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Tbc1d14 TBC1 domain family, member 14 [ Mus musculus (house mouse) ]

Gene ID: 100855, updated on 2-Nov-2024

Summary

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Official Symbol
Tbc1d14provided by MGI
Official Full Name
TBC1 domain family, member 14provided by MGI
Primary source
MGI:MGI:1098708
See related
Ensembl:ENSMUSG00000029192 AllianceGenome:MGI:1098708
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1322; D5Ertd110e; 2810413P16Rik
Summary
Predicted to enable GTPase activator activity and protein kinase binding activity. Predicted to be involved in negative regulation of autophagy; recycling endosome to Golgi transport; and regulation of autophagosome assembly. Predicted to be located in Golgi apparatus and nucleoplasm. Predicted to be active in autophagosome and recycling endosome. Is expressed in cortical plate and metanephros. Orthologous to human TBC1D14 (TBC1 domain family member 14). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E18 (RPKM 21.3), testis adult (RPKM 18.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tbc1d14 in Genome Data Viewer
Location:
5 B3; 5 19.15 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (36647948..36743611, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (36490604..36586271, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene GrpE-like 1, mitochondrial Neighboring gene STARR-positive B cell enhancer ABC_E3572 Neighboring gene transcriptional adaptor 2B Neighboring gene coiled-coil domain containing 96 Neighboring gene predicted gene, 32528 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:36872352-36872539 Neighboring gene STARR-positive B cell enhancer ABC_E6323 Neighboring gene STARR-positive B cell enhancer ABC_E10317 Neighboring gene STARR-positive B cell enhancer ABC_E4753 Neighboring gene DNA segment, Chr 5, ERATO Doi 579, expressed Neighboring gene predicted gene, 32584 Neighboring gene predicted gene, 24878

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CLICK: one-step generation of conditional knockout mice. Miyasaka Y, et al. BMC Genomics, 2018 May 2. PMID 29720086, Free PMC Article
  2. High resolution mapping and positional cloning of ENU-induced mutations in the Rw region of mouse chromosome 5. Ching YH, et al. BMC Genet, 2010 Nov 30. PMID 21118569, Free PMC Article
  3. Random mutagenesis of proximal mouse chromosome 5 uncovers predominantly embryonic lethal mutations. Wilson L, et al. Genome Res, 2005 Aug. PMID 16024820, Free PMC Article
  4. Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2002 Oct 31. PMID 12465718
  5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC102624

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of autophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in recycling endosome to Golgi transport ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of autophagosome assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in autophagosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in autophagosome ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in recycling endosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
TBC1 domain family member 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113362.1 → NP_001106833.1  TBC1 domain family member 14 isoform a

    See identical proteins and their annotated locations for NP_001106833.1

    Status: VALIDATED

    Source sequence(s)
    AK029986, BC086316, BC096446
    Consensus CDS
    CCDS51480.1
    UniProtKB/Swiss-Prot
    Q3V2L6, Q4VAC6, Q8CGA2, Q8CHA5
    UniProtKB/TrEMBL
    G3UVU5
    Related
    ENSMUSP00000116519.2, ENSMUST00000130417.8
    Conserved Domains (2) summary
    smart00164
    Location:419 → 651
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    pfam15346
    Location:350 → 392
    ARGLU; Arginine and glutamate-rich 1

  2. NM_001113364.1 → NP_001106835.1  TBC1 domain family member 14 isoform c

    See identical proteins and their annotated locations for NP_001106835.1

    Status: VALIDATED

    Source sequence(s)
    AB064521, BC086316, BC096446, BQ745653
    Consensus CDS
    CCDS51479.1
    UniProtKB/TrEMBL
    E9PYB1, Q76LY3
    Related
    ENSMUSP00000131876.2, ENSMUST00000171385.8
    Conserved Domains (2) summary
    smart00164
    Location:118 → 350
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    pfam17664
    Location:9 → 88
    DUF5526; Family of unknown function (DUF5526)

  3. NM_133910.3 → NP_598671.3  TBC1 domain family member 14 isoform b

    See identical proteins and their annotated locations for NP_598671.3

    Status: VALIDATED

    Source sequence(s)
    BC086316, BC096446, BQ769916
    Consensus CDS
    CCDS19240.2
    UniProtKB/Swiss-Prot
    Q3V2L6, Q4VAC6, Q8CGA2, Q8CHA5
    UniProtKB/TrEMBL
    E9Q8K4
    Related
    ENSMUSP00000031094.9, ENSMUST00000031094.15
    Conserved Domains (2) summary
    smart00164
    Location:399 → 631
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    pfam15346
    Location:330 → 369
    ARGLU; Arginine and glutamate-rich 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    36647948..36743611 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503645.1 → XP_006503708.1  TBC1 domain family member 14 isoform X5

    See identical proteins and their annotated locations for XP_006503708.1

    UniProtKB/TrEMBL
    E9PYB1, Q76LY3
    Related
    ENSMUSP00000114508.2, ENSMUST00000126077.8
    Conserved Domains (2) summary
    smart00164
    Location:118 → 350
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    pfam17664
    Location:9 → 88
    DUF5526; Family of unknown function (DUF5526)

  2. XM_006503640.4 → XP_006503703.1  TBC1 domain family member 14 isoform X1

    See identical proteins and their annotated locations for XP_006503703.1

    UniProtKB/Swiss-Prot
    Q3V2L6, Q4VAC6, Q8CGA2, Q8CHA5
    UniProtKB/TrEMBL
    G3UVU5
    Related
    ENSMUSP00000117414.2, ENSMUST00000124036.8
    Conserved Domains (2) summary
    smart00164
    Location:419 → 651
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    pfam15346
    Location:350 → 392
    ARGLU; Arginine and glutamate-rich 1

  3. XM_006503641.5 → XP_006503704.1  TBC1 domain family member 14 isoform X3

    See identical proteins and their annotated locations for XP_006503704.1

    UniProtKB/Swiss-Prot
    Q3V2L6, Q4VAC6, Q8CGA2, Q8CHA5
    UniProtKB/TrEMBL
    E9Q8K4
    Related
    ENSMUSP00000121516.2, ENSMUST00000140607.8
    Conserved Domains (2) summary
    smart00164
    Location:399 → 631
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    pfam15346
    Location:330 → 369
    ARGLU; Arginine and glutamate-rich 1

  4. XM_036164700.1 → XP_036020593.1  TBC1 domain family member 14 isoform X3

    UniProtKB/Swiss-Prot
    Q3V2L6, Q4VAC6, Q8CGA2, Q8CHA5
    UniProtKB/TrEMBL
    E9Q8K4
    Conserved Domains (2) summary
    smart00164
    Location:399 → 631
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    pfam15346
    Location:330 → 369
    ARGLU; Arginine and glutamate-rich 1

  5. XM_006503642.5 → XP_006503705.1  TBC1 domain family member 14 isoform X3

    See identical proteins and their annotated locations for XP_006503705.1

    UniProtKB/Swiss-Prot
    Q3V2L6, Q4VAC6, Q8CGA2, Q8CHA5
    UniProtKB/TrEMBL
    E9Q8K4
    Conserved Domains (2) summary
    smart00164
    Location:399 → 631
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    pfam15346
    Location:330 → 369
    ARGLU; Arginine and glutamate-rich 1

  6. XM_036164699.1 → XP_036020592.1  TBC1 domain family member 14 isoform X2

    UniProtKB/Swiss-Prot
    Q3V2L6, Q4VAC6, Q8CGA2, Q8CHA5
    Related
    ENSMUSP00000115467.2, ENSMUST00000136189.8
    Conserved Domains (1) summary
    smart00164
    Location:399 → 607
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  7. XM_036164703.1 → XP_036020596.1  TBC1 domain family member 14 isoform X7

    UniProtKB/TrEMBL
    Q76LY3, Q921M0
    Conserved Domains (1) summary
    smart00164
    Location:58 → 290
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  8. XM_006503644.5 → XP_006503707.1  TBC1 domain family member 14 isoform X4

    See identical proteins and their annotated locations for XP_006503707.1

    UniProtKB/TrEMBL
    Q76LY3
    Conserved Domains (1) summary
    smart00164
    Location:169 → 401
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  9. XM_036164702.1 → XP_036020595.1  TBC1 domain family member 14 isoform X6

    UniProtKB/TrEMBL
    Q76LY3
    Conserved Domains (1) summary
    smart00164
    Location:118 → 326
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  10. XM_036164704.1 → XP_036020597.1  TBC1 domain family member 14 isoform X7

    UniProtKB/TrEMBL
    Q76LY3, Q921M0
    Conserved Domains (1) summary
    smart00164
    Location:58 → 290
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  11. XM_006503647.5 → XP_006503710.1  TBC1 domain family member 14 isoform X7

    See identical proteins and their annotated locations for XP_006503710.1

    UniProtKB/TrEMBL
    Q76LY3, Q921M0
    Conserved Domains (1) summary
    smart00164
    Location:58 → 290
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

RNA

  1. XR_004942417.1 RNA Sequence

  2. XR_376793.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CGA2.2 GenPept UniProtKB/Swiss-Prot:Q8CGA2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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