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SPDYE11 speedy/RINGO cell cycle regulator family member E11 [ Homo sapiens (human) ]

Gene ID: 100996746, updated on 23-Nov-2023

Summary

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Official Symbol
SPDYE11provided by HGNC
Official Full Name
speedy/RINGO cell cycle regulator family member E11provided by HGNC
Primary source
HGNC:HGNC:51507
See related
Ensembl:ENSG00000275976 AllianceGenome:HGNC:51507
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables acetylcholine receptor regulator activity. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 9.9), skin (RPKM 2.8) and 23 other tissues See more
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Genomic context

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Location:
7q11.23
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (73047862..73057911, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 (PATCHES) NW_003871064.1 (577098..587147, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene speedy/RINGO cell cycle regulator family member E8 Neighboring gene PMS1 homolog 2, mismatch repair system component pseudogene 8 Neighboring gene PMS1 homolog 2, mismatch repair system component pseudogene 14 Neighboring gene speedy/RINGO cell cycle regulator family member E9 Neighboring gene PMS1 homolog 2, mismatch repair system component pseudogene 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A Genome-Wide Arrayed cDNA Screen to Identify Functional Modulators of α7 Nicotinic Acetylcholine Receptors. Rex EB, et al. SLAS Discov, 2017 Feb. PMID 27789755
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables acetylcholine receptor regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
putative speedy protein E11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001351349.3 → NP_001338278.1  putative speedy protein E11

    Status: VALIDATED

    Source sequence(s)
    AC211476
    Consensus CDS
    CCDS94115.1
    UniProtKB/Swiss-Prot
    A0A494C191, P0DTA3, P0DUD1, P0DUD2, P0DUX0
    Related
    ENSP00000498510.1, ENST00000340073.9
    Conserved Domains (1) summary
    pfam11357
    Location:107 → 261
    Spy1; Cell cycle regulatory protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    73047862..73057911 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0DTA3.1 GenPept UniProtKB/Swiss-Prot:P0DTA3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials