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PLCG2 phospholipase C gamma 2 [ Papio anubis (olive baboon) ]

Gene ID: 101004091, updated on 8-Mar-2024

Summary

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Gene symbol
PLCG2
Gene description
phospholipase C gamma 2
See related
Ensembl:ENSPANG00000021730
Gene type
protein coding
RefSeq status
MODEL
Organism
Papio anubis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Papio
Orthologs
human mouse all
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Genomic context

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See PLCG2 in Genome Data Viewer
Location:
chromosome: 18
Exon count:
34
Annotation release Status Assembly Chr Location
104 current Panubis1.0 (GCF_008728515.1) 18 NC_044993.1 (8025319..8209644, complement)
103 previous assembly Panu_3.0 (GCF_000264685.3) 20 NC_018171.2 (63728533..63913055)

Chromosome 18 - NC_044993.1Genomic Context describing neighboring genes Neighboring gene hydroxysteroid 17-beta dehydrogenase 2 Neighboring gene uncharacterized LOC110742066 Neighboring gene short chain dehydrogenase/reductase family 42E, member 1 Neighboring gene uncharacterized LOC116271264 Neighboring gene c-Maf inducing protein Neighboring gene uncharacterized LOC110742065 Neighboring gene gigaxonin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables phosphatidylinositol phospholipase C activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in phosphatidylinositol-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phospholipid catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of epithelial cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Papio anubis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Panubis1.0 Primary Assembly

Genomic

  1. NC_044993.1 Reference Panubis1.0 Primary Assembly

    Range
    8025319..8209644 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021932204.2 → XP_021787896.2  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X2

    UniProtKB/TrEMBL
    A0A8I5R1P2
    Conserved Domains (10) summary
    cd00275
    Location:1022 → 1148
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08592
    Location:272 → 419
    PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma
    cd09932
    Location:602 → 705
    SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
    cd10341
    Location:488 → 588
    SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
    cd11969
    Location:734 → 788
    SH3_PLCgamma2; Src homology 3 domain of Phospholipase C (PLC) gamma 2
    cd13234
    Location:801 → 871
    PHsplit_PLC_gamma; Phospholipase C-gamma Split pleckstrin homology (PH) domain
    cd13362
    Location:22 → 140
    PH_PLC_gamma; Phospholipase C-gamma (PLC-gamma) pleckstrin homology (PH) domain
    cl28895
    Location:145 → 259
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    cl14615
    Location:887 → 992
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl17171
    Location:436 → 471
    PH-like; Pleckstrin homology-like domain

  2. XM_009196941.3 → XP_009195205.2  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1

    UniProtKB/TrEMBL
    A0A096NBT6, A0A8I5R1P2
    Related
    ENSPANP00000010241.2, ENSPANT00000005706.3
    Conserved Domains (10) summary
    cd00275
    Location:1061 → 1187
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08592
    Location:311 → 458
    PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma
    cd09932
    Location:641 → 744
    SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
    cd10341
    Location:527 → 627
    SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
    cd11969
    Location:773 → 827
    SH3_PLCgamma2; Src homology 3 domain of Phospholipase C (PLC) gamma 2
    cd13234
    Location:840 → 910
    PHsplit_PLC_gamma; Phospholipase C-gamma Split pleckstrin homology (PH) domain
    cd13362
    Location:22 → 140
    PH_PLC_gamma; Phospholipase C-gamma (PLC-gamma) pleckstrin homology (PH) domain
    cd16215
    Location:145 → 298
    EFh_PI-PLCgamma2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
    cl14615
    Location:926 → 1031
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl17171
    Location:475 → 510
    PH-like; Pleckstrin homology-like domain

  3. XM_003917231.4 → XP_003917280.2  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1

    UniProtKB/TrEMBL
    A0A096NBT6, A0A8I5R1P2
    Conserved Domains (10) summary
    cd00275
    Location:1061 → 1187
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08592
    Location:311 → 458
    PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma
    cd09932
    Location:641 → 744
    SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
    cd10341
    Location:527 → 627
    SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
    cd11969
    Location:773 → 827
    SH3_PLCgamma2; Src homology 3 domain of Phospholipase C (PLC) gamma 2
    cd13234
    Location:840 → 910
    PHsplit_PLC_gamma; Phospholipase C-gamma Split pleckstrin homology (PH) domain
    cd13362
    Location:22 → 140
    PH_PLC_gamma; Phospholipase C-gamma (PLC-gamma) pleckstrin homology (PH) domain
    cd16215
    Location:145 → 298
    EFh_PI-PLCgamma2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
    cl14615
    Location:926 → 1031
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl17171
    Location:475 → 510
    PH-like; Pleckstrin homology-like domain

  4. XM_021932209.2 → XP_021787901.2  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X5

    UniProtKB/TrEMBL
    A0A8I5R1P2
    Conserved Domains (9) summary
    cd00275
    Location:852 → 978
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08592
    Location:102 → 249
    PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma
    cd09932
    Location:432 → 535
    SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
    cd10341
    Location:318 → 418
    SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
    cd11969
    Location:564 → 618
    SH3_PLCgamma2; Src homology 3 domain of Phospholipase C (PLC) gamma 2
    cd13234
    Location:631 → 701
    PHsplit_PLC_gamma; Phospholipase C-gamma Split pleckstrin homology (PH) domain
    cl28895
    Location:23 → 89
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    cl14615
    Location:717 → 822
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl17171
    Location:266 → 301
    PH-like; Pleckstrin homology-like domain

  5. XM_021932206.2 → XP_021787898.2  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X3

    UniProtKB/TrEMBL
    A0A8I5R1P2
    Conserved Domains (9) summary
    cd00275
    Location:994 → 1120
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08592
    Location:244 → 391
    PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma
    cd09932
    Location:574 → 677
    SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
    cd10341
    Location:460 → 560
    SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
    cd11969
    Location:706 → 760
    SH3_PLCgamma2; Src homology 3 domain of Phospholipase C (PLC) gamma 2
    cd13234
    Location:773 → 843
    PHsplit_PLC_gamma; Phospholipase C-gamma Split pleckstrin homology (PH) domain
    cd16215
    Location:78 → 231
    EFh_PI-PLCgamma2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
    cl14615
    Location:859 → 964
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl17171
    Location:1 → 73
    PH-like; Pleckstrin homology-like domain

  6. XM_021932207.2 → XP_021787899.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X4

    UniProtKB/TrEMBL
    A0A8I5R1P2
    Conserved Domains (10) summary
    cd00275
    Location:1061 → 1187
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08592
    Location:311 → 458
    PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma
    cd09932
    Location:641 → 744
    SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
    cd10341
    Location:527 → 627
    SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
    cd11969
    Location:773 → 827
    SH3_PLCgamma2; Src homology 3 domain of Phospholipase C (PLC) gamma 2
    cd13234
    Location:840 → 910
    PHsplit_PLC_gamma; Phospholipase C-gamma Split pleckstrin homology (PH) domain
    cd13362
    Location:22 → 140
    PH_PLC_gamma; Phospholipase C-gamma (PLC-gamma) pleckstrin homology (PH) domain
    cd16215
    Location:145 → 298
    EFh_PI-PLCgamma2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
    cl14615
    Location:926 → 1031
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl17171
    Location:475 → 510
    PH-like; Pleckstrin homology-like domain

RNA

  1. XR_002519326.2 RNA Sequence

Nucleotide Protein
Heading Accession and Version

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