, complement)

Chromosome C2 - NC_058376.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC109503420 Neighboring gene activated leukocyte cell adhesion molecule Neighboring gene uncharacterized LOC123379938 Neighboring gene uncharacterized LOC109491700

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphotyrosine residue binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables receptor tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of epidermal growth factor-activated receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase CBL-B
Names
Cbl proto-oncogene, E3 ubiquitin protein ligase B

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Felis catus Annotation Release 105 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference F.catus_Fca126_mat1.0 Primary Assembly

Genomic

  1. NC_058376.1 Reference F.catus_Fca126_mat1.0 Primary Assembly

    Range
    52737127..52960889 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006936020.5 → XP_006936082.1  E3 ubiquitin-protein ligase CBL-B isoform X1

    See identical proteins and their annotated locations for XP_006936082.1

    UniProtKB/TrEMBL
    A0A2I2UBH4, M3W2E6
    Related
    ENSFCTP00005017580.1, ENSFCTT00005027098.1
    Conserved Domains (5) summary
    cd09920
    Location:248 → 344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd14392
    Location:933 → 973
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    cd16709
    Location:354 → 419
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44 → 164
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:171 → 254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

  2. XM_006936021.5 → XP_006936083.1  E3 ubiquitin-protein ligase CBL-B isoform X3

    UniProtKB/TrEMBL
    A0A2I2UBH4
    Related
    ENSFCTP00005017496.1, ENSFCTT00005026990.1
    Conserved Domains (5) summary
    cd09920
    Location:248 → 344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd14392
    Location:889 → 929
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    cd16709
    Location:354 → 419
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44 → 164
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:171 → 254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

  3. XM_019839645.3 → XP_019695204.1  E3 ubiquitin-protein ligase CBL-B isoform X2

    UniProtKB/TrEMBL
    A0A2I2UBH4, A0A337SBX7
    Related
    ENSFCTP00005017465.1, ENSFCTT00005026943.1
    Conserved Domains (5) summary
    cd09920
    Location:248 → 344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd14392
    Location:893 → 933
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    cd16709
    Location:354 → 419
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44 → 164
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:171 → 254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

  4. XM_006936019.5 → XP_006936081.1  E3 ubiquitin-protein ligase CBL-B isoform X1

    See identical proteins and their annotated locations for XP_006936081.1

    UniProtKB/TrEMBL
    A0A2I2UBH4, M3W2E6
    Related
    ENSFCTP00005017371.1, ENSFCTT00005026799.1
    Conserved Domains (5) summary
    cd09920
    Location:248 → 344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd14392
    Location:933 → 973
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    cd16709
    Location:354 → 419
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44 → 164
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:171 → 254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

  5. XM_045036885.1 → XP_044892820.1  E3 ubiquitin-protein ligase CBL-B isoform X1

    UniProtKB/TrEMBL
    A0A2I2UBH4, M3W2E6
    Conserved Domains (5) summary
    cd09920
    Location:248 → 344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd14392
    Location:933 → 973
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    cd16709
    Location:354 → 419
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:44 → 164
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:171 → 254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
Nucleotide Protein
Heading Accession and Version

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