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SCD stearoyl-CoA desaturase [ Capra hircus (goat) ]

Gene ID: 100860763, updated on 8-Mar-2024

Summary

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Gene symbol
SCD
Gene description
stearoyl-CoA desaturase
See related
EnsemblRapid:ENSCHIG00000021254
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Capra hircus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Capra
Also known as
SCD1
Orthologs
human all
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Genomic context

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See SCD in Genome Data Viewer
Location:
chromosome: 26
Exon count:
6
Annotation release Status Assembly Chr Location
102 current ASM170441v1 (GCF_001704415.1) 26 NC_030833.1 (30404780..30415917, complement)
101 previous assembly CHIR_1.0 (GCF_000317765.1) 26 NC_022318.1 (19595743..19606882)

Chromosome 26 - NC_030833.1Genomic Context describing neighboring genes Neighboring gene Wnt family member 8B Neighboring gene elongation factor 1-alpha 1 pseudogene Neighboring gene polycystin 2 like 1, transient receptor potential cation channel Neighboring gene biogenesis of lysosomal organelles complex 1 subunit 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CRISPR/Cas9-mediated Stearoyl-CoA Desaturase 1 (SCD1) Deficiency Affects Fatty Acid Metabolism in Goat Mammary Epithelial Cells. Tian H, et al. J Agric Food Chem, 2018 Sep 26. PMID 30180552
  2. Rapid communication: partial nucleotide sequence of the goat stearoyl coenzyme A desaturase cDNA and gene structure. Yahyaoui MH, et al. J Anim Sci, 2002 Mar. PMID 11890426
  3. Characterization of the caprine stearoyl-CoA desaturase gene and its mRNA showing an unusually long 3'-UTR sequence arising from a single exon. Bernard L, et al. Gene, 2001 Dec 27. PMID 11750127
  4. Regulation of Stearoyl-Coenzyme A Desaturase 1 by trans-10, cis-12 Conjugated Linoleic Acid via SREBP1 in Primary Goat Mammary Epithelial Cells. Zhang T, et al. J Agric Food Chem, 2019 Feb 6. PMID 30644742
  5. SCD1 Alters Long-Chain Fatty Acid (LCFA) Composition and Its Expression Is Directly Regulated by SREBP-1 and PPARγ 1 in Dairy Goat Mammary Cells. Yao D, et al. J Cell Physiol, 2017 Mar. PMID 27341271

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Trans-10, cis-12 Conjugated linoleic acid causes an inhibition of fatty acid synthesis and desaturation and regulates SCD1 expression by affecting the binding of SREBP1 protein to the SRE and NF-Y sites.
    Title: Regulation of Stearoyl-Coenzyme A Desaturase 1 by trans-10, cis-12 Conjugated Linoleic Acid via SREBP1 in Primary Goat Mammary Epithelial Cells.
  2. The contents of triacylglycerol and cholesterol and the desaturase index were significantly decreased as a consequence of SCD1 knockout.
    Title: CRISPR/Cas9-mediated Stearoyl-CoA Desaturase 1 (SCD1) Deficiency Affects Fatty Acid Metabolism in Goat Mammary Epithelial Cells.
  3. SCD1 could markedly affect the fatty acid composition and rate of triacylglycerol synthesis through direct regulation via SREBP-1 and PPARG1.
    Title: SCD1 Alters Long-Chain Fatty Acid (LCFA) Composition and Its Expression Is Directly Regulated by SREBP-1 and PPARγ 1 in Dairy Goat Mammary Cells.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables palmitoyl-CoA 9-desaturase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables stearoyl-CoA 9-desaturase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in response to fatty acid IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in unsaturated fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
stearoyl-CoA desaturase
Names
Acyl-CoA desaturase
Delta(9)-desaturase
Fatty acid desaturase
delta-9 desaturase
stearoyl coenzyme A desaturase
NP_001272548.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285619.1 → NP_001272548.1  stearoyl-CoA desaturase

    See identical proteins and their annotated locations for NP_001272548.1

    Status: PROVISIONAL

    Source sequence(s)
    GU947654
    UniProtKB/Swiss-Prot
    Q95MI7
    UniProtKB/TrEMBL
    Q9BG81
    Related
    ENSCHIP00000038946.1, ENSCHIT00000061286.1
    Conserved Domains (2) summary
    cd03505
    Location:97 → 337
    Delta9-FADS-like; The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide ...
    pfam00487
    Location:101 → 306
    FA_desaturase; Fatty acid desaturase

RefSeqs of Annotated Genomes: Capra hircus Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM170441v1 Primary Assembly

Genomic

  1. NC_030833.1 Reference ASM170441v1 Primary Assembly

    Range
    30404780..30415917 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95MI7.1 GenPept UniProtKB/Swiss-Prot:Q95MI7

Gene LinkOut

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