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CDK2 cyclin dependent kinase 2 [ Canis lupus familiaris (dog) ]

Gene ID: 100855704, updated on 17-Aug-2024

Summary

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Official Symbol
CDK2provided by VGNC
Official Full Name
cyclin dependent kinase 2provided by VGNC
Primary source
VGNC:VGNC:39051
See related
Ensembl:ENSCAFG00845005902
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See CDK2 in Genome Data Viewer
Location:
chromosome: 10
Exon count:
10
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 10 NC_051814.1 (307657..313366)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 10 NC_006592.4 (362779..368479)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 10 NC_049231.1 (652514..658220)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 10 NC_049270.1 (285465..291170)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 10 NC_049751.1 (528243..533942)

Chromosome 10 - NC_051814.1Genomic Context describing neighboring genes Neighboring gene PYM homolog 1, exon junction complex associated factor Neighboring gene diacylglycerol kinase alpha Neighboring gene premelanosome protein Neighboring gene RAB5B, member RAS oncogene family Neighboring gene sulfite oxidase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cyclin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of G2/M transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of cyclin-dependent protein kinase holoenzyme complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
cyclin-dependent kinase 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051814.1 Reference ROS_Cfam_1.0

    Range
    307657..313366
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038678950.1 → XP_038534878.1  cyclin-dependent kinase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0NEG2, A0A8I3N128
    Related
    ENSCAFP00845008144.1, ENSCAFT00845010477.1
    Conserved Domains (1) summary
    cd07860
    Location:3 → 334
    STKc_CDK2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3

  2. XM_038678952.1 → XP_038534880.1  cyclin-dependent kinase 2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0NMM0, A0A8I3MY98
    Related
    ENSCAFP00845008149.1, ENSCAFT00845010482.1
    Conserved Domains (1) summary
    cd07860
    Location:3 → 286
    STKc_CDK2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3

  3. XM_038678953.1 → XP_038534881.1  cyclin-dependent kinase 2 isoform X4

    Conserved Domains (1) summary
    cl21453
    Location:1 → 244
    PKc_like; Protein Kinases, catalytic domain

  4. XM_038678951.1 → XP_038534879.1  cyclin-dependent kinase 2 isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:4 → 299
    PKc_like; Protein Kinases, catalytic domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049270.1 Alternate UMICH_Zoey_3.1

    Range
    285465..291170
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038487727.1 → XP_038343655.1  cyclin-dependent kinase 2 isoform X1

    Conserved Domains (1) summary
    cd07860
    Location:3 → 334
    STKc_CDK2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3

  2. XM_038487729.1 → XP_038343657.1  cyclin-dependent kinase 2 isoform X3

    Conserved Domains (1) summary
    cd07860
    Location:3 → 286
    STKc_CDK2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3

  3. XM_038487730.1 → XP_038343658.1  cyclin-dependent kinase 2 isoform X4

    Conserved Domains (1) summary
    cl21453
    Location:1 → 244
    PKc_like; Protein Kinases, catalytic domain

  4. XM_038487728.1 → XP_038343656.1  cyclin-dependent kinase 2 isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:4 → 299
    PKc_like; Protein Kinases, catalytic domain

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049751.1 Alternate UNSW_CanFamBas_1.0

    Range
    528243..533942
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038613586.1 → XP_038469514.1  cyclin-dependent kinase 2 isoform X1

    Conserved Domains (1) summary
    cd07860
    Location:3 → 334
    STKc_CDK2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3

  2. XM_038613588.1 → XP_038469516.1  cyclin-dependent kinase 2 isoform X3

    Conserved Domains (1) summary
    cd07860
    Location:3 → 286
    STKc_CDK2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3

  3. XM_038613589.1 → XP_038469517.1  cyclin-dependent kinase 2 isoform X4

    Conserved Domains (1) summary
    cl21453
    Location:1 → 244
    PKc_like; Protein Kinases, catalytic domain

  4. XM_038613587.1 → XP_038469515.1  cyclin-dependent kinase 2 isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:4 → 299
    PKc_like; Protein Kinases, catalytic domain

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049231.1 Alternate UU_Cfam_GSD_1.0

    Range
    652514..658220
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038549615.1 → XP_038405543.1  cyclin-dependent kinase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0NEG2, A0A8I3N128
    Conserved Domains (1) summary
    cd07860
    Location:3 → 334
    STKc_CDK2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3

  2. XM_038549617.1 → XP_038405545.1  cyclin-dependent kinase 2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0NMM0, A0A8I3MY98
    Conserved Domains (1) summary
    cd07860
    Location:3 → 286
    STKc_CDK2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3

  3. XM_038549618.1 → XP_038405546.1  cyclin-dependent kinase 2 isoform X4

    Conserved Domains (1) summary
    cl21453
    Location:1 → 244
    PKc_like; Protein Kinases, catalytic domain

  4. XM_038549616.1 → XP_038405544.1  cyclin-dependent kinase 2 isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:4 → 299
    PKc_like; Protein Kinases, catalytic domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006592.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    362779..368479
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005625479.4 → XP_005625536.1  cyclin-dependent kinase 2 isoform X1

    See identical proteins and their annotated locations for XP_005625536.1

    UniProtKB/TrEMBL
    A0A8C0NEG2, A0A8I3N128
    Conserved Domains (1) summary
    cd07860
    Location:3 → 334
    STKc_CDK2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3

  2. XM_003639320.5 → XP_003639368.1  cyclin-dependent kinase 2 isoform X3

    See identical proteins and their annotated locations for XP_003639368.1

    UniProtKB/TrEMBL
    A0A8C0NMM0, A0A8I3MY98
    Conserved Domains (1) summary
    cd07860
    Location:3 → 286
    STKc_CDK2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3

  3. XM_022424033.2 → XP_022279741.1  cyclin-dependent kinase 2 isoform X4

    Conserved Domains (1) summary
    cl21453
    Location:1 → 244
    PKc_like; Protein Kinases, catalytic domain

  4. XM_022424031.2 → XP_022279739.1  cyclin-dependent kinase 2 isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:4 → 299
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
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