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MIR4681 microRNA 4681 [ Homo sapiens (human) ]

Gene ID: 100616398, updated on 10-Oct-2023

Summary

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Official Symbol
MIR4681provided by HGNC
Official Full Name
microRNA 4681provided by HGNC
Primary source
HGNC:HGNC:41753
See related
Ensembl:ENSG00000265719 miRBase:MI0017313; AllianceGenome:HGNC:41753
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

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Location:
10q26.11
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (119377972..119378043)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (120273841..120273912)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (121137484..121137555)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:120981885-120982396 Neighboring gene RNA, 7SL, cytoplasmic 749, pseudogene Neighboring gene Sharpr-MPRA regulatory region 13114 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4108 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:121000275-121000776 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121001445-121002011 Neighboring gene G protein-coupled receptor kinase 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4110 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4109 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121040606-121041106 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121048231-121048730 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4111 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4112 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4114 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:121074255-121075454 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:121076215-121076848 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:121076849-121077482 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:121077483-121078116 Neighboring gene uncharacterized LOC105378511 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121100212-121100805 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121100806-121101398 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121108919-121109420 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4118 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121150987-121151487 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:121160908-121162107 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121164620-121165120 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_10067 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121203591-121204381 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121210069-121210568 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:121211884-121212060 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121214023-121214544 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4119 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121225296-121225796 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4120 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:121239005-121239584 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4121 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121269325-121269826 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121269827-121270326 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:121274963-121275176 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:121275942-121276524 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4122 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4123 Neighboring gene regulator of G protein signaling 10 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4124 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2874 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2875 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2876 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2877 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4125 Neighboring gene NANOG hESC enhancer GRCh37_chr10:121303486-121303994 Neighboring gene uncharacterized LOC105378512 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2878 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:121355707-121356705 Neighboring gene TIA1 cytotoxic granule associated RNA binding protein like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. Persson H, et al. Cancer Res, 2011 Jan 1. PMID 21199797
  2. miRBase: microRNA sequences, targets and gene nomenclature. Griffiths-Jones S, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381832, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Other Names

  • hsa-mir-4681

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_039829.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AL583824
    Related
    ENST00000580598.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    119377972..119378043
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    120273841..120273912
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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