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Gbp6 guanylate binding protein 6 [ Mus musculus (house mouse) ]

Gene ID: 100702, updated on 11-Apr-2024

Summary

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Official Symbol
Gbp6provided by MGI
Official Full Name
guanylate binding protein 6provided by MGI
Primary source
MGI:MGI:2140937
See related
Ensembl:ENSMUSG00000104713 AllianceGenome:MGI:2140937
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GBP-6; Mpa2l
Summary
Predicted to enable GTP binding activity and GTPase activity. Acts upstream of or within several processes, including cellular response to interferon-beta; cellular response to lipopolysaccharide; and defense response to other organism. Located in cytoplasmic vesicle and symbiont-containing vacuole membrane. Is expressed in several structures, including alimentary system; dorsal root ganglion; nasal cavity epithelium; vertebral axis musculature; and vibrissa. Orthologous to human GBP6 (guanylate binding protein family member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 7.3), liver E18 (RPKM 5.1) and 24 other tissues See more
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Genomic context

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See Gbp6 in Genome Data Viewer
Location:
5 E5; 5 50.68 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (105418568..105443733, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (105270702..105295871, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene 9640 Neighboring gene predicted gene, 31785 Neighboring gene guanylate-binding protein 10 Neighboring gene STARR-seq mESC enhancer starr_13849 Neighboring gene guanylate binding protein 11 Neighboring gene predicted gene, 26519

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defense. Degrandi D, et al. J Immunol, 2007 Dec 1. PMID 18025219
  2. A family of IFN-γ-inducible 65-kD GTPases protects against bacterial infection. Kim BH, et al. Science, 2011 May 6. PMID 21551061
  3. An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome. Bürckstümmer T, et al. Nat Immunol, 2009 Mar. PMID 19158679
  4. Assembly, verification, and initial annotation of the NIA mouse 7.4K cDNA clone set. VanBuren V, et al. Genome Res, 2002 Dec. PMID 12466305, Free PMC Article
  5. Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. Liu X, et al. BMC Immunol, 2016 Aug 2. PMID 27480124, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within adhesion of symbiont to host IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cellular response to interferon-beta IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to interferon-beta IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cellular response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to type II interferon IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cellular response to type II interferon IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in defense response to Gram-positive bacterium IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within defense response to Gram-positive bacterium IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within defense response to Gram-positive bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to protozoan IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within defense response to protozoan IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in symbiont-containing vacuole membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
guanylate-binding protein 6
Names
GTP-binding protein 6
guanine nucleotide-binding protein 6
macrophage activation 2 like
macrophage activation 2 like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_194336.2 → NP_919317.2  guanylate-binding protein 6

    See identical proteins and their annotated locations for NP_919317.2

    Status: VALIDATED

    Source sequence(s)
    AC123697, AK152226, BB657433, BQ562803, BX525828, BY159737
    Consensus CDS
    CCDS19492.1
    UniProtKB/Swiss-Prot
    A0A0G2JDV3, Q6PEN2, Q6ZQL8
    UniProtKB/TrEMBL
    A0A8Q0QEH4, L7N1X8
    Related
    ENSMUSP00000142518.2, ENSMUST00000196520.2
    Conserved Domains (2) summary
    pfam02263
    Location:16 → 279
    GBP; Guanylate-binding protein, N-terminal domain
    pfam02841
    Location:281 → 575
    GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    105418568..105443733 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534688.4 → XP_006534751.1  guanylate-binding protein 6 isoform X4

    UniProtKB/Swiss-Prot
    A0A0G2JDV3, Q6PEN2, Q6ZQL8
    UniProtKB/TrEMBL
    L7N1X8
    Conserved Domains (2) summary
    pfam02841
    Location:231 → 525
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl38936
    Location:10 → 229
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. XM_006534687.4 → XP_006534750.1  guanylate-binding protein 6 isoform X2

    See identical proteins and their annotated locations for XP_006534750.1

    UniProtKB/Swiss-Prot
    A0A0G2JDV3, Q6PEN2, Q6ZQL8
    UniProtKB/TrEMBL
    A0A8Q0QEH4, L7N1X8
    Conserved Domains (2) summary
    pfam02263
    Location:16 → 279
    GBP; Guanylate-binding protein, N-terminal domain
    pfam02841
    Location:281 → 575
    GBP_C; Guanylate-binding protein, C-terminal domain

  3. XM_006534690.5 → XP_006534753.2  guanylate-binding protein 6 isoform X3

    UniProtKB/TrEMBL
    Q05DL4
    Conserved Domains (2) summary
    pfam02841
    Location:258 → 552
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl38936
    Location:81 → 256
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  4. XM_006534689.5 → XP_006534752.1  guanylate-binding protein 6 isoform X5

    See identical proteins and their annotated locations for XP_006534752.1

    UniProtKB/TrEMBL
    Q05DL4
    Conserved Domains (2) summary
    pfam02841
    Location:204 → 498
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl38936
    Location:1 → 202
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  5. XM_011249385.4 → XP_011247687.1  guanylate-binding protein 6 isoform X1

    UniProtKB/Swiss-Prot
    A0A0G2JDV3, Q6PEN2, Q6ZQL8
    UniProtKB/TrEMBL
    L7N1X8
    Conserved Domains (2) summary
    pfam02263
    Location:105 → 368
    GBP; Guanylate-binding protein, N-terminal domain
    pfam02841
    Location:370 → 664
    GBP_C; Guanylate-binding protein, C-terminal domain

  6. XM_006534691.3 → XP_006534754.1  guanylate-binding protein 6 isoform X5

    See identical proteins and their annotated locations for XP_006534754.1

    UniProtKB/TrEMBL
    Q05DL4
    Conserved Domains (2) summary
    pfam02841
    Location:204 → 498
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl38936
    Location:1 → 202
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0G2JDV3.2 GenPept UniProtKB/Swiss-Prot:A0A0G2JDV3

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