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HSPG2 heparan sulfate proteoglycan 2 [ Papio anubis (olive baboon) ]

Gene ID: 101006455, updated on 8-Mar-2024

Summary

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Gene symbol
HSPG2
Gene description
heparan sulfate proteoglycan 2
See related
Ensembl:ENSPANG00000008046
Gene type
protein coding
RefSeq status
MODEL
Organism
Papio anubis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Papio
Orthologs
human mouse all
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Genomic context

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See HSPG2 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
99
Annotation release Status Assembly Chr Location
104 current Panubis1.0 (GCF_008728515.1) 1 NC_044976.1 (20039035..20154867, complement)
103 previous assembly Panu_3.0 (GCF_000264685.3) 1 NC_018152.2 (20111853..20227431, complement)

Chromosome 1 - NC_044976.1Genomic Context describing neighboring genes Neighboring gene RAP1 GTPase activating protein Neighboring gene ubiquitin specific peptidase 48 Neighboring gene U7 small nuclear RNA Neighboring gene low density lipoprotein receptor class A domain containing 2 Neighboring gene serine/threonine-protein phosphatase 4 regulatory subunit 3-like Neighboring gene 60S ribosomal protein L31 pseudogene Neighboring gene U6 spliceosomal RNA Neighboring gene chymotrypsin like elastase 3B Neighboring gene uncharacterized LOC103882166

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cell adhesion molecule binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cell-cell junction IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
basement membrane-specific heparan sulfate proteoglycan core protein

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Papio anubis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Panubis1.0 Primary Assembly

Genomic

  1. NC_044976.1 Reference Panubis1.0 Primary Assembly

    Range
    20039035..20154867 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021937073.2 → XP_021792765.2  basement membrane-specific heparan sulfate proteoglycan core protein isoform X6

    UniProtKB/TrEMBL
    A0A096N531
    Related
    ENSPANP00000007536.3, ENSPANT00000015076.4
    Conserved Domains (16) summary
    cd05743
    Location:421 → 498
    Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2, and similar domains
    cd05754
    Location:1771 → 1856
    Ig_Perlecan_like; Igmmunoglobulin (Ig)-like domain found in Perlecan and similar proteins
    smart00200
    Location:80 → 194
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    smart00281
    Location:985 → 1112
    LamB; Laminin B domain
    smart00409
    Location:2158 → 2235
    IG; Immunoglobulin
    smart00410
    Location:2057 → 2134
    IG_like; Immunoglobulin like
    cd00054
    Location:3852 → 3881
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:1158 → 1207
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:4203 → 4362
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00112
    Location:285 → 319
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00008
    Location:4108 → 4138
    EGF; EGF-like domain
    pfam00052
    Location:1396 → 1528
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:1275 → 1322
    Laminin_EGF; Laminin EGF domain
    pfam00057
    Location:197 → 234
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam07679
    Location:3581 → 3658
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:3221 → 3295
    Ig; Immunoglobulin domain

  2. XM_021937071.2 → XP_021792763.2  basement membrane-specific heparan sulfate proteoglycan core protein isoform X5

    Conserved Domains (16) summary
    cd05743
    Location:421 → 498
    Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2, and similar domains
    cd05754
    Location:1772 → 1857
    Ig_Perlecan_like; Igmmunoglobulin (Ig)-like domain found in Perlecan and similar proteins
    smart00200
    Location:80 → 194
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    smart00281
    Location:986 → 1113
    LamB; Laminin B domain
    smart00409
    Location:2159 → 2236
    IG; Immunoglobulin
    smart00410
    Location:2058 → 2135
    IG_like; Immunoglobulin like
    cd00054
    Location:3853 → 3882
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:1159 → 1208
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:4204 → 4363
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00112
    Location:285 → 319
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00008
    Location:4109 → 4139
    EGF; EGF-like domain
    pfam00052
    Location:1397 → 1529
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:1276 → 1323
    Laminin_EGF; Laminin EGF domain
    pfam00057
    Location:197 → 234
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam07679
    Location:3582 → 3659
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:3222 → 3296
    Ig; Immunoglobulin domain

  3. XM_021937069.2 → XP_021792761.2  basement membrane-specific heparan sulfate proteoglycan core protein isoform X4

    Conserved Domains (16) summary
    cd05743
    Location:421 → 498
    Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2, and similar domains
    cd05754
    Location:1772 → 1857
    Ig_Perlecan_like; Igmmunoglobulin (Ig)-like domain found in Perlecan and similar proteins
    smart00200
    Location:80 → 194
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    smart00281
    Location:986 → 1113
    LamB; Laminin B domain
    smart00409
    Location:2058 → 2135
    IG; Immunoglobulin
    smart00410
    Location:2252 → 2326
    IG_like; Immunoglobulin like
    cd00054
    Location:3859 → 3888
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:1159 → 1208
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:4210 → 4369
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00112
    Location:285 → 319
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00008
    Location:4115 → 4145
    EGF; EGF-like domain
    pfam00052
    Location:1397 → 1529
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:1276 → 1323
    Laminin_EGF; Laminin EGF domain
    pfam00057
    Location:197 → 234
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam07679
    Location:3582 → 3659
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:3222 → 3296
    Ig; Immunoglobulin domain

  4. XM_021937060.2 → XP_021792752.2  basement membrane-specific heparan sulfate proteoglycan core protein isoform X2

    Conserved Domains (16) summary
    cd05743
    Location:438 → 515
    Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2, and similar domains
    cd05754
    Location:1788 → 1873
    Ig_Perlecan_like; Igmmunoglobulin (Ig)-like domain found in Perlecan and similar proteins
    smart00200
    Location:80 → 193
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    smart00281
    Location:1002 → 1129
    LamB; Laminin B domain
    smart00409
    Location:2175 → 2252
    IG; Immunoglobulin
    smart00410
    Location:2074 → 2151
    IG_like; Immunoglobulin like
    cd00054
    Location:3875 → 3904
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:1175 → 1224
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:4226 → 4385
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00112
    Location:302 → 336
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00008
    Location:4131 → 4161
    EGF; EGF-like domain
    pfam00052
    Location:1413 → 1545
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:1292 → 1339
    Laminin_EGF; Laminin EGF domain
    pfam00057
    Location:214 → 251
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam07679
    Location:3598 → 3675
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:3238 → 3312
    Ig; Immunoglobulin domain

  5. XM_021937074.2 → XP_021792766.2  basement membrane-specific heparan sulfate proteoglycan core protein isoform X7

    Conserved Domains (16) summary
    cd05743
    Location:438 → 515
    Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2, and similar domains
    cd05754
    Location:1789 → 1874
    Ig_Perlecan_like; Igmmunoglobulin (Ig)-like domain found in Perlecan and similar proteins
    smart00200
    Location:80 → 193
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    smart00281
    Location:1003 → 1130
    LamB; Laminin B domain
    smart00409
    Location:2759 → 2835
    IG; Immunoglobulin
    smart00410
    Location:2075 → 2152
    IG_like; Immunoglobulin like
    cd00054
    Location:3783 → 3812
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:1176 → 1225
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:4134 → 4293
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00112
    Location:302 → 336
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00008
    Location:4039 → 4069
    EGF; EGF-like domain
    pfam00052
    Location:1414 → 1546
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:1293 → 1340
    Laminin_EGF; Laminin EGF domain
    pfam00057
    Location:214 → 251
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam07679
    Location:3506 → 3583
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:3146 → 3220
    Ig; Immunoglobulin domain

  6. XM_021937064.2 → XP_021792756.2  basement membrane-specific heparan sulfate proteoglycan core protein isoform X3

    Conserved Domains (16) summary
    cd05743
    Location:438 → 515
    Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2, and similar domains
    cd05754
    Location:1789 → 1874
    Ig_Perlecan_like; Igmmunoglobulin (Ig)-like domain found in Perlecan and similar proteins
    smart00200
    Location:80 → 193
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    smart00281
    Location:1003 → 1130
    LamB; Laminin B domain
    smart00409
    Location:2176 → 2253
    IG; Immunoglobulin
    smart00410
    Location:2075 → 2152
    IG_like; Immunoglobulin like
    cd00054
    Location:3870 → 3899
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:1176 → 1225
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:4221 → 4380
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00112
    Location:302 → 336
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00008
    Location:4126 → 4156
    EGF; EGF-like domain
    pfam00052
    Location:1414 → 1546
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:1293 → 1340
    Laminin_EGF; Laminin EGF domain
    pfam00057
    Location:214 → 251
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam07679
    Location:3599 → 3676
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:3239 → 3313
    Ig; Immunoglobulin domain

  7. XM_009201305.4 → XP_009199569.3  basement membrane-specific heparan sulfate proteoglycan core protein isoform X1

    Conserved Domains (16) summary
    cd05743
    Location:438 → 515
    Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2, and similar domains
    cd05754
    Location:1789 → 1874
    Ig_Perlecan_like; Igmmunoglobulin (Ig)-like domain found in Perlecan and similar proteins
    smart00200
    Location:80 → 193
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    smart00281
    Location:1003 → 1130
    LamB; Laminin B domain
    smart00409
    Location:2176 → 2253
    IG; Immunoglobulin
    smart00410
    Location:2075 → 2152
    IG_like; Immunoglobulin like
    cd00054
    Location:3876 → 3905
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:1176 → 1225
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:4227 → 4386
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00112
    Location:302 → 336
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00008
    Location:4132 → 4162
    EGF; EGF-like domain
    pfam00052
    Location:1414 → 1546
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:1293 → 1340
    Laminin_EGF; Laminin EGF domain
    pfam00057
    Location:214 → 251
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam07679
    Location:3599 → 3676
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:3239 → 3313
    Ig; Immunoglobulin domain
Nucleotide Protein
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