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CSN2 casein beta [ Capra hircus (goat) ]

Gene ID: 100860784, updated on 1-Aug-2024

Summary

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Gene symbol
CSN2
Gene description
casein beta
See related
EnsemblRapid:ENSCHIG00000021841
Gene type
protein coding
RefSeq status
MODEL
Organism
Capra hircus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Capra
Orthologs
human mouse all
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Genomic context

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See CSN2 in Genome Data Viewer
Location:
chromosome: 6
Exon count:
9
Annotation release Status Assembly Chr Location
102 current ASM170441v1 (GCF_001704415.1) 6 NC_030813.1 (86006250..86015321, complement)
101 previous assembly CHIR_1.0 (GCF_000317765.1) 6 NC_022298.1 (82704636..82713707, complement)

Chromosome 6 - NC_030813.1Genomic Context describing neighboring genes Neighboring gene estrogen sulfotransferase Neighboring gene casein alpha s1 Neighboring gene transfer RNA cysteine (anticodon ACA) Neighboring gene as2-casein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The SNP g.1311T>C associated with the absence of β-casein in goat milk influences CSN2 promoter activity. Cosenza G, et al. Anim Genet, 2016 Oct. PMID 27392512
  2. Genetic polymorphism of CSN2 gene in Banat White and Carpatina goats. Kusza S, et al. Acta Biochim Pol, 2016. PMID 27382646
  3. Relative quantification of beta-casein expression in primary goat mammary epithelial cell lines. Ogorevc J, et al. Genet Mol Res, 2015 Apr 15. PMID 25966115
  4. A functional study of proximal goat β-casein promoter and intron 1 in immortalized goat mammary epithelial cells. Kung MH, et al. J Dairy Sci, 2015 Jun. PMID 25841968
  5. An SNP in the goat CSN2 promoter region is associated with the absence of beta-casein in milk. Cosenza G, et al. Anim Genet, 2007 Dec. PMID 17931404

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Negative regulation of alphaS1-casein (CSN1S1) improves beta-casein content and reduces allergy potential in goat milk.
    Title: Negative regulation of α(S1)-casein (CSN1S1) improves β-casein content and reduces allergy potential in goat milk.
  2. CSN2 polymorphisms are potential markers for milk production in goats.
    Title: Genetic polymorphism of CSN2 gene in Banat White and Carpatina goats.
  3. the nucleotide C at position 1311 negatively affects the promoter activity of the CSN2 gene; the SNP g.1311T>C associated with the absence of beta-casein in milk
    Title: The SNP g.1311T>C associated with the absence of β-casein in goat milk influences CSN2 promoter activity.
  4. Data show that the presence of beta-casein (CSN2) transcripts was detected in all samples, including cells originating from non-lactating goat.
    Title: Relative quantification of beta-casein expression in primary goat mammary epithelial cell lines.
  5. findings demonstrate that the proximal -300 bp of CSN2 promoter containing the STAT5a binding site (-102 to -82) is the response element for lactogenic hormone stimulation; also intron 1 may be required for tissue or developmental stage-specific expression in mammary gland
    Title: A functional study of proximal goat β-casein promoter and intron 1 in immortalized goat mammary epithelial cells.
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General gene information

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Homology

Gene Ontology Provided by RefSeq

Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
beta-casein

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Capra hircus Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM170441v1 Primary Assembly

Genomic

  1. NC_030813.1 Reference ASM170441v1 Primary Assembly

    Range
    86006250..86015321 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_013964699.2 → XP_013820153.1  beta-casein isoform X2

    UniProtKB/TrEMBL
    A0A8C2RDL7, A0AAJ7EMH4
    Conserved Domains (1) summary
    pfam00363
    Location:175 → 245
    Casein; Casein

  2. XM_005681721.2 → XP_005681778.2  beta-casein isoform X1

    UniProtKB/TrEMBL
    A0A8C2RDL7, A0AAJ6WK65
    Related
    ENSCHIP00000024801.2, ENSCHIT00000032661.2
    Conserved Domains (1) summary
    pfam00363
    Location:175 → 245
    Casein; Casein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P33048.1 GenPept UniProtKB/Swiss-Prot:P33048

Gene LinkOut

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