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SHMT2 serine hydroxymethyltransferase 2 [ Pan paniscus (pygmy chimpanzee) ]

Gene ID: 100985606, updated on 8-Mar-2024

Summary

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Gene symbol
SHMT2
Gene description
serine hydroxymethyltransferase 2
See related
Ensembl:ENSPPAG00000033906
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan paniscus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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See SHMT2 in Genome Data Viewer
Location:
chromosome: 10
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanPan1-v2.0_pri (GCF_029289425.2) 10 NC_073259.2 (37106967..37112419, complement)
RS_2023_05 previous assembly NHGRI_mPanPan1-v1.1-0.1.freeze_pri (GCF_029289425.1) 12 NC_073261.1 (37103737..37108804, complement)

Chromosome 10 - NC_073259.2Genomic Context describing neighboring genes Neighboring gene SH3 and cysteine rich domain 3 Neighboring gene NDUFA4 mitochondrial complex associated like 2 Neighboring gene neurexophilin 4 Neighboring gene LDL receptor related protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cobalt ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables glycine hydroxymethyltransferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables serine binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in L-serine catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in folic acid metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in glycine biosynthetic process from serine IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of oxidative phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to type I interferon IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in tetrahydrofolate interconversion IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of BRISC complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
serine hydroxymethyltransferase, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_029289425.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanPan1-v2.0_pri Primary Assembly

Genomic

  1. NC_073259.2 Reference NHGRI_mPanPan1-v2.0_pri Primary Assembly

    Range
    37106967..37112419 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003824872.6 → XP_003824920.1  serine hydroxymethyltransferase, mitochondrial isoform X3

    See identical proteins and their annotated locations for XP_003824920.1

    UniProtKB/TrEMBL
    A0A2R9AVY3
    Related
    ENSPPAP00000021426.1
    Conserved Domains (1) summary
    PLN03226
    Location:45 → 502
    PLN03226; serine hydroxymethyltransferase; Provisional

  2. XM_008978526.3 → XP_008976774.1  serine hydroxymethyltransferase, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_008976774.1

    Conserved Domains (2) summary
    PLN03226
    Location:106 → 504
    PLN03226; serine hydroxymethyltransferase; Provisional
    cl18945
    Location:105 → 450
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

  3. XM_003824877.7 → XP_003824925.1  serine hydroxymethyltransferase, mitochondrial isoform X1

    Conserved Domains (2) summary
    PLN03226
    Location:113 → 511
    PLN03226; serine hydroxymethyltransferase; Provisional
    cl18945
    Location:112 → 457
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

  4. XM_003824874.5 → XP_003824922.1  serine hydroxymethyltransferase, mitochondrial isoform X4

    Conserved Domains (1) summary
    PLN03226
    Location:24 → 481
    PLN03226; serine hydroxymethyltransferase; Provisional

  5. XM_034935615.2 → XP_034791506.1  serine hydroxymethyltransferase, mitochondrial isoform X5

    Conserved Domains (1) summary
    cl18945
    Location:101 → 406
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

  6. XM_034935614.2 → XP_034791505.1  serine hydroxymethyltransferase, mitochondrial isoform X5

    Conserved Domains (1) summary
    cl18945
    Location:101 → 406
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
Nucleotide Protein
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