MIR5100 microRNA 5100 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MIR5100provided by HGNC
Official Full Name: microRNA 5100provided by HGNC
Primary source: HGNC:HGNC:43540
See related: Ensembl:ENSG00000263795 miRBase:MI0019116; AllianceGenome:HGNC:43540
Gene type: ncRNA
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

Location:: 10q11.21

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (42997563..42997681)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (43875032..43875150)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (43493011..43493129)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MicroRNA expression profiling in acute kidney injury.
Title: MicroRNA expression profiling in acute kidney injury.
Long Non-Coding LEF1-AS1 Sponge miR-5100 Regulates Apoptosis and Autophagy in Gastric Cancer Cells via the miR-5100/DEK/AMPK-mTOR Axis.
Title: Long Non-Coding LEF1-AS1 Sponge miR-5100 Regulates Apoptosis and Autophagy in Gastric Cancer Cells via the miR-5100/DEK/AMPK-mTOR Axis.
MKL1/miR-5100/CAAP1 loop regulates autophagy and apoptosis in gastric cancer cells.
Title: MKL1/miR-5100/CAAP1 loop regulates autophagy and apoptosis in gastric cancer cells.
mir-5100 expression was higher in patients with SLE compared to controls, in patients with SLE compared to patients with rheumatoid arthritis, and in patients with active SLE compared to inactive SLE.
Title: Serum miRNA-371b-5p and miRNA-5100 act as biomarkers for systemic lupus erythematosus.
High miR5100 expression is associated with metastasis of lung cancer.
Title: Hypoxic BMSC-derived exosomal miRNAs promote metastasis of lung cancer cells via STAT3-induced EMT.
The expression levels of let-7f-5p, miR-5100 and miR-25-3p were significantly associated with the incidence rate of cALL, and these miRNAs might serve as promising biomarkers for cALL[Precursor Cell Lymphoblastic Leukemia-Lymphoma].
Title: [Association between expression of plasma miRNA and the risk of childhood acute lymphocytic leukemia].
These results suggest that miR-5100 increases the cisplatin resistance of the lung cancer stem cells by inhibiting the Rab6.
Title: MiR-5100 increases the cisplatin resistance of the lung cancer stem cells by inhibiting the Rab6.
Multivariate survival analysis verified that miR-5100 expression level was an independent predictor of both overall survival and progression-free survival for non-small-cell lung cancer patients
Title: Increasing expression of miR-5100 in non-small-cell lung cancer and correlation with prognosis.
Results identify an anti-metastatic miRNA, miR-5100, that decreases the metastatic ability of pancreatic cancer partially by suppressing expression of PODXL.
Title: Overexpression of microRNA-5100 decreases the aggressive phenotype of pancreatic cancer cells by targeting PODXL.
Data suggest that miR-5100 promotes tumor growth by facilitating the G1/S transition and targeting Rab6.
Title: miR-5100 promotes tumor growth in lung cancer by targeting Rab6.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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General gene information

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NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.