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MIR4659B microRNA 4659b [ Homo sapiens (human) ]

Gene ID: 100616372, updated on 8-Nov-2023

Summary

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Official Symbol
MIR4659Bprovided by HGNC
Official Full Name
microRNA 4659bprovided by HGNC
Primary source
HGNC:HGNC:41530
See related
Ensembl:ENSG00000283386 miRBase:MI0017291; AllianceGenome:HGNC:41530
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

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See MIR4659B in Genome Data Viewer
Location:
8p23.1
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (6745168..6745240, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (6500242..6500314, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (6602689..6602761, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene microcephalin 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:6481178-6481678 Neighboring gene MCPH1 antisense RNA 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:6505663-6506862 Neighboring gene microRNA 8055 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18882 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26948 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26949 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26950 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26951 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26952 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18883 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18884 Neighboring gene protein tyrosine phosphatase non-receptor type 4 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18885 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26953 Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26954 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26955 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18886 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26956 Neighboring gene Sharpr-MPRA regulatory region 12268 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26957 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:6611625-6612126 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:6612127-6612626 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26958 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:6624955-6625205 Neighboring gene microRNA 4659a Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26959 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26960 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:6631643-6632143 Neighboring gene uncharacterized LOC124901872 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18887 Neighboring gene uncharacterized LOC107986909 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:6662895-6663395

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. Persson H, et al. Cancer Res, 2011 Jan 1. PMID 21199797
  2. miRBase: microRNA sequences, targets and gene nomenclature. Griffiths-Jones S, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381832, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Other Names

  • hsa-mir-4659b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_039807.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AF287957
    Related
    ENST00000636806.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    6745168..6745240 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_018654717.1 Reference GRCh38.p14 PATCHES

    Range
    140438..140510 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    6500242..6500314 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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