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RFFL ring finger and FYVE like domain containing E3 ubiquitin protein ligase [ Sus scrofa (pig) ]

Gene ID: 100627054, updated on 17-Aug-2024

Summary

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Official Symbol
RFFLprovided by VGNC
Official Full Name
ring finger and FYVE like domain containing E3 ubiquitin protein ligaseprovided by VGNC
Primary source
VGNC:VGNC:98289
See related
Ensembl:ENSSSCG00000032552
Gene type
protein coding
RefSeq status
MODEL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression
Ubiquitous expression in ovary (RPKM 4.8), subcutaneous adipose (RPKM 4.1) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See RFFL in Genome Data Viewer
Location:
chromosome: 12
Exon count:
21
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 12 NC_010454.4 (40075259..40151034)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 12 NC_010454.3 (41676668..41712132)

Chromosome 12 - NC_010454.4Genomic Context describing neighboring genes Neighboring gene fibronectin type III domain containing 8 Neighboring gene RAD51 paralog D Neighboring gene transfer RNA glycine (anticodon GCC) Neighboring gene DNA ligase 3 Neighboring gene chaperonin containing TCP1 subunit 6B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein K48-linked ubiquitination IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase rififylin
Names
ring finger and FYVE-like domain containing 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010454.4 Reference Sscrofa11.1 Primary Assembly

    Range
    40075259..40151034
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_013981148.2 → XP_013836602.1  E3 ubiquitin-protein ligase rififylin isoform X6

    UniProtKB/TrEMBL
    A0A287AUW8, A0A8D0ID70
    Related
    ENSSSCP00000047905.3, ENSSSCT00000065635.3
    Conserved Domains (2) summary
    cd15770
    Location:44 → 92
    FYVE_CARP2; FYVE-like domain found in caspase regulator CARP2 and similar proteins
    pfam13920
    Location:284 → 328
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

  2. XM_021067420.1 → XP_020923079.1  E3 ubiquitin-protein ligase rififylin isoform X3

    UniProtKB/TrEMBL
    A0A287A6Z9, A0A8D0XCH3, A0A8D1HQL2, A0A8D1P3D4
    Related
    ENSSSCP00000022923.4, ENSSSCT00000027235.4
    Conserved Domains (2) summary
    cd15770
    Location:48 → 96
    FYVE_CARP2; FYVE-like domain found in caspase regulator CARP2 and similar proteins
    cd16500
    Location:319 → 357
    RING-HC_CARP; RING finger, HC subclass, found in caspases-8 and -10-associated RING finger protein CARP-1, CARP-2 and similar proteins

  3. XM_021067421.1 → XP_020923080.1  E3 ubiquitin-protein ligase rififylin isoform X3

    UniProtKB/TrEMBL
    A0A287A6Z9, A0A8D0XCH3, A0A8D1HQL2, A0A8D1P3D4
    Related
    ENSSSCP00000039652.3, ENSSSCT00000041104.3
    Conserved Domains (2) summary
    cd15770
    Location:48 → 96
    FYVE_CARP2; FYVE-like domain found in caspase regulator CARP2 and similar proteins
    cd16500
    Location:319 → 357
    RING-HC_CARP; RING finger, HC subclass, found in caspases-8 and -10-associated RING finger protein CARP-1, CARP-2 and similar proteins

  4. XM_021067427.1 → XP_020923086.1  E3 ubiquitin-protein ligase rififylin isoform X4

    UniProtKB/TrEMBL
    A0A0B8RTA4, A0A287B8W0, A0A8D0IHL3
    Conserved Domains (2) summary
    cd15770
    Location:44 → 92
    FYVE_CARP2; FYVE-like domain found in caspase regulator CARP2 and similar proteins
    cd16500
    Location:315 → 353
    RING-HC_CARP; RING finger, HC subclass, found in caspases-8 and -10-associated RING finger protein CARP-1, CARP-2 and similar proteins

  5. XM_021067423.1 → XP_020923082.1  E3 ubiquitin-protein ligase rififylin isoform X4

    UniProtKB/TrEMBL
    A0A0B8RTA4, A0A287B8W0, A0A8D0IHL3
    Related
    ENSSSCP00000052536.3, ENSSSCT00000047688.3
    Conserved Domains (2) summary
    cd15770
    Location:44 → 92
    FYVE_CARP2; FYVE-like domain found in caspase regulator CARP2 and similar proteins
    cd16500
    Location:315 → 353
    RING-HC_CARP; RING finger, HC subclass, found in caspases-8 and -10-associated RING finger protein CARP-1, CARP-2 and similar proteins

  6. XM_021067429.1 → XP_020923088.1  E3 ubiquitin-protein ligase rififylin isoform X4

    UniProtKB/TrEMBL
    A0A0B8RTA4, A0A287B8W0, A0A8D0IHL3
    Conserved Domains (2) summary
    cd15770
    Location:44 → 92
    FYVE_CARP2; FYVE-like domain found in caspase regulator CARP2 and similar proteins
    cd16500
    Location:315 → 353
    RING-HC_CARP; RING finger, HC subclass, found in caspases-8 and -10-associated RING finger protein CARP-1, CARP-2 and similar proteins

  7. XM_021067431.1 → XP_020923090.1  E3 ubiquitin-protein ligase rififylin isoform X4

    UniProtKB/TrEMBL
    A0A0B8RTA4, A0A287B8W0, A0A8D0IHL3
    Conserved Domains (2) summary
    cd15770
    Location:44 → 92
    FYVE_CARP2; FYVE-like domain found in caspase regulator CARP2 and similar proteins
    cd16500
    Location:315 → 353
    RING-HC_CARP; RING finger, HC subclass, found in caspases-8 and -10-associated RING finger protein CARP-1, CARP-2 and similar proteins

  8. XM_021067418.1 → XP_020923077.1  E3 ubiquitin-protein ligase rififylin isoform X3

    UniProtKB/TrEMBL
    A0A287A6Z9, A0A8D0XCH3, A0A8D1HQL2, A0A8D1P3D4
    Conserved Domains (2) summary
    cd15770
    Location:48 → 96
    FYVE_CARP2; FYVE-like domain found in caspase regulator CARP2 and similar proteins
    cd16500
    Location:319 → 357
    RING-HC_CARP; RING finger, HC subclass, found in caspases-8 and -10-associated RING finger protein CARP-1, CARP-2 and similar proteins

  9. XM_021067425.1 → XP_020923084.1  E3 ubiquitin-protein ligase rififylin isoform X4

    UniProtKB/TrEMBL
    A0A0B8RTA4, A0A287B8W0, A0A8D0IHL3
    Conserved Domains (2) summary
    cd15770
    Location:44 → 92
    FYVE_CARP2; FYVE-like domain found in caspase regulator CARP2 and similar proteins
    cd16500
    Location:315 → 353
    RING-HC_CARP; RING finger, HC subclass, found in caspases-8 and -10-associated RING finger protein CARP-1, CARP-2 and similar proteins

  10. XM_021067422.1 → XP_020923081.1  E3 ubiquitin-protein ligase rififylin isoform X3

    UniProtKB/TrEMBL
    A0A287A6Z9, A0A8D0XCH3, A0A8D1HQL2, A0A8D1P3D4
    Conserved Domains (2) summary
    cd15770
    Location:48 → 96
    FYVE_CARP2; FYVE-like domain found in caspase regulator CARP2 and similar proteins
    cd16500
    Location:319 → 357
    RING-HC_CARP; RING finger, HC subclass, found in caspases-8 and -10-associated RING finger protein CARP-1, CARP-2 and similar proteins

  11. XM_021067433.1 → XP_020923092.1  E3 ubiquitin-protein ligase rififylin isoform X4

    UniProtKB/TrEMBL
    A0A0B8RTA4, A0A287B8W0, A0A8D0IHL3
    Conserved Domains (2) summary
    cd15770
    Location:44 → 92
    FYVE_CARP2; FYVE-like domain found in caspase regulator CARP2 and similar proteins
    cd16500
    Location:315 → 353
    RING-HC_CARP; RING finger, HC subclass, found in caspases-8 and -10-associated RING finger protein CARP-1, CARP-2 and similar proteins

  12. XM_021067419.1 → XP_020923078.1  E3 ubiquitin-protein ligase rififylin isoform X3

    UniProtKB/TrEMBL
    A0A287A6Z9, A0A8D0XCH3, A0A8D1HQL2, A0A8D1P3D4
    Conserved Domains (2) summary
    cd15770
    Location:48 → 96
    FYVE_CARP2; FYVE-like domain found in caspase regulator CARP2 and similar proteins
    cd16500
    Location:319 → 357
    RING-HC_CARP; RING finger, HC subclass, found in caspases-8 and -10-associated RING finger protein CARP-1, CARP-2 and similar proteins

  13. XM_021067428.1 → XP_020923087.1  E3 ubiquitin-protein ligase rififylin isoform X4

    UniProtKB/TrEMBL
    A0A0B8RTA4, A0A287B8W0, A0A8D0IHL3
    Conserved Domains (2) summary
    cd15770
    Location:44 → 92
    FYVE_CARP2; FYVE-like domain found in caspase regulator CARP2 and similar proteins
    cd16500
    Location:315 → 353
    RING-HC_CARP; RING finger, HC subclass, found in caspases-8 and -10-associated RING finger protein CARP-1, CARP-2 and similar proteins

  14. XM_021067432.1 → XP_020923091.1  E3 ubiquitin-protein ligase rififylin isoform X4

    UniProtKB/TrEMBL
    A0A0B8RTA4, A0A287B8W0, A0A8D0IHL3
    Conserved Domains (2) summary
    cd15770
    Location:44 → 92
    FYVE_CARP2; FYVE-like domain found in caspase regulator CARP2 and similar proteins
    cd16500
    Location:315 → 353
    RING-HC_CARP; RING finger, HC subclass, found in caspases-8 and -10-associated RING finger protein CARP-1, CARP-2 and similar proteins

  15. XM_021067430.1 → XP_020923089.1  E3 ubiquitin-protein ligase rififylin isoform X4

    UniProtKB/TrEMBL
    A0A0B8RTA4, A0A287B8W0, A0A8D0IHL3
    Conserved Domains (2) summary
    cd15770
    Location:44 → 92
    FYVE_CARP2; FYVE-like domain found in caspase regulator CARP2 and similar proteins
    cd16500
    Location:315 → 353
    RING-HC_CARP; RING finger, HC subclass, found in caspases-8 and -10-associated RING finger protein CARP-1, CARP-2 and similar proteins

  16. XM_021067417.1 → XP_020923076.1  E3 ubiquitin-protein ligase rififylin isoform X2

    UniProtKB/TrEMBL
    A0A8D0R164, A0A8D0XCH3, A0A8D1HQL2
    Conserved Domains (2) summary
    cd15770
    Location:52 → 100
    FYVE_CARP2; FYVE-like domain found in caspase regulator CARP2 and similar proteins
    cd16500
    Location:323 → 361
    RING-HC_CARP; RING finger, HC subclass, found in caspases-8 and -10-associated RING finger protein CARP-1, CARP-2 and similar proteins

  17. XM_021067424.1 → XP_020923083.1  E3 ubiquitin-protein ligase rififylin isoform X4

    UniProtKB/TrEMBL
    A0A0B8RTA4, A0A287B8W0, A0A8D0IHL3
    Conserved Domains (2) summary
    cd15770
    Location:44 → 92
    FYVE_CARP2; FYVE-like domain found in caspase regulator CARP2 and similar proteins
    cd16500
    Location:315 → 353
    RING-HC_CARP; RING finger, HC subclass, found in caspases-8 and -10-associated RING finger protein CARP-1, CARP-2 and similar proteins

  18. XM_021067426.1 → XP_020923085.1  E3 ubiquitin-protein ligase rififylin isoform X4

    UniProtKB/TrEMBL
    A0A0B8RTA4, A0A287B8W0, A0A8D0IHL3
    Conserved Domains (2) summary
    cd15770
    Location:44 → 92
    FYVE_CARP2; FYVE-like domain found in caspase regulator CARP2 and similar proteins
    cd16500
    Location:315 → 353
    RING-HC_CARP; RING finger, HC subclass, found in caspases-8 and -10-associated RING finger protein CARP-1, CARP-2 and similar proteins

  19. XM_021067435.1 → XP_020923094.1  E3 ubiquitin-protein ligase rififylin isoform X7

    UniProtKB/TrEMBL
    A0A8D0XCH3, A0A8D1HQL2
    Conserved Domains (1) summary
    cd15770
    Location:60 → 108
    FYVE_CARP2; FYVE-like domain found in caspase regulator CARP2 and similar proteins

  20. XM_021067434.1 → XP_020923093.1  E3 ubiquitin-protein ligase rififylin isoform X5

    UniProtKB/TrEMBL
    A0A8D0UJE9
    Conserved Domains (2) summary
    cd15770
    Location:60 → 108
    FYVE_CARP2; FYVE-like domain found in caspase regulator CARP2 and similar proteins
    cd16500
    Location:303 → 341
    RING-HC_CARP; RING finger, HC subclass, found in caspases-8 and -10-associated RING finger protein CARP-1, CARP-2 and similar proteins

  21. XM_021067416.1 → XP_020923075.1  E3 ubiquitin-protein ligase rififylin isoform X1

    UniProtKB/TrEMBL
    A0A8D0XCH3, A0A8D1HQL2
    Conserved Domains (2) summary
    cd15770
    Location:60 → 108
    FYVE_CARP2; FYVE-like domain found in caspase regulator CARP2 and similar proteins
    cd16500
    Location:331 → 369
    RING-HC_CARP; RING finger, HC subclass, found in caspases-8 and -10-associated RING finger protein CARP-1, CARP-2 and similar proteins

  22. XM_003483058.4 → XP_003483106.1  E3 ubiquitin-protein ligase rififylin isoform X4

    See identical proteins and their annotated locations for XP_003483106.1

    UniProtKB/TrEMBL
    A0A0B8RTA4, A0A287B8W0, A0A8D0IHL3
    Conserved Domains (2) summary
    cd15770
    Location:44 → 92
    FYVE_CARP2; FYVE-like domain found in caspase regulator CARP2 and similar proteins
    cd16500
    Location:315 → 353
    RING-HC_CARP; RING finger, HC subclass, found in caspases-8 and -10-associated RING finger protein CARP-1, CARP-2 and similar proteins

  23. XM_021067436.1 → XP_020923095.1  E3 ubiquitin-protein ligase rififylin isoform X8

    UniProtKB/TrEMBL
    A0A8D0IHL3
    Conserved Domains (2) summary
    cd16500
    Location:256 → 294
    RING-HC_CARP; RING finger, HC subclass, found in caspases-8 and -10-associated RING finger protein CARP-1, CARP-2 and similar proteins
    cl28890
    Location:2 → 33
    FYVE_like_SF; FYVE domain like superfamily
Nucleotide Protein Strain
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