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WRN WRN RecQ like helicase [ Papio anubis (olive baboon) ]

Gene ID: 101014667, updated on 8-Mar-2024

Summary

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Gene symbol
WRN
Gene description
WRN RecQ like helicase
See related
Ensembl:ENSPANG00000018594
Gene type
protein coding
RefSeq status
MODEL
Organism
Papio anubis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Papio
Orthologs
human mouse all
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Genomic context

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See WRN in Genome Data Viewer
Location:
chromosome: 8
Exon count:
43
Annotation release Status Assembly Chr Location
104 current Panubis1.0 (GCF_008728515.1) 8 NC_044983.1 (29274054..29419278)
103 previous assembly Panu_3.0 (GCF_000264685.3) 8 NC_018159.2 (29258949..29404304)

Chromosome 8 - NC_044983.1Genomic Context describing neighboring genes Neighboring gene testis expressed 15, meiosis and synapsis associated Neighboring gene acyl-CoA:lysophosphatidylglycerol acyltransferase 1 pseudogene Neighboring gene purine rich element binding protein G Neighboring gene BTB/POZ domain-containing protein KCTD9 pseudogene Neighboring gene uncharacterized LOC103886721

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 3'-5' DNA helicase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables 3'-5' exonuclease activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables four-way junction helicase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in DNA unwinding involved in DNA replication IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in G-quadruplex DNA unwinding IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in telomere maintenance IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
Werner syndrome ATP-dependent helicase
Names
Werner syndrome RecQ like helicase

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Papio anubis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Panubis1.0 Primary Assembly

Genomic

  1. NC_044983.1 Reference Panubis1.0 Primary Assembly

    Range
    29274054..29419278
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_031669469.1 → XP_031525329.1  Werner syndrome ATP-dependent helicase isoform X1

    UniProtKB/TrEMBL
    A0A8I5NXP2
    Related
    ENSPANP00000049349.1, ENSPANT00000068959.1
    Conserved Domains (5) summary
    smart00341
    Location:1151 → 1229
    HRDC; Helicase and RNase D C-terminal
    TIGR00614
    Location:537 → 1010
    recQ_fam; ATP-dependent DNA helicase, RecQ family
    PTZ00341
    Location:335 → 480
    PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
    cd06129
    Location:61 → 229
    RNaseD_like; DEDDy 3'-5' exonuclease domain of RNase D, WRN, and similar proteins
    pfam14493
    Location:1258 → 1352
    HTH_40; Helix-turn-helix domain

  2. XM_031669478.1 → XP_031525338.1  Werner syndrome ATP-dependent helicase isoform X5

    UniProtKB/TrEMBL
    A0A8I5NJ95
    Conserved Domains (4) summary
    smart00341
    Location:1151 → 1229
    HRDC; Helicase and RNase D C-terminal
    TIGR00614
    Location:537 → 1010
    recQ_fam; ATP-dependent DNA helicase, RecQ family
    PTZ00341
    Location:335 → 480
    PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
    cd06129
    Location:61 → 229
    RNaseD_like; DEDDy 3'-5' exonuclease domain of RNase D, WRN, and similar proteins

  3. XM_031669468.1 → XP_031525328.1  Werner syndrome ATP-dependent helicase isoform X1

    UniProtKB/TrEMBL
    A0A8I5NXP2
    Conserved Domains (5) summary
    smart00341
    Location:1151 → 1229
    HRDC; Helicase and RNase D C-terminal
    TIGR00614
    Location:537 → 1010
    recQ_fam; ATP-dependent DNA helicase, RecQ family
    PTZ00341
    Location:335 → 480
    PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
    cd06129
    Location:61 → 229
    RNaseD_like; DEDDy 3'-5' exonuclease domain of RNase D, WRN, and similar proteins
    pfam14493
    Location:1258 → 1352
    HTH_40; Helix-turn-helix domain

  4. XM_031669471.1 → XP_031525331.1  Werner syndrome ATP-dependent helicase isoform X1

    UniProtKB/TrEMBL
    A0A8I5NXP2
    Conserved Domains (5) summary
    smart00341
    Location:1151 → 1229
    HRDC; Helicase and RNase D C-terminal
    TIGR00614
    Location:537 → 1010
    recQ_fam; ATP-dependent DNA helicase, RecQ family
    PTZ00341
    Location:335 → 480
    PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
    cd06129
    Location:61 → 229
    RNaseD_like; DEDDy 3'-5' exonuclease domain of RNase D, WRN, and similar proteins
    pfam14493
    Location:1258 → 1352
    HTH_40; Helix-turn-helix domain

  5. XM_031669476.1 → XP_031525336.1  Werner syndrome ATP-dependent helicase isoform X3

    UniProtKB/TrEMBL
    A0A8I5NJP4, A0A8I5NTT3
    Related
    ENSPANP00000052821.1, ENSPANT00000060987.1
    Conserved Domains (5) summary
    smart00341
    Location:1151 → 1229
    HRDC; Helicase and RNase D C-terminal
    TIGR00614
    Location:537 → 1010
    recQ_fam; ATP-dependent DNA helicase, RecQ family
    PTZ00341
    Location:335 → 480
    PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
    cd06129
    Location:61 → 229
    RNaseD_like; DEDDy 3'-5' exonuclease domain of RNase D, WRN, and similar proteins
    pfam14493
    Location:1258 → 1352
    HTH_40; Helix-turn-helix domain

  6. XM_031669470.1 → XP_031525330.1  Werner syndrome ATP-dependent helicase isoform X1

    UniProtKB/TrEMBL
    A0A8I5NXP2
    Conserved Domains (5) summary
    smart00341
    Location:1151 → 1229
    HRDC; Helicase and RNase D C-terminal
    TIGR00614
    Location:537 → 1010
    recQ_fam; ATP-dependent DNA helicase, RecQ family
    PTZ00341
    Location:335 → 480
    PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
    cd06129
    Location:61 → 229
    RNaseD_like; DEDDy 3'-5' exonuclease domain of RNase D, WRN, and similar proteins
    pfam14493
    Location:1258 → 1352
    HTH_40; Helix-turn-helix domain

  7. XM_031669473.1 → XP_031525333.1  Werner syndrome ATP-dependent helicase isoform X1

    UniProtKB/TrEMBL
    A0A8I5NXP2
    Conserved Domains (5) summary
    smart00341
    Location:1151 → 1229
    HRDC; Helicase and RNase D C-terminal
    TIGR00614
    Location:537 → 1010
    recQ_fam; ATP-dependent DNA helicase, RecQ family
    PTZ00341
    Location:335 → 480
    PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
    cd06129
    Location:61 → 229
    RNaseD_like; DEDDy 3'-5' exonuclease domain of RNase D, WRN, and similar proteins
    pfam14493
    Location:1258 → 1352
    HTH_40; Helix-turn-helix domain

  8. XM_031669477.1 → XP_031525337.1  Werner syndrome ATP-dependent helicase isoform X4

    UniProtKB/TrEMBL
    A0A8I5NXP2
    Conserved Domains (5) summary
    smart00341
    Location:1081 → 1159
    HRDC; Helicase and RNase D C-terminal
    TIGR00614
    Location:467 → 940
    recQ_fam; ATP-dependent DNA helicase, RecQ family
    PTZ00341
    Location:265 → 410
    PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
    cd06129
    Location:4 → 159
    RNaseD_like; DEDDy 3'-5' exonuclease domain of RNase D, WRN, and similar proteins
    pfam14493
    Location:1188 → 1282
    HTH_40; Helix-turn-helix domain

  9. XM_031669472.1 → XP_031525332.1  Werner syndrome ATP-dependent helicase isoform X1

    UniProtKB/TrEMBL
    A0A8I5NXP2
    Conserved Domains (5) summary
    smart00341
    Location:1151 → 1229
    HRDC; Helicase and RNase D C-terminal
    TIGR00614
    Location:537 → 1010
    recQ_fam; ATP-dependent DNA helicase, RecQ family
    PTZ00341
    Location:335 → 480
    PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
    cd06129
    Location:61 → 229
    RNaseD_like; DEDDy 3'-5' exonuclease domain of RNase D, WRN, and similar proteins
    pfam14493
    Location:1258 → 1352
    HTH_40; Helix-turn-helix domain

  10. XM_031669474.1 → XP_031525334.1  Werner syndrome ATP-dependent helicase isoform X1

    UniProtKB/TrEMBL
    A0A8I5NXP2
    Conserved Domains (5) summary
    smart00341
    Location:1151 → 1229
    HRDC; Helicase and RNase D C-terminal
    TIGR00614
    Location:537 → 1010
    recQ_fam; ATP-dependent DNA helicase, RecQ family
    PTZ00341
    Location:335 → 480
    PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
    cd06129
    Location:61 → 229
    RNaseD_like; DEDDy 3'-5' exonuclease domain of RNase D, WRN, and similar proteins
    pfam14493
    Location:1258 → 1352
    HTH_40; Helix-turn-helix domain

  11. XM_031669475.1 → XP_031525335.1  Werner syndrome ATP-dependent helicase isoform X2

    UniProtKB/TrEMBL
    A0A096NYG9, A0A8I5NXP2
    Related
    ENSPANP00000018132.3, ENSPANT00000010667.3
    Conserved Domains (5) summary
    smart00341
    Location:1151 → 1229
    HRDC; Helicase and RNase D C-terminal
    TIGR00614
    Location:537 → 1010
    recQ_fam; ATP-dependent DNA helicase, RecQ family
    PTZ00341
    Location:335 → 480
    PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
    cd06129
    Location:61 → 229
    RNaseD_like; DEDDy 3'-5' exonuclease domain of RNase D, WRN, and similar proteins
    pfam14493
    Location:1258 → 1352
    HTH_40; Helix-turn-helix domain

  12. XM_031669479.1 → XP_031525339.1  Werner syndrome ATP-dependent helicase isoform X6

    UniProtKB/TrEMBL
    A0A8I5NXP2
    Conserved Domains (4) summary
    smart00341
    Location:902 → 980
    HRDC; Helicase and RNase D C-terminal
    TIGR00614
    Location:288 → 761
    recQ_fam; ATP-dependent DNA helicase, RecQ family
    PTZ00341
    Location:86 → 231
    PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
    pfam14493
    Location:1009 → 1103
    HTH_40; Helix-turn-helix domain

RNA

  1. XR_004185790.1 RNA Sequence

  2. XR_004185787.1 RNA Sequence

  3. XR_004185786.1 RNA Sequence

  4. XR_004185788.1 RNA Sequence

  5. XR_004185789.1 RNA Sequence

  6. XR_004185785.1 RNA Sequence

Nucleotide Protein
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