HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 [Capra hircus (goat)] - Gene

Summary

Gene symbol: HMGCS2
Gene description: 3-hydroxy-3-methylglutaryl-CoA synthase 2
See related: EnsemblRapid:ENSCHIG00000025654
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Capra hircus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Capra
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
102	current	ASM170441v1 (GCF_001704415.1)	3	NC_030810.1 (96993773..97024594, complement)
101	previous assembly	CHIR_1.0 (GCF_000317765.1)	3	NC_022295.1 (21493779..21524417)

Chromosome 3 - NC_030810.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables hydroxymethylglutaryl-CoA synthase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in acetyl-CoA metabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in farnesyl diphosphate biosynthetic process, mevalonate pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrion	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: hydroxymethylglutaryl-CoA synthase, mitochondrial

Names: 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2

NP_001272669.1

EC 2.3.3.10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001285740.1 → NP_001272669.1 hydroxymethylglutaryl-CoA synthase, mitochondrial

See identical proteins and their annotated locations for NP_001272669.1

Status: PROVISIONAL

Source sequence(s)

GU586190

UniProtKB/TrEMBL

A0A452G3S1, D4P8J3

Related

ENSCHIP00000050881.1, ENSCHIT00000050363.1

Conserved Domains (3) summary

TIGR01833
Location:50 → 506

HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade

pfam01154
Location:53 → 223

HMG_CoA_synt_N; Hydroxymethylglutaryl-coenzyme A synthase N terminal

pfam08540
Location:224 → 506

HMG_CoA_synt_C; Hydroxymethylglutaryl-coenzyme A synthase C terminal