HIF1A-AS2 HIF1A antisense RNA 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: HIF1A-AS2provided by HGNC
Official Full Name: HIF1A antisense RNA 2provided by HGNC
Primary source: HGNC:HGNC:43015
See related: MIM:614529; AllianceGenome:HGNC:43015
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: aHIF; 3'aHIF-1A
Summary: Enables miRNA inhibitor activity via base-pairing. Involved in lncRNA-mediated post-transcriptional gene silencing and positive regulation of miRNA catabolic process. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: 14q23.2

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	14	NC_000014.9 (61747039..61749089, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	14	NC_060938.1 (55953606..55955657, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	14	NC_000014.8 (62213757..62215807, complement)

Chromosome 14 - NC_000014.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LncRNA HIF1A-AS2 modulated by HPV16 E6 regulates apoptosis of cervical cancer cells via P53/caspase9/caspase3 axis.
Title: LncRNA HIF1A-AS2 modulated by HPV16 E6 regulates apoptosis of cervical cancer cells via P53/caspase9/caspase3 axis.
The evolving role of long noncoding RNA HIF1A-AS2 in diabetic retinopathy: a cross-link axis between hypoxia, oxidative stress and angiogenesis via MAPK/VEGF-dependent pathway.
Title: The evolving role of long noncoding RNA HIF1A-AS2 in diabetic retinopathy: a cross-link axis between hypoxia, oxidative stress and angiogenesis via MAPK/VEGF-dependent pathway.
Knockdown of lncRNA HIF1A-AS2 increases drug sensitivity of SCLC cells in association with autophagy.
Title: Knockdown of lncRNA HIF1A-AS2 increases drug sensitivity of SCLC cells in association with autophagy.
Long noncoding RNA HIF1A-AS2 facilitates cell survival and migration by sponging miR-33b-5p to modulate SIRT6 expression in osteosarcoma.
Title: Long noncoding RNA HIF1A-AS2 facilitates cell survival and migration by sponging miR-33b-5p to modulate SIRT6 expression in osteosarcoma.
LncRNA HIF1A-AS2 promotes osteosarcoma progression by acting as a sponge of miR-129-5p.
Title: LncRNA HIF1A-AS2 promotes osteosarcoma progression by acting as a sponge of miR-129-5p.
High expression of HIF1A-AS2 was associated with lymph node metastasis, distant metastasis and unfavorable histological grade in the triple-negative breast cancer patients.HIF1A-AS2 high expression acted as an independent poor prognostic factor for overall survival in the triple-negative breast cancer patients.
Title: HIF1A-AS2 predicts poor prognosis and regulates cell migration and invasion in triple-negative breast cancer.
KCNQ1OT1, HIF1A-AS2 and APOA1-AS are promising novel biomarkers for diagnosis of coronary artery disease
Title: KCNQ1OT1, HIF1A-AS2 and APOA1-AS are promising novel biomarkers for diagnosis of coronary artery disease.
This study suggests that upregulated HIF1A-AS2 hampers the p53 family proteins dependent apoptotic pathway to promote Cisplatin resistance in bladder cancer. These results suggested that HIF1A-AS2 plays oncogenic roles and can be used as a therapeutic target for treating human bladder cancer.
Title: The long noncoding RNA HIF1A-AS2 facilitates cisplatin resistance in bladder cancer.
Results identified AHIF was significantly upregulated in glioblastoma multiforme (GBM) tissues, as well as in radioresistant GBM cells. Also, the study establishes that AHIF promotes GBM progression and radioresistance via exosomes.
Title: AHIF promotes glioblastoma progression and radioresistance via exosomes.
HIF1A-AS2 exerted the oncogenic functions in CRC through regulating miR-129-5p/DNMT3A axis.
Title: LncRNA HIF1A-AS2 positively affects the progression and EMT formation of colorectal cancer through regulating miR-129-5p and DNMT3A.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D14S87E (e-PCR)
- UniSTS:147519

RH70592 (e-PCR)
- UniSTS:32832

SGC35483 (e-PCR)
- UniSTS:72875

D14S87E (e-PCR)
- UniSTS:147452

HIF1A (e-PCR)
- UniSTS:278524

Other Names

HIF1A antisense RNA 2 (non-protein coding)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.