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TSPAN1 tetraspanin 1 [ Homo sapiens (human) ]

Gene ID: 10103, updated on 11-Apr-2024

Summary

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Official Symbol
TSPAN1provided by HGNC
Official Full Name
tetraspanin 1provided by HGNC
Primary source
HGNC:HGNC:20657
See related
Ensembl:ENSG00000117472 MIM:613170; AllianceGenome:HGNC:20657
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NET1; TM4C; TM4SF
Summary
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. [provided by RefSeq, Jul 2008]
Expression
Biased expression in colon (RPKM 237.8), prostate (RPKM 118.0) and 10 other tissues See more
Orthologs
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Genomic context

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Location:
1p34.1
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (46175087..46196489)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (46052282..46073710)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (46640759..46651634)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene P3R3URF-PIK3R3 readthrough Neighboring gene phosphoinositide-3-kinase regulatory subunit 3 Neighboring gene COX7B pseudogene 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 991 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 992 Neighboring gene uncharacterized LOC101929626 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 993 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 994 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 995 Neighboring gene PIK3R3 upstream open reading frame Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 837 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 838 Neighboring gene protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:46683827-46684328 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:46685102-46685602 Neighboring gene leucine rich adaptor protein 1 Neighboring gene MPRA-validated peak204 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 839 Neighboring gene RAD54 like Neighboring gene leucine rich repeat containing 41

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The immunological characteristics of TSPAN1 expressing B cells in autoimmune hepatitis. Ou Y, et al. Front Immunol, 2022. PMID 36591302, Free PMC Article
  2. Tetraspanin 1 (TSPAN1) promotes growth and transferation of breast cancer cells via mediating PI3K/Akt pathway. Wu Y, et al. Bioengineered, 2021 Dec. PMID 34852709, Free PMC Article
  3. Tetraspanin 1 promotes endometriosis leading to ovarian clear cell carcinoma. Shin HY, et al. Mol Oncol, 2021 Apr. PMID 33331115, Free PMC Article
  4. Bioinformatics analysis reveals TSPAN1 as a candidate biomarker of progression and prognosis in pancreatic cancer. Ma C, et al. Bosn J Basic Med Sci, 2021 Feb 1. PMID 33188589, Free PMC Article
  5. Tetraspanin 1 promotes epithelial-to-mesenchymal transition and metastasis of cholangiocarcinoma via PI3K/AKT signaling. Wang Y, et al. J Exp Clin Cancer Res, 2018 Dec 4. PMID 30514341, Free PMC Article

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TSPAN1 inhibits metastasis of nasopharyngeal carcinoma via suppressing NF-kB signaling.
    Title: TSPAN1 inhibits metastasis of nasopharyngeal carcinoma via suppressing NF-kB signaling.
  2. ALKBH5 Suppresses Autophagy in Prostate Cancer Cells via Inhibiting m6A-Modification of TSPAN1 mRNA.
    Title: ALKBH5 Suppresses Autophagy in Prostate Cancer Cells via Inhibiting m6A-Modification of TSPAN1 mRNA.
  3. The immunological characteristics of TSPAN1 expressing B cells in autoimmune hepatitis.
    Title: The immunological characteristics of TSPAN1 expressing B cells in autoimmune hepatitis.
  4. TSPAN1 promotes autophagy flux and mediates cooperation between WNT-CTNNB1 signaling and autophagy via the MIR454-FAM83A-TSPAN1 axis in pancreatic cancer.
    Title: TSPAN1 promotes autophagy flux and mediates cooperation between WNT-CTNNB1 signaling and autophagy via the MIR454-FAM83A-TSPAN1 axis in pancreatic cancer.
  5. Tetraspanin 1 (TSPAN1) promotes growth and transferation of breast cancer cells via mediating PI3K/Akt pathway.
    Title: Tetraspanin 1 (TSPAN1) promotes growth and transferation of breast cancer cells via mediating PI3K/Akt pathway.
  6. Tetraspanin 1 promotes endometriosis leading to ovarian clear cell carcinoma.
    Title: Tetraspanin 1 promotes endometriosis leading to ovarian clear cell carcinoma.
  7. Bioinformatics analysis reveals TSPAN1 as a candidate biomarker of progression and prognosis in pancreatic cancer.
    Title: Bioinformatics analysis reveals TSPAN1 as a candidate biomarker of progression and prognosis in pancreatic cancer.
  8. miR-573 suppresses pancreatic cancer cell proliferation, migration, and invasion through targeting TSPAN1.
    Title: miR-573 suppresses pancreatic cancer cell proliferation, migration, and invasion through targeting TSPAN1.
  9. Prognostic role of TSPAN1, KIAA1324 and ESRP1 in prostate cancer.
    Title: Prognostic role of TSPAN1, KIAA1324 and ESRP1 in prostate cancer.
  10. Silencing tetraspanin 1 (TSPAN1) promotes the phosphorylation of Smad2 protein (Smad2)/Smad3 protein (Smad3) and stabilizes beta-catenin protein.
    Title: Tetraspanin 1 as a mediator of fibrosis inhibits EMT process and Smad2/3 and beta-catenin pathway in human pulmonary fibrosis.
Submit: New GeneRIF Correction See all GeneRIFs (33)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein stabilization IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cell junction IDA
Inferred from Direct Assay
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular exosome HDA PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in vesicle HDA PubMed 
located_in vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
tetraspanin-1
Names
tetraspan 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005727.4 → NP_005718.2  tetraspanin-1

    See identical proteins and their annotated locations for NP_005718.2

    Status: REVIEWED

    Source sequence(s)
    AF065388, AK313774, BM856468
    Consensus CDS
    CCDS530.1
    UniProtKB/Swiss-Prot
    D3DQ14, O60635, O60745, Q5VST0
    Related
    ENSP00000361072.1, ENST00000372003.6
    Conserved Domains (1) summary
    pfam00335
    Location:7 → 236
    Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    46175087..46196489
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047421003.1 → XP_047276959.1  tetraspanin-1 isoform X1

  2. XM_047420922.1 → XP_047276878.1  tetraspanin-1 isoform X1

  3. XM_047420982.1 → XP_047276938.1  tetraspanin-1 isoform X1

  4. XM_047420887.1 → XP_047276843.1  tetraspanin-1 isoform X1

  5. XM_047420946.1 → XP_047276902.1  tetraspanin-1 isoform X1

  6. XM_011540460.4 → XP_011538762.1  tetraspanin-1 isoform X1

    Conserved Domains (2) summary
    cd03156
    Location:110 → 212
    uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:7 → 214
    Tetraspannin; Tetraspanin family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    46052282..46073710
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054333729.1 → XP_054189704.1  tetraspanin-1 isoform X1

  2. XM_054333726.1 → XP_054189701.1  tetraspanin-1 isoform X1

  3. XM_054333728.1 → XP_054189703.1  tetraspanin-1 isoform X1

  4. XM_054333725.1 → XP_054189700.1  tetraspanin-1 isoform X1

  5. XM_054333727.1 → XP_054189702.1  tetraspanin-1 isoform X1

  6. XM_054333724.1 → XP_054189699.1  tetraspanin-1 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O60635.2 GenPept UniProtKB/Swiss-Prot:O60635

Gene LinkOut

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