U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

THPO thrombopoietin [ Canis lupus familiaris (dog) ]

Gene ID: 100855822, updated on 17-Aug-2024

Summary

Go to the top of the page Help
Official Symbol
THPOprovided by VGNC
Official Full Name
thrombopoietinprovided by VGNC
Primary source
VGNC:VGNC:54263
See related
Ensembl:ENSCAFG00845028504
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
ML; TPO; MGDF
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See THPO in Genome Data Viewer
Location:
chromosome: 34
Exon count:
7
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 34 NC_051838.1 (17152310..17162724, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 34 NC_006616.4 (21330370..21340784, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 34 NC_049255.1 (17414218..17424632, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 34 NC_049294.1 (17189183..17199597, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 34 NC_049775.1 (17185251..17195665, complement)

Chromosome 34 - NC_051838.1Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4 gamma 1 Neighboring gene small nucleolar RNA SNORD66 Neighboring gene family with sequence similarity 131 member A Neighboring gene chloride voltage-gated channel 2 Neighboring gene RNA polymerase II, I and III subunit H Neighboring gene chordin Neighboring gene uncharacterized LOC111093864

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of hematopoietic stem cell proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in thrombopoietin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
thrombopoietin
Names
C-MPL ligand
Megakaryocyte colony-stimulating factor
Megakaryocyte growth and development factor
thrombopoietin (myeloproliferative leukemia virus oncogene ligand, megakaryocyte growth and development factor)

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051838.1 Reference ROS_Cfam_1.0

    Range
    17152310..17162724 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038445743.1 → XP_038301671.1  thrombopoietin isoform X4

    UniProtKB/TrEMBL
    A0A8C0Z6L0, A0A8I3S6R4
    Related
    ENSCAFP00845039469.1, ENSCAFT00845050342.1
    Conserved Domains (1) summary
    pfam00758
    Location:25 → 159
    EPO_TPO; Erythropoietin/thrombopoietin

  2. XM_038445741.1 → XP_038301669.1  thrombopoietin isoform X2

    UniProtKB/Swiss-Prot
    P42705
    Conserved Domains (1) summary
    pfam00758
    Location:25 → 172
    EPO_TPO; Erythropoietin/thrombopoietin

  3. XM_038445742.1 → XP_038301670.1  thrombopoietin isoform X3

    UniProtKB/Swiss-Prot
    P42705
    Conserved Domains (1) summary
    pfam00758
    Location:15 → 166
    EPO_TPO; Erythropoietin/thrombopoietin

  4. XM_038445740.1 → XP_038301668.1  thrombopoietin isoform X1

    UniProtKB/Swiss-Prot
    P42705
    UniProtKB/TrEMBL
    A0A8I3Q4L0
    Related
    ENSCAFP00845039448.1, ENSCAFT00845050317.1
    Conserved Domains (1) summary
    pfam00758
    Location:25 → 176
    EPO_TPO; Erythropoietin/thrombopoietin

  5. XM_038445739.1 → XP_038301667.1  thrombopoietin isoform X1

    UniProtKB/Swiss-Prot
    P42705
    UniProtKB/TrEMBL
    A0A8I3Q4L0
    Conserved Domains (1) summary
    pfam00758
    Location:25 → 176
    EPO_TPO; Erythropoietin/thrombopoietin

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049294.1 Alternate UMICH_Zoey_3.1

    Range
    17189183..17199597 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038519934.1 → XP_038375862.1  thrombopoietin isoform X4

    Conserved Domains (1) summary
    pfam00758
    Location:25 → 159
    EPO_TPO; Erythropoietin/thrombopoietin

  2. XM_038519932.1 → XP_038375860.1  thrombopoietin isoform X2

  3. XM_038519933.1 → XP_038375861.1  thrombopoietin isoform X3

  4. XM_038519931.1 → XP_038375859.1  thrombopoietin isoform X1

    Conserved Domains (1) summary
    pfam00758
    Location:25 → 176
    EPO_TPO; Erythropoietin/thrombopoietin

  5. XM_038519930.1 → XP_038375858.1  thrombopoietin isoform X1

    Conserved Domains (1) summary
    pfam00758
    Location:25 → 176
    EPO_TPO; Erythropoietin/thrombopoietin

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049775.1 Alternate UNSW_CanFamBas_1.0

    Range
    17185251..17195665 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038647976.1 → XP_038503904.1  thrombopoietin isoform X4

    Conserved Domains (1) summary
    pfam00758
    Location:25 → 159
    EPO_TPO; Erythropoietin/thrombopoietin

  2. XM_038647974.1 → XP_038503902.1  thrombopoietin isoform X2

  3. XM_038647975.1 → XP_038503903.1  thrombopoietin isoform X3

  4. XM_038647973.1 → XP_038503901.1  thrombopoietin isoform X1

    Conserved Domains (1) summary
    pfam00758
    Location:25 → 176
    EPO_TPO; Erythropoietin/thrombopoietin

  5. XM_038647972.1 → XP_038503900.1  thrombopoietin isoform X1

    Conserved Domains (1) summary
    pfam00758
    Location:25 → 176
    EPO_TPO; Erythropoietin/thrombopoietin

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049255.1 Alternate UU_Cfam_GSD_1.0

    Range
    17414218..17424632 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038583570.1 → XP_038439498.1  thrombopoietin isoform X4

    UniProtKB/TrEMBL
    A0A8C0Z6L0, A0A8I3S6R4
    Conserved Domains (1) summary
    pfam00758
    Location:25 → 159
    EPO_TPO; Erythropoietin/thrombopoietin

  2. XM_038583568.1 → XP_038439496.1  thrombopoietin isoform X2

    UniProtKB/Swiss-Prot
    P42705

  3. XM_038583569.1 → XP_038439497.1  thrombopoietin isoform X3

    UniProtKB/Swiss-Prot
    P42705

  4. XM_038583567.1 → XP_038439495.1  thrombopoietin isoform X1

    UniProtKB/Swiss-Prot
    P42705
    UniProtKB/TrEMBL
    A0A8C0JPL2, A0A8C0Z6K8
    Conserved Domains (1) summary
    pfam00758
    Location:25 → 176
    EPO_TPO; Erythropoietin/thrombopoietin

  5. XM_038583566.1 → XP_038439494.1  thrombopoietin isoform X1

    UniProtKB/Swiss-Prot
    P42705
    UniProtKB/TrEMBL
    A0A8C0JPL2, A0A8C0Z6K8
    Conserved Domains (1) summary
    pfam00758
    Location:25 → 176
    EPO_TPO; Erythropoietin/thrombopoietin

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006616.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    21330370..21340784 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038462872.1 → XP_038318800.1  thrombopoietin isoform X4

    UniProtKB/TrEMBL
    A0A8C0Z6L0, A0A8I3S6R4
    Conserved Domains (1) summary
    pfam00758
    Location:25 → 159
    EPO_TPO; Erythropoietin/thrombopoietin

  2. XM_022414175.2 → XP_022269883.1  thrombopoietin isoform X2

    UniProtKB/Swiss-Prot
    P42705
    Conserved Domains (1) summary
    pfam00758
    Location:25 → 172
    EPO_TPO; Erythropoietin/thrombopoietin

  3. XM_014110447.3 → XP_013965922.1  thrombopoietin isoform X3

    UniProtKB/Swiss-Prot
    P42705
    Conserved Domains (1) summary
    pfam00758
    Location:15 → 166
    EPO_TPO; Erythropoietin/thrombopoietin

  4. XM_038462871.1 → XP_038318799.1  thrombopoietin isoform X1

    UniProtKB/Swiss-Prot
    P42705
    UniProtKB/TrEMBL
    A0A8C0JPL2, A0A8C0Z6K8
    Conserved Domains (1) summary
    pfam00758
    Location:25 → 176
    EPO_TPO; Erythropoietin/thrombopoietin

  5. XM_005639779.4 → XP_005639836.1  thrombopoietin isoform X1

    See identical proteins and their annotated locations for XP_005639836.1

    UniProtKB/Swiss-Prot
    P42705
    UniProtKB/TrEMBL
    A0A8C0JPL2, A0A8C0Z6K8
    Conserved Domains (1) summary
    pfam00758
    Location:25 → 176
    EPO_TPO; Erythropoietin/thrombopoietin
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P42705.1 GenPept UniProtKB/Swiss-Prot:P42705

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.