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SHANK3 SH3 and multiple ankyrin repeat domains 3 [ Sus scrofa (pig) ]

Gene ID: 100622375, updated on 17-Aug-2024

Summary

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Official Symbol
SHANK3provided by VGNC
Official Full Name
SH3 and multiple ankyrin repeat domains 3provided by VGNC
Primary source
VGNC:VGNC:92836
Gene type
protein coding
RefSeq status
MODEL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression
Ubiquitous expression in lung (RPKM 11.4), subcutaneous adipose (RPKM 7.0) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See SHANK3 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
27
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 5 NC_010447.5 (41376..93033, complement)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) Unplaced Scaffold NW_003540984.1 (19976..65439)

Chromosome 5 - NC_010447.5Genomic Context describing neighboring genes Neighboring gene RAB, member of RAS oncogene family like 2B Neighboring gene uncharacterized LOC110260601 Neighboring gene acrosin Neighboring gene arylsulfatase A Neighboring gene mitogen-activated protein kinase 8 interacting protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ionotropic glutamate receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables synaptic receptor adaptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in dendritic spine IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
SH3 and multiple ankyrin repeat domains protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010447.5 Reference Sscrofa11.1 Primary Assembly

    Range
    41376..93033 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021091270.1 → XP_020946929.1  SH3 and multiple ankyrin repeat domains protein 3 isoform X3

    UniProtKB/TrEMBL
    A0A8D1INV5
    Conserved Domains (8) summary
    cd09506
    Location:1769 → 1834
    SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
    cd00204
    Location:250 → 408
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd00992
    Location:674 → 763
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00045
    Location:255 → 286
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:192 → 286
    Ank_2; Ankyrin repeats (3 copies)
    pfam16511
    Location:83 → 165
    FERM_f0; N-terminal or F0 domain of Talin-head FERM
    cl17036
    Location:550 → 575
    SH3; Src Homology 3 domain superfamily
    cl26386
    Location:1235 → 1438
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

  2. XM_021091273.1 → XP_020946932.1  SH3 and multiple ankyrin repeat domains protein 3 isoform X6

    UniProtKB/TrEMBL
    A0A8D1INV5
    Conserved Domains (8) summary
    cd09506
    Location:1744 → 1809
    SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
    cd00204
    Location:250 → 408
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd00992
    Location:649 → 738
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00045
    Location:255 → 286
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:192 → 286
    Ank_2; Ankyrin repeats (3 copies)
    pfam16511
    Location:83 → 165
    FERM_f0; N-terminal or F0 domain of Talin-head FERM
    cl17036
    Location:550 → 601
    SH3; Src Homology 3 domain superfamily
    cl26386
    Location:1210 → 1413
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

  3. XM_021091269.1 → XP_020946928.1  SH3 and multiple ankyrin repeat domains protein 3 isoform X2

    UniProtKB/TrEMBL
    A0A8D1INV5
    Conserved Domains (8) summary
    cd09506
    Location:1799 → 1864
    SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
    cd00204
    Location:250 → 408
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd00992
    Location:712 → 801
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00045
    Location:255 → 286
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:192 → 286
    Ank_2; Ankyrin repeats (3 copies)
    pfam16511
    Location:83 → 165
    FERM_f0; N-terminal or F0 domain of Talin-head FERM
    cl17036
    Location:550 → 601
    SH3; Src Homology 3 domain superfamily
    cl26386
    Location:1265 → 1468
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

  4. XM_021091267.1 → XP_020946926.1  SH3 and multiple ankyrin repeat domains protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A8D1INV5
    Conserved Domains (8) summary
    cd09506
    Location:1807 → 1872
    SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
    cd00204
    Location:250 → 408
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd00992
    Location:712 → 801
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00045
    Location:255 → 286
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:192 → 286
    Ank_2; Ankyrin repeats (3 copies)
    pfam16511
    Location:83 → 165
    FERM_f0; N-terminal or F0 domain of Talin-head FERM
    cl17036
    Location:550 → 601
    SH3; Src Homology 3 domain superfamily
    cl26386
    Location:1273 → 1476
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

  5. XM_021091268.1 → XP_020946927.1  SH3 and multiple ankyrin repeat domains protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A8D1INV5
    Conserved Domains (8) summary
    cd09506
    Location:1807 → 1872
    SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
    cd00204
    Location:250 → 408
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd00992
    Location:712 → 801
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00045
    Location:255 → 286
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:192 → 286
    Ank_2; Ankyrin repeats (3 copies)
    pfam16511
    Location:83 → 165
    FERM_f0; N-terminal or F0 domain of Talin-head FERM
    cl17036
    Location:550 → 601
    SH3; Src Homology 3 domain superfamily
    cl26386
    Location:1273 → 1476
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

  6. XM_021091271.1 → XP_020946930.1  SH3 and multiple ankyrin repeat domains protein 3 isoform X4

    UniProtKB/TrEMBL
    A0A480MZ18
    Conserved Domains (7) summary
    cd09506
    Location:1753 → 1818
    SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
    cd00204
    Location:196 → 354
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd00992
    Location:658 → 747
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00045
    Location:201 → 232
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:138 → 232
    Ank_2; Ankyrin repeats (3 copies)
    cl17036
    Location:496 → 547
    SH3; Src Homology 3 domain superfamily
    cl26386
    Location:1219 → 1422
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

  7. XM_021091272.1 → XP_020946931.1  SH3 and multiple ankyrin repeat domains protein 3 isoform X5

    UniProtKB/TrEMBL
    A0A480MZ18
    Conserved Domains (7) summary
    cd09506
    Location:1745 → 1810
    SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
    cd00204
    Location:188 → 346
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd00992
    Location:650 → 739
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00045
    Location:193 → 224
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:130 → 224
    Ank_2; Ankyrin repeats (3 copies)
    cl17036
    Location:488 → 539
    SH3; Src Homology 3 domain superfamily
    cl26386
    Location:1211 → 1414
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

  8. XM_021091274.1 → XP_020946933.1  SH3 and multiple ankyrin repeat domains protein 3 isoform X7

    UniProtKB/TrEMBL
    A0A480LLC0
    Conserved Domains (7) summary
    cd00204
    Location:250 → 408
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd00992
    Location:712 → 801
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00045
    Location:255 → 286
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:192 → 286
    Ank_2; Ankyrin repeats (3 copies)
    pfam16511
    Location:83 → 165
    FERM_f0; N-terminal or F0 domain of Talin-head FERM
    cl17036
    Location:550 → 601
    SH3; Src Homology 3 domain superfamily
    cl26386
    Location:1273 → 1476
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

  9. XM_021091275.1 → XP_020946934.1  SH3 and multiple ankyrin repeat domains protein 3 isoform X8

    UniProtKB/TrEMBL
    A0A480LLC0
    Conserved Domains (7) summary
    cd00204
    Location:250 → 408
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd00992
    Location:712 → 801
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00045
    Location:255 → 286
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:192 → 286
    Ank_2; Ankyrin repeats (3 copies)
    pfam16511
    Location:83 → 165
    FERM_f0; N-terminal or F0 domain of Talin-head FERM
    cl17036
    Location:550 → 601
    SH3; Src Homology 3 domain superfamily
    cl26386
    Location:1273 → 1476
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
Nucleotide Protein
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