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ACAN aggrecan [ Sarcophilus harrisii (Tasmanian devil) ]

Gene ID: 100933517, updated on 8-Mar-2024

Summary

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Gene symbol
ACAN
Gene description
aggrecan
Gene type
protein coding
RefSeq status
MODEL
Organism
Sarcophilus harrisii
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus
Orthologs
human mouse all
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Genomic context

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See ACAN in Genome Data Viewer
Location:
chromosome: 2
Exon count:
20
Annotation release Status Assembly Chr Location
103 current mSarHar1.11 (GCF_902635505.1) 2 NC_045427.1 (546382439..546471598)
102 previous assembly Devil_ref v7.0 (GCF_000189315.1) 1 Unlocalized Scaffold NW_003816482.1 (2176232..2217709, complement)

Chromosome 2 - NC_045427.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC116421862 Neighboring gene apoptosis enhancing nuclease Neighboring gene interferon stimulated exonuclease gene 20 Neighboring gene hyaluronan and proteoglycan link protein 3 Neighboring gene milk fat globule EGF and factor V/VIII domain containing

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables hyaluronic acid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
aggrecan core protein

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Sarcophilus harrisii Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mSarHar1.11 Primary Assembly

Genomic

  1. NC_045427.1 Reference mSarHar1.11 Primary Assembly

    Range
    546382439..546471598
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_031955572.1 → XP_031811432.1  aggrecan core protein

    Conserved Domains (8) summary
    cd00033
    Location:2110 → 2167
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd03588
    Location:1983 → 2106
    CLECT_CSPGs; C-type lectin-like domain (CTLD) of the type found in chondroitin sulfate proteoglycan core proteins
    PHA03307
    Location:730 → 1138
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00054
    Location:1941 → 1977
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd03517
    Location:153 → 247
    Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: versican, neurocan, and brevican. ...
    cd03520
    Location:254 → 349
    Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The link domain is a hyaluronan ...
    pfam05109
    Location:1462 → 1883
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cd05900
    Location:33 → 155
    Ig_Aggrecan; Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), aggrecan
Nucleotide Protein
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