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GM2A ganglioside GM2 activator [ Pan paniscus (pygmy chimpanzee) ]

Gene ID: 100992489, updated on 8-Mar-2024

Summary

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Gene symbol
GM2A
Gene description
ganglioside GM2 activator
See related
Ensembl:ENSPPAG00000037388
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan paniscus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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See GM2A in Genome Data Viewer
Location:
chromosome: 4
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanPan1-v2.0_pri (GCF_029289425.2) 4 NC_073253.2 (146484984..146501347)
RS_2023_05 previous assembly NHGRI_mPanPan1-v1.1-0.1.freeze_pri (GCF_029289425.1) 5 NC_073254.1 (144624529..144640892)

Chromosome 4 - NC_073253.2Genomic Context describing neighboring genes Neighboring gene annexin A6 Neighboring gene coiled-coil domain containing 69 Neighboring gene solute carrier family 36 member 3 Neighboring gene solute carrier family 36 member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables enzyme activator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables lipid transporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in ganglioside catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasmic side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
ganglioside GM2 activator
Names
GM2 ganglioside activator

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_029289425.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanPan1-v2.0_pri Primary Assembly

Genomic

  1. NC_073253.2 Reference NHGRI_mPanPan1-v2.0_pri Primary Assembly

    Range
    146484984..146501347
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003828995.5 → XP_003829043.1  ganglioside GM2 activator

    See identical proteins and their annotated locations for XP_003829043.1

    UniProtKB/TrEMBL
    A0A2R9BHB2
    Related
    ENSPPAP00000028698.1
    Conserved Domains (1) summary
    cd00258
    Location:32 → 193
    GM2-AP; GM2 activator protein (GM2-AP) is a non-enzymatic lysosomal protein that acts as cofactor in the sequential degradation of gangliosides. GM2A is an essential cofactor for beta-hexosaminidase A (Hex A) in the enzymatic hydrolysis of GM2 ganglioside to GM3. ...
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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