F8 coagulation factor VIII [Pan paniscus (pygmy chimpanzee)] - Gene

Summary

Gene symbol: F8
Gene description: coagulation factor VIII
See related: Ensembl:ENSPPAG00000033513
Gene type: protein coding
RefSeq status: MODEL
Organism: Pan paniscus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: X

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanPan1-v2.0_pri (GCF_029289425.2)	X	NC_073272.2 (154815145..155000578, complement)
RS_2023_05	previous assembly	NHGRI_mPanPan1-v1.1-0.1.freeze_pri (GCF_029289425.1)	X	NC_073272.1 (154820124..155004186, complement)

Chromosome X - NC_073272.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables copper ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables signaling receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: coagulation factor VIII

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_029289425.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanPan1-v2.0_pri Primary Assembly

Genomic

NC_073272.2 Reference NHGRI_mPanPan1-v2.0_pri Primary Assembly

Range

154815145..155000578 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_003809957.4 → XP_003810005.2 coagulation factor VIII isoform X1

UniProtKB/TrEMBL

A0A2R9ATQ4

Conserved Domains (7) summary

cd00057
Location:2195 → 2344

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cd04227
Location:399 → 575

CuRO_3_FVIII_like; The third cupredoxin domain of coagulation factor VIII and similar proteins

cd04228
Location:1714 → 1880

CuRO_5_FVIII_like; The fifth cupredoxin domain of coagulation factor VIII and similar proteins

cd11015
Location:211 → 345

CuRO_2_FVIII_like; The second cupredoxin domain of coagulation factor VIII and similar proteins

cd11016
Location:588 → 730

CuRO_4_FVIII_like; The fourth cupredoxin domain of coagulation factor VIII and similar proteins

cd11018
Location:1892 → 2035

CuRO_6_FVIII_like; The sixth cupredoxin domain of coagulation factor VIII and similar proteins

cd14452
Location:22 → 201

CuRO_1_FVIII_like; The first cupredoxin domain of coagulation factor VIII and similar proteins
XM_008962334.4 → XP_008960582.2 coagulation factor VIII isoform X2

UniProtKB/TrEMBL

A0A2R9ATE1

Conserved Domains (2) summary

cd00057
Location:133 → 282

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cl25480
Location:75 → 125

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.