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AGRN agrin [ Felis catus (domestic cat) ]

Gene ID: 101101121, updated on 17-Aug-2024

Summary

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Official Symbol
AGRN
Official Full Name
agrin
Primary source
VGNC:VGNC:82427
See related
EnsemblRapid:ENSFCTG00005015870
Gene type
protein coding
RefSeq status
MODEL
Organism
Felis catus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis
Orthologs
human mouse all
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Genomic context

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See AGRN in Genome Data Viewer
Location:
chromosome: C1
Exon count:
40
Annotation release Status Assembly Chr Location
105 current F.catus_Fca126_mat1.0 (GCF_018350175.1) C1 NC_058375.1 (142072..176739)
104 previous assembly Felis_catus_9.0 (GCF_000181335.3) C1 NC_018730.3 (139444..174062)

Chromosome C1 - NC_058375.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111561656 Neighboring gene ISG15 ubiquitin like modifier Neighboring gene uncharacterized LOC123379434 Neighboring gene tyrosine-protein phosphatase non-receptor type 11-like Neighboring gene RING finger protein 223

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables laminin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled acetylcholine receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in receptor clustering IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
agrin

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Felis catus Annotation Release 105 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference F.catus_Fca126_mat1.0 Primary Assembly

Genomic

  1. NC_058375.1 Reference F.catus_Fca126_mat1.0 Primary Assembly

    Range
    142072..176739
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_023257882.2 → XP_023113650.1  agrin isoform X1

    UniProtKB/TrEMBL
    A0A5F5XNB8
    Conserved Domains (9) summary
    smart00280
    Location:491 → 536
    KAZAL; Kazal type serine protease inhibitors
    smart00200
    Location:1137 → 1261
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    cd00054
    Location:1797 → 1829
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00104
    Location:423 → 463
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd00110
    Location:1385 → 1534
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00053
    Location:795 → 837
    Laminin_EGF; Laminin EGF domain
    pfam00054
    Location:1893 → 2023
    Laminin_G_1; Laminin G domain
    pfam00008
    Location:1341 → 1373
    EGF; EGF-like domain
    pfam03146
    Location:46 → 148
    NtA; Agrin NtA domain

  2. XM_023257885.2 → XP_023113653.1  agrin isoform X4

    UniProtKB/TrEMBL
    A0A5F5XNB8
    Conserved Domains (9) summary
    smart00280
    Location:491 → 536
    KAZAL; Kazal type serine protease inhibitors
    smart00200
    Location:1137 → 1261
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    cd00054
    Location:1797 → 1829
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00104
    Location:423 → 463
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd00110
    Location:1385 → 1534
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00053
    Location:795 → 837
    Laminin_EGF; Laminin EGF domain
    pfam00054
    Location:1874 → 2004
    Laminin_G_1; Laminin G domain
    pfam00008
    Location:1341 → 1373
    EGF; EGF-like domain
    pfam03146
    Location:46 → 148
    NtA; Agrin NtA domain

  3. XM_023257883.2 → XP_023113651.1  agrin isoform X2

    UniProtKB/TrEMBL
    A0A5F5XNB8
    Conserved Domains (9) summary
    smart00280
    Location:491 → 536
    KAZAL; Kazal type serine protease inhibitors
    smart00200
    Location:1137 → 1261
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    cd00054
    Location:1793 → 1825
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00104
    Location:423 → 463
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd00110
    Location:1385 → 1534
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00053
    Location:795 → 837
    Laminin_EGF; Laminin EGF domain
    pfam00054
    Location:1889 → 2019
    Laminin_G_1; Laminin G domain
    pfam00008
    Location:1341 → 1373
    EGF; EGF-like domain
    pfam03146
    Location:46 → 148
    NtA; Agrin NtA domain

  4. XM_023257884.2 → XP_023113652.1  agrin isoform X3

    UniProtKB/TrEMBL
    A0A5F5XNB8
    Conserved Domains (9) summary
    smart00280
    Location:491 → 536
    KAZAL; Kazal type serine protease inhibitors
    smart00200
    Location:1131 → 1255
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    cd00054
    Location:1791 → 1823
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00104
    Location:423 → 463
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd00110
    Location:1379 → 1528
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00053
    Location:795 → 837
    Laminin_EGF; Laminin EGF domain
    pfam00054
    Location:1887 → 2017
    Laminin_G_1; Laminin G domain
    pfam00008
    Location:1335 → 1367
    EGF; EGF-like domain
    pfam03146
    Location:46 → 148
    NtA; Agrin NtA domain

  5. XM_023257886.2 → XP_023113654.1  agrin isoform X5

    UniProtKB/TrEMBL
    A0A5F5XNB8
    Conserved Domains (9) summary
    smart00280
    Location:491 → 536
    KAZAL; Kazal type serine protease inhibitors
    smart00200
    Location:1137 → 1261
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    cd00054
    Location:1793 → 1825
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00104
    Location:423 → 463
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd00110
    Location:1385 → 1534
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00053
    Location:795 → 837
    Laminin_EGF; Laminin EGF domain
    pfam00054
    Location:1870 → 2000
    Laminin_G_1; Laminin G domain
    pfam00008
    Location:1341 → 1373
    EGF; EGF-like domain
    pfam03146
    Location:46 → 148
    NtA; Agrin NtA domain

  6. XM_023257888.2 → XP_023113656.1  agrin isoform X8

    UniProtKB/TrEMBL
    A0A5F5XNB8
    Conserved Domains (9) summary
    smart00280
    Location:491 → 536
    KAZAL; Kazal type serine protease inhibitors
    smart00200
    Location:1131 → 1255
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    cd00054
    Location:1787 → 1819
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00104
    Location:423 → 463
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd00110
    Location:1379 → 1528
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00053
    Location:795 → 837
    Laminin_EGF; Laminin EGF domain
    pfam00054
    Location:1864 → 1994
    Laminin_G_1; Laminin G domain
    pfam00008
    Location:1335 → 1367
    EGF; EGF-like domain
    pfam03146
    Location:46 → 148
    NtA; Agrin NtA domain

  7. XM_019835969.3 → XP_019691528.2  agrin isoform X6

    UniProtKB/TrEMBL
    A0A5F5XNB8
    Conserved Domains (8) summary
    smart00280
    Location:384 → 429
    KAZAL; Kazal type serine protease inhibitors
    smart00200
    Location:1030 → 1154
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    cd00054
    Location:1690 → 1722
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00104
    Location:316 → 356
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd00110
    Location:1278 → 1427
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00053
    Location:688 → 730
    Laminin_EGF; Laminin EGF domain
    pfam00054
    Location:1786 → 1916
    Laminin_G_1; Laminin G domain
    pfam00008
    Location:1234 → 1266
    EGF; EGF-like domain

  8. XM_019835970.3 → XP_019691529.2  agrin isoform X7

    UniProtKB/TrEMBL
    A0A5F5XNB8
    Related
    ENSFCTP00005032365.1, ENSFCTT00005045315.1
    Conserved Domains (8) summary
    smart00280
    Location:384 → 429
    KAZAL; Kazal type serine protease inhibitors
    smart00200
    Location:1024 → 1148
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    cd00054
    Location:1684 → 1716
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00104
    Location:316 → 356
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd00110
    Location:1272 → 1421
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00053
    Location:688 → 730
    Laminin_EGF; Laminin EGF domain
    pfam00054
    Location:1780 → 1910
    Laminin_G_1; Laminin G domain
    pfam00008
    Location:1228 → 1260
    EGF; EGF-like domain

  9. XM_019835971.3 → XP_019691530.2  agrin isoform X9

    UniProtKB/TrEMBL
    A0A5F5XNB8
    Related
    ENSFCTP00005032683.1, ENSFCTT00005045719.1
    Conserved Domains (8) summary
    smart00280
    Location:384 → 429
    KAZAL; Kazal type serine protease inhibitors
    smart00200
    Location:1024 → 1148
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    cd00054
    Location:1684 → 1716
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00104
    Location:316 → 356
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    cd00110
    Location:1272 → 1421
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00053
    Location:688 → 730
    Laminin_EGF; Laminin EGF domain
    pfam00054
    Location:1761 → 1891
    Laminin_G_1; Laminin G domain
    pfam00008
    Location:1228 → 1260
    EGF; EGF-like domain
Nucleotide Protein
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