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Tph2 tryptophan hydroxylase 2 [ Cricetulus griseus (Chinese hamster) ]

Gene ID: 100763947, updated on 8-Mar-2024

Summary

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Gene symbol
Tph2
Gene description
tryptophan hydroxylase 2
Locus tag
I79_005262
See related
Ensembl:ENSCGRG00015009077
Gene type
protein coding
RefSeq status
MODEL
Organism
Cricetulus griseus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Cricetinae; Cricetulus
Orthologs
human mouse all
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Genomic context

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See Tph2 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
11
Annotation release Status Assembly Chr Location
104 current CriGri_1.0 (GCF_000223135.1) Unplaced Scaffold NW_003613724.1 (1348584..1452255, complement)
104 current CriGri-PICRH-1.0 (GCF_003668045.3) 1 Unlocalized Scaffold NW_023276806.1 (140931389..141034299)

NW_003613724.1Genomic Context describing neighboring genes Neighboring gene transfer RNA valine (anticodon AAC) Neighboring gene thyrotropin releasing hormone degrading enzyme Neighboring gene TBC1 domain family member 15 Neighboring gene RAB21, member RAS oncogene family

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables tryptophan 5-monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in aromatic amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in serotonin biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tryptophan 5-hydroxylase 2
Names
Tryptophan 5-hydroxylase 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Cricetulus griseus Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference CriGri_1.0 Primary Assembly

Genomic

  1. NW_003613724.1 Reference CriGri_1.0 Primary Assembly

    Range
    1348584..1452255 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_007639857.4 → XP_007638047.1  tryptophan 5-hydroxylase 2 isoform X1

    UniProtKB/TrEMBL
    A0A9J7J9A4, G3H4Q5
    Conserved Domains (3) summary
    TIGR01270
    Location:68 → 491
    Trp_5_monoox; tryptophan 5-monooxygenase, tetrameric
    cd04929
    Location:70 → 143
    ACT_TPH; ACT domain of the nonheme iron-dependent aromatic amino acid hydroxylase, tryptophan hydroxylases (TPH), both peripheral (TPH1) and neuronal (TPH2) enzymes
    pfam00351
    Location:159 → 488
    Biopterin_H; Biopterin-dependent aromatic amino acid hydroxylase

  2. XM_035452069.1 → XP_035307960.1  tryptophan 5-hydroxylase 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C2M0Q8, G3H4Q5
    Conserved Domains (2) summary
    cd04929
    Location:64 → 137
    ACT_TPH; ACT domain of the nonheme iron-dependent aromatic amino acid hydroxylase, tryptophan hydroxylases (TPH), both peripheral (TPH1) and neuronal (TPH2) enzymes
    pfam00351
    Location:153 → 482
    Biopterin_H; Biopterin-dependent aromatic amino acid hydroxylase

Alternate CriGri-PICRH-1.0

Genomic

  1. NW_023276806.1 Alternate CriGri-PICRH-1.0

    Range
    140931389..141034299
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_035451292.1 → XP_035307183.1  tryptophan 5-hydroxylase 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C2M0Q8, G3H4Q5
    Related
    ENSCGRP00015011826.1, ENSCGRT00015014484.2
    Conserved Domains (2) summary
    cd04929
    Location:64 → 137
    ACT_TPH; ACT domain of the nonheme iron-dependent aromatic amino acid hydroxylase, tryptophan hydroxylases (TPH), both peripheral (TPH1) and neuronal (TPH2) enzymes
    pfam00351
    Location:153 → 482
    Biopterin_H; Biopterin-dependent aromatic amino acid hydroxylase

  2. XM_027392395.2 → XP_027248196.1  tryptophan 5-hydroxylase 2 isoform X1

    UniProtKB/TrEMBL
    A0A9J7J9A4, G3H4Q5
Nucleotide Protein Strain
Heading Accession and Version

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