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MIR4492 microRNA 4492 [ Homo sapiens (human) ]

Gene ID: 100616376, updated on 12-Feb-2024

Summary

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Official Symbol
MIR4492provided by HGNC
Official Full Name
microRNA 4492provided by HGNC
Primary source
HGNC:HGNC:41563
See related
Ensembl:ENSG00000264211 miRBase:MI0016854; AllianceGenome:HGNC:41563
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
mir-4492
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

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Location:
11q23.3
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (118910708..118910787)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (118930944..118931023)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (118781417..118781496)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5602 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5603 Neighboring gene SET pseudogene 16 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5604 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3955 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3956 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5605 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5606 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5607 Neighboring gene uncharacterized LOC124902767 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:118758848-118759465 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:118766473-118767231 Neighboring gene C-X-C motif chemokine receptor 5 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:118768851-118769358 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5608 Neighboring gene BCL9 like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:118779970-118780511 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:118781595-118782134 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:118782402-118783601 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5609 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:118784843-118785382 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:118785383-118785924 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:118787549-118788090 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:118788631-118789172 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:118792419-118792959 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:118794043-118794583 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:118794584-118795123 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5610 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:118795793-118796294 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3957 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3958 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3959 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:118798447-118798948 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5611 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5612 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5613 Neighboring gene RNA, 7SL, cytoplasmic 688, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:118810343-118811124 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:118811125-118811904 Neighboring gene uroplakin 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Long noncoding RNA LINC00319 regulates ROMO1 expression and promotes bladder cancer progression via miR-4492/ROMO1 axis. Yang Y, et al. J Cell Physiol, 2020 Apr. PMID 31608995
  2. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. Jima DD, et al. Blood, 2010 Dec 2. PMID 20733160, Free PMC Article
  3. miRBase: integrating microRNA annotation and deep-sequencing data. Kozomara A, et al. Nucleic Acids Res, 2011 Jan. PMID 21037258, Free PMC Article
  4. miRBase: microRNA sequences, targets and gene nomenclature. Griffiths-Jones S, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381832, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. IL-17 promotes IL-18 production via the MEK/ERK/miR-4492 axis in osteoarthritis synovial fibroblasts.
    Title: IL-17 promotes IL-18 production via the MEK/ERK/miR-4492 axis in osteoarthritis synovial fibroblasts.
  2. Long noncoding RNA LINC00319 regulates ROMO1 expression and promotes bladder cancer progression via miR-4492/ROMO1 axis.
    Title: Long noncoding RNA LINC00319 regulates ROMO1 expression and promotes bladder cancer progression via miR-4492/ROMO1 axis.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Other Names

  • hsa-mir-4492

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_039713.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AP004609
    Related
    ENST00000581627.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    118910708..118910787
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    118930944..118931023
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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