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Map2k5 mitogen-activated protein kinase kinase 5 [ Cavia porcellus (domestic guinea pig) ]

Gene ID: 100732076, updated on 10-Oct-2024

Summary

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Gene symbol
Map2k5
Gene description
mitogen-activated protein kinase kinase 5
See related
Ensembl:ENSCPOG00000000970
Gene type
protein coding
RefSeq status
MODEL
Organism
Cavia porcellus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae; Cavia
Orthologs
human mouse all
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Genomic context

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See Map2k5 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current mCavPor4.1 (GCF_034190915.1) Unplaced Scaffold NW_026947493.1 (1230413..1476661, complement)
103 previous assembly Cavpor3.0 (GCF_000151735.1) Unplaced Scaffold NT_176419.1 (87302690..87548983)

NW_026947493.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134477807 Neighboring gene uncharacterized LOC134477808 Neighboring gene SKI family transcriptional corepressor 1 Neighboring gene U6 spliceosomal RNA Neighboring gene chromosome unknown C15orf61 homolog Neighboring gene IQ motif containing H Neighboring gene uncharacterized LOC134477757

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables MAP kinase kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in MAPK cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
dual specificity mitogen-activated protein kinase kinase 5

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_034190915.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mCavPor4.1

Genomic

  1. NW_026947493.1 Reference mCavPor4.1

    Range
    1230413..1476661 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063257801.1 → XP_063113871.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X1

  2. XM_003480203.5 → XP_003480251.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X9

    UniProtKB/TrEMBL
    H0UV50
    Related
    ENSCPOP00000000870.3
    Conserved Domains (3) summary
    cd06395
    Location:17 → 107
    PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
    cd06619
    Location:164 → 432
    PKc_MKK5; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 5
    smart00220
    Location:170 → 409
    S_TKc; Serine/Threonine protein kinases, catalytic domain

  3. XM_003480202.5 → XP_003480250.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X7

    UniProtKB/TrEMBL
    A0A286Y3X6, H0UV50
    Related
    ENSCPOP00000028952.1
    Conserved Domains (3) summary
    cd06395
    Location:17 → 107
    PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
    cd06619
    Location:164 → 442
    PKc_MKK5; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 5
    smart00220
    Location:170 → 419
    S_TKc; Serine/Threonine protein kinases, catalytic domain

  4. XM_063257804.1 → XP_063113874.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X5

  5. XM_063257806.1 → XP_063113876.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X8

  6. XM_063257812.1 → XP_063113882.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X13

  7. XM_013143898.3 → XP_012999352.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X4

    UniProtKB/TrEMBL
    H0UV50
    Conserved Domains (3) summary
    cd06395
    Location:17 → 107
    PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
    smart00220
    Location:170 → 449
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:164 → 472
    PKc_like; Protein Kinases, catalytic domain

  8. XM_063257802.1 → XP_063113872.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X2

  9. XM_063257805.1 → XP_063113875.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X6

  10. XM_063257808.1 → XP_063113878.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X11

  11. XM_013143897.3 → XP_012999351.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X3

    UniProtKB/TrEMBL
    H0UV50
    Conserved Domains (2) summary
    cd06395
    Location:17 → 107
    PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...
    cd06619
    Location:164 → 482
    PKc_MKK5; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 5

  12. XM_063257809.1 → XP_063113879.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X11

  13. XM_063257811.1 → XP_063113881.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X12

  14. XM_063257807.1 → XP_063113877.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X10

  15. XM_063257813.1 → XP_063113883.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X14

  16. XM_063257814.1 → XP_063113884.1  dual specificity mitogen-activated protein kinase kinase 5 isoform X15

RNA

  1. XR_010050301.1 RNA Sequence

  2. XR_010050302.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version

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