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Capn3 calpain 3 [ Cricetulus griseus (Chinese hamster) ]

Gene ID: 100758723, updated on 8-Mar-2024

Summary

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Gene symbol
Capn3
Gene description
calpain 3
See related
Ensembl:ENSCGRG00015021584
Gene type
protein coding
RefSeq status
MODEL
Organism
Cricetulus griseus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Cricetinae; Cricetulus
Orthologs
human mouse all
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Genomic context

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See Capn3 in Genome Data Viewer
Location:
chromosome: 6
Exon count:
25
Annotation release Status Assembly Chr Location
104 current CriGri_1.0 (GCF_000223135.1) Unplaced Scaffold NW_003613677.1 (1857282..1909931, complement)
104 current CriGri-PICRH-1.0 (GCF_003668045.3) 6 NC_048599.1 (57972483..58025441, complement)

NW_003613677.1Genomic Context describing neighboring genes Neighboring gene synaptosome associated protein 23 Neighboring gene zinc finger protein 106 Neighboring gene COMM domain-containing protein 7-like Neighboring gene glucosidase alpha, neutral C Neighboring gene transmembrane protein 87A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium-dependent cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
calpain-3
Names
calpain 3, (p94)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Cricetulus griseus Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference CriGri_1.0 Primary Assembly

Genomic

  1. NW_003613677.1 Reference CriGri_1.0 Primary Assembly

    Range
    1857282..1909931 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_035444559.1 → XP_035300450.1  calpain-3 isoform X4

    UniProtKB/TrEMBL
    A0A8C2QPR8, A0A9J7JZL8
    Conserved Domains (3) summary
    cd16190
    Location:561 → 729
    EFh_PEF_CAPN3; Calcium-activated neutral
    pfam00648
    Location:77 → 367
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:388 → 526
    Calpain_III; Calpain large subunit, domain III

  2. XM_035444555.1 → XP_035300446.1  calpain-3 isoform X2

    UniProtKB/TrEMBL
    A0A8C2QPR8, A0A9J7K712
    Conserved Domains (4) summary
    cd16190
    Location:647 → 815
    EFh_PEF_CAPN3; Calcium-activated neutral
    pfam00648
    Location:77 → 415
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:436 → 574
    Calpain_III; Calpain large subunit, domain III
    pfam16648
    Location:583 → 647
    Calpain_u2; Unstructured region on Calpain-3

  3. XM_003498051.5 → XP_003498099.1  calpain-3 isoform X1

    See identical proteins and their annotated locations for XP_003498099.1

    UniProtKB/TrEMBL
    A0A8C2N2E9, A0A9J7JVP3
    Conserved Domains (6) summary
    cd00051
    Location:697 → 751
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00648
    Location:77 → 415
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:429 → 579
    Calpain_III; Calpain large subunit, domain III
    pfam13499
    Location:728 → 784
    EF-hand_7; EF-hand domain pair
    pfam16648
    Location:583 → 653
    Calpain_u2; Unstructured region on Calpain-3
    cl08302
    Location:728 → 817
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  4. XM_003498050.5 → XP_003498098.1  calpain-3 isoform X5

    See identical proteins and their annotated locations for XP_003498098.1

    UniProtKB/TrEMBL
    A0A8C2N3P1, A0A9J7GAK1
    Conserved Domains (5) summary
    cd00051
    Location:585 → 639
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00648
    Location:51 → 347
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:361 → 511
    Calpain_III; Calpain large subunit, domain III
    pfam13499
    Location:616 → 672
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:616 → 705
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  5. XM_035444558.1 → XP_035300449.1  calpain-3 isoform X3

    UniProtKB/TrEMBL
    A0A8C2N5T1, A0A9J7H2E0
    Conserved Domains (3) summary
    cd16190
    Location:589 → 757
    EFh_PEF_CAPN3; Calcium-activated neutral
    pfam00648
    Location:51 → 395
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:416 → 554
    Calpain_III; Calpain large subunit, domain III

Alternate CriGri-PICRH-1.0

Genomic

  1. NC_048599.1 Alternate CriGri-PICRH-1.0

    Range
    57972483..58025441 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_035446517.1 → XP_035302408.1  calpain-3 isoform X4

    UniProtKB/TrEMBL
    A0A8C2QPR8, A0A9J7JZL8
    Conserved Domains (3) summary
    cd16190
    Location:561 → 729
    EFh_PEF_CAPN3; Calcium-activated neutral
    pfam00648
    Location:77 → 367
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:388 → 526
    Calpain_III; Calpain large subunit, domain III

  2. XM_035446515.1 → XP_035302406.1  calpain-3 isoform X2

    UniProtKB/TrEMBL
    A0A8C2QPR8, A0A9J7K712
    Conserved Domains (4) summary
    cd16190
    Location:647 → 815
    EFh_PEF_CAPN3; Calcium-activated neutral
    pfam00648
    Location:77 → 415
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:436 → 574
    Calpain_III; Calpain large subunit, domain III
    pfam16648
    Location:583 → 647
    Calpain_u2; Unstructured region on Calpain-3

  3. XM_027422116.2 → XP_027277917.1  calpain-3 isoform X1

    UniProtKB/TrEMBL
    A0A8C2N2E9, A0A9J7JVP3
    Related
    ENSCGRP00015029343.1, ENSCGRT00015035892.2

  4. XM_027422114.2 → XP_027277915.1  calpain-3 isoform X5

    UniProtKB/TrEMBL
    A0A8C2N3P1, A0A9J7GAK1

  5. XM_035446516.1 → XP_035302407.1  calpain-3 isoform X3

    UniProtKB/TrEMBL
    A0A8C2N5T1, A0A9J7H2E0
    Related
    ENSCGRP00015029365.1, ENSCGRT00015035924.2
    Conserved Domains (3) summary
    cd16190
    Location:589 → 757
    EFh_PEF_CAPN3; Calcium-activated neutral
    pfam00648
    Location:51 → 395
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:416 → 554
    Calpain_III; Calpain large subunit, domain III
Nucleotide Protein Strain
Heading Accession and Version

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