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MIR4471 microRNA 4471 [ Homo sapiens (human) ]

Gene ID: 100616451, updated on 10-Oct-2023

Summary

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Official Symbol
MIR4471provided by HGNC
Official Full Name
microRNA 4471provided by HGNC
Primary source
HGNC:HGNC:41657
See related
Ensembl:ENSG00000265599 miRBase:MI0016822; AllianceGenome:HGNC:41657
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

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Location:
8q22.2
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (100382763..100382845)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (101507552..101507634)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (101394991..101395073)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27687 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27688 Neighboring gene ring finger protein 19A, RBR E3 ubiquitin protein ligase Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19413 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19414 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19415 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:101322379-101322538 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27689 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27690 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27691 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:101347648-101348460 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:101348461-101349272 Neighboring gene uncharacterized LOC124901991 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27692 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27693 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27694 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:101421928-101423127 Neighboring gene RNF19A-ANKRD46 intergenic CAGE-defined high expression enhancer Neighboring gene uncharacterized LOC124901990 Neighboring gene uncharacterized LOC105375670 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27696 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27697 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27699 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27698 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27700 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr8:101455271-101456130 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27702 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:101470299-101470976 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:101471860-101472360 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:101472361-101472861 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:101477753-101478339 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27703 Neighboring gene uncharacterized LOC124901992 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:101499786-101500985 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:101503341-101504286 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27704 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27705 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27706 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27707 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27708 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr8:101506997-101507937 and GRCh37_chr8:101507938-101508879 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr8:101508880-101509820 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:101511587-101512088 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:101512089-101512588

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Exosomal microRNA-4535 of Melanoma Stem Cells Promotes Metastasis by Inhibiting Autophagy Pathway. Liu D, et al. Stem Cell Rev Rep, 2023 Jan. PMID 35296991
  2. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. Jima DD, et al. Blood, 2010 Dec 2. PMID 20733160, Free PMC Article
  3. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. Persson H, et al. Cancer Res, 2011 Jan 1. PMID 21199797
  4. miRBase: microRNA sequences, targets and gene nomenclature. Griffiths-Jones S, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381832, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Exosomal microRNA-4535 of Melanoma Stem Cells Promotes Metastasis by Inhibiting Autophagy Pathway.
    Title: Exosomal microRNA-4535 of Melanoma Stem Cells Promotes Metastasis by Inhibiting Autophagy Pathway.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Other Names

  • hsa-mir-4471

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_039681.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AP003472
    Related
    ENST00000584480.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    100382763..100382845
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    101507552..101507634
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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