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PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [ Felis catus (domestic cat) ]

Gene ID: 101091892, updated on 17-Aug-2024

Summary

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Official Symbol
PIK3CB
Official Full Name
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
Primary source
VGNC:VGNC:68855
See related
EnsemblRapid:ENSFCTG00005015840
Gene type
protein coding
RefSeq status
MODEL
Organism
Felis catus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis
Orthologs
human mouse all
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Genomic context

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See PIK3CB in Genome Data Viewer
Location:
chromosome: C2
Exon count:
26
Annotation release Status Assembly Chr Location
105 current F.catus_Fca126_mat1.0 (GCF_018350175.1) C2 NC_058376.1 (124208422..124394487)
104 previous assembly Felis_catus_9.0 (GCF_000181335.3) C2 NC_018731.3 (126760839..126948866)

Chromosome C2 - NC_058376.1Genomic Context describing neighboring genes Neighboring gene chloride intracellular channel protein 1-like Neighboring gene small ubiquitin-related modifier 2-like Neighboring gene small nucleolar RNA U13 Neighboring gene U6 spliceosomal RNA Neighboring gene Fas apoptotic inhibitory molecule Neighboring gene centrosomal protein 70 Neighboring gene uncharacterized LOC123380117 Neighboring gene extended synaptotagmin 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol-3-phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of phosphatidylinositol 3-kinase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Felis catus Annotation Release 105 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference F.catus_Fca126_mat1.0 Primary Assembly

Genomic

  1. NC_058376.1 Reference F.catus_Fca126_mat1.0 Primary Assembly

    Range
    124208422..124394487
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011286143.4 → XP_011284445.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

    UniProtKB/TrEMBL
    A0A2I2U4I1, M3VZ77
    Related
    ENSFCTP00005032482.1, ENSFCTT00005045462.1
    Conserved Domains (5) summary
    cd08693
    Location:324 → 501
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00143
    Location:41 → 118
    PI3K_p85B; PI3-kinase family, p85-binding domain
    smart00144
    Location:180 → 288
    PI3K_rbd; PI3-kinase family, Ras-binding domain
    cd00872
    Location:532 → 702
    PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
    cd05173
    Location:706 → 1067
    PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta

  2. XM_045037520.1 → XP_044893455.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

    UniProtKB/TrEMBL
    A0A2I2U4I1, M3VZ77
    Conserved Domains (5) summary
    cd08693
    Location:324 → 501
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00143
    Location:41 → 118
    PI3K_p85B; PI3-kinase family, p85-binding domain
    smart00144
    Location:180 → 288
    PI3K_rbd; PI3-kinase family, Ras-binding domain
    cd00872
    Location:532 → 702
    PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
    cd05173
    Location:706 → 1067
    PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta

  3. XM_045037521.1 → XP_044893456.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

    UniProtKB/TrEMBL
    A0A2I2U4I1, M3VZ77
    Conserved Domains (5) summary
    cd08693
    Location:324 → 501
    C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
    smart00143
    Location:41 → 118
    PI3K_p85B; PI3-kinase family, p85-binding domain
    smart00144
    Location:180 → 288
    PI3K_rbd; PI3-kinase family, Ras-binding domain
    cd00872
    Location:532 → 702
    PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
    cd05173
    Location:706 → 1067
    PI3Kc_IA_beta; Catalytic domain of Class IA Phosphoinositide 3-kinase beta
Nucleotide Protein
Heading Accession and Version

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