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PLCH2 phospholipase C eta 2 [ Sus scrofa (pig) ]

Gene ID: 100623940, updated on 17-Aug-2024

Summary

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Official Symbol
PLCH2provided by VGNC
Official Full Name
phospholipase C eta 2provided by VGNC
Primary source
VGNC:VGNC:91522
See related
Ensembl:ENSSSCG00000029744
Gene type
protein coding
RefSeq status
MODEL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression
Low expression observed in reference dataset See more
Orthologs
human mouse all
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Genomic context

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See PLCH2 in Genome Data Viewer
Location:
chromosome: 6
Exon count:
26
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 6 NC_010448.4 (64325918..64392070)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 6 NC_010448.3 (58630240..58696137, complement)

Chromosome 6 - NC_010448.4Genomic Context describing neighboring genes Neighboring gene retention in endoplasmic reticulum sorting receptor 1 Neighboring gene peroxisomal biogenesis factor 10 Neighboring gene pantothenate kinase 4 (inactive) Neighboring gene hes family bHLH transcription factor 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatidylinositol phospholipase C activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010448.4 Reference Sscrofa11.1 Primary Assembly

    Range
    64325918..64392070
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021095205.1 → XP_020950864.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X2

    UniProtKB/TrEMBL
    A0A8D0SLC5
    Conserved Domains (6) summary
    cd08633
    Location:302 → 704
    PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2
    cd13364
    Location:34 → 140
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    cd15898
    Location:158 → 187
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl26464
    Location:895 → 1196
    Atrophin-1; Atrophin-1 family
    cl27705
    Location:232 → 844
    PI-PLC-Y; Phosphatidylinositol-specific phospholipase C, Y domain
    cl28895
    Location:158 → 290
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes

  2. XM_013988723.2 → XP_013844177.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X1

    UniProtKB/TrEMBL
    A0A8D0SLC5, A0A8D1HXJ3, I3LUM3
    Related
    ENSSSCP00000027823.4, ENSSSCT00000031728.4
    Conserved Domains (7) summary
    cd00275
    Location:742 → 867
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08633
    Location:310 → 712
    PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2
    PLN02952
    Location:227 → 852
    PLN02952; phosphoinositide phospholipase C
    cd00051
    Location:158 → 224
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd13364
    Location:34 → 140
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    pfam09279
    Location:228 → 310
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    pfam13499
    Location:159 → 220
    EF-hand_7; EF-hand domain pair

  3. XM_013988725.2 → XP_013844179.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X4

    UniProtKB/TrEMBL
    A0A8D0SLC5
    Conserved Domains (7) summary
    cd00275
    Location:726 → 851
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08633
    Location:294 → 696
    PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2
    PLN02952
    Location:211 → 836
    PLN02952; phosphoinositide phospholipase C
    cd00051
    Location:142 → 208
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd13364
    Location:18 → 124
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    pfam09279
    Location:212 → 294
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    pfam13499
    Location:143 → 204
    EF-hand_7; EF-hand domain pair

  4. XM_013988724.2 → XP_013844178.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X3

    UniProtKB/TrEMBL
    A0A8D0SLC5
    Conserved Domains (7) summary
    cd00275
    Location:730 → 855
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08633
    Location:298 → 700
    PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2
    PLN02952
    Location:215 → 840
    PLN02952; phosphoinositide phospholipase C
    cd00051
    Location:146 → 212
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd13364
    Location:22 → 128
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    pfam09279
    Location:216 → 298
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    pfam13499
    Location:147 → 208
    EF-hand_7; EF-hand domain pair

  5. XM_013988726.2 → XP_013844180.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform X5

    UniProtKB/TrEMBL
    A0A8D0SLC5
    Conserved Domains (7) summary
    cd00275
    Location:712 → 837
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08633
    Location:280 → 682
    PI-PLCc_eta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta2
    PLN02952
    Location:197 → 822
    PLN02952; phosphoinositide phospholipase C
    cd00051
    Location:128 → 194
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd13364
    Location:4 → 110
    PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
    pfam09279
    Location:198 → 280
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    pfam13499
    Location:129 → 190
    EF-hand_7; EF-hand domain pair
Nucleotide Protein
Heading Accession and Version

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