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CAPN3 calpain 3 [ Felis catus (domestic cat) ]

Gene ID: 101081304, updated on 17-Aug-2024

Summary

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Official Symbol
CAPN3
Official Full Name
calpain 3
Primary source
VGNC:VGNC:81025
See related
EnsemblRapid:ENSFCTG00005016936
Gene type
protein coding
RefSeq status
MODEL
Organism
Felis catus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis
Orthologs
human mouse all
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Genomic context

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See CAPN3 in Genome Data Viewer
Location:
chromosome: B3
Exon count:
25
Annotation release Status Assembly Chr Location
105 current F.catus_Fca126_mat1.0 (GCF_018350175.1) B3 NC_058373.1 (60741552..60791496, complement)
104 previous assembly Felis_catus_9.0 (GCF_000181335.3) B3 NC_018728.3 (62974874..63024668, complement)

Chromosome B3 - NC_058373.1Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 57 Neighboring gene synaptosome associated protein 23 Neighboring gene ferritin light chain-like Neighboring gene zinc finger protein 106 Neighboring gene uncharacterized LOC123385971 Neighboring gene glucosidase alpha, neutral C Neighboring gene U2 spliceosomal RNA Neighboring gene U6 spliceosomal RNA Neighboring gene transmembrane protein 87A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium-dependent cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
calpain-3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Felis catus Annotation Release 105 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference F.catus_Fca126_mat1.0 Primary Assembly

Genomic

  1. NC_058373.1 Reference F.catus_Fca126_mat1.0 Primary Assembly

    Range
    60741552..60791496 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_019832622.3 → XP_019688181.2  calpain-3 isoform X4

    UniProtKB/TrEMBL
    A0A337SAD9
    Related
    ENSFCTP00005036206.1, ENSFCTT00005049775.1
    Conserved Domains (3) summary
    pfam00648
    Location:77 → 415
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:436 → 579
    Calpain_III; Calpain large subunit, domain III
    cd16190
    Location:609 → 777
    EFh_PEF_CAPN3; Calcium-activated neutral

  2. XM_045059489.1 → XP_044915424.1  calpain-3 isoform X3

    UniProtKB/TrEMBL
    A0A337SAD9
    Conserved Domains (3) summary
    smart00230
    Location:61 → 425
    CysPc; Calpain-like thiol protease family
    cd00214
    Location:427 → 584
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    cd16190
    Location:615 → 783
    EFh_PEF_CAPN3; Calcium-activated neutral

  3. XM_003987244.6 → XP_003987293.4  calpain-3 isoform X1

    UniProtKB/TrEMBL
    A0A337SAD9, A0A337SDY1
    Related
    ENSFCTP00005035592.1, ENSFCTT00005049100.1
    Conserved Domains (4) summary
    pfam00648
    Location:77 → 415
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:436 → 579
    Calpain_III; Calpain large subunit, domain III
    pfam16648
    Location:583 → 653
    Calpain_u2; Unstructured region on Calpain-3
    cd16190
    Location:653 → 821
    EFh_PEF_CAPN3; Calcium-activated neutral

  4. XM_019832623.3 → XP_019688182.1  calpain-3 isoform X5

    UniProtKB/TrEMBL
    A0A337SAD9
    Related
    ENSFCTP00005035314.1, ENSFCTT00005048785.1
    Conserved Domains (3) summary
    pfam00648
    Location:51 → 395
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:416 → 559
    Calpain_III; Calpain large subunit, domain III
    cd16190
    Location:589 → 757
    EFh_PEF_CAPN3; Calcium-activated neutral

  5. XM_019832621.3 → XP_019688180.1  calpain-3 isoform X2

    UniProtKB/TrEMBL
    A0A337SAD9
    Conserved Domains (4) summary
    pfam00648
    Location:51 → 395
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:416 → 559
    Calpain_III; Calpain large subunit, domain III
    pfam16648
    Location:563 → 633
    Calpain_u2; Unstructured region on Calpain-3
    cd16190
    Location:633 → 801
    EFh_PEF_CAPN3; Calcium-activated neutral
Nucleotide Protein
Heading Accession and Version

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