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MIR4425 microRNA 4425 [ Homo sapiens (human) ]

Gene ID: 100616365, updated on 17-Sep-2024

Summary

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Official Symbol
MIR4425provided by HGNC
Official Full Name
microRNA 4425provided by HGNC
Primary source
HGNC:HGNC:41891
See related
Ensembl:ENSG00000264371 miRBase:MI0016764; AllianceGenome:HGNC:41891
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

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See MIR4425 in Genome Data Viewer
Location:
1p36.11
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (25023503..25023586)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (24859312..24859395)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (25349994..25350077)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RUNX family transcription factor 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 412 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:25254973-25255707 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:25255708-25256441 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 443 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:25257881-25258470 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 444 Neighboring gene microRNA 6731 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 445 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:25264973-25265472 Neighboring gene RUNX3 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 414 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:25276177-25276700 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:25276701-25277226 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 415 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 446 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:25281264-25282463 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 419 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 420 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 421 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 447 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 422 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 423 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 448 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 424 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 425 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 426 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 427 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:25310883-25311384 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 449 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:25316159-25316660 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 428 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 429 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 431 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 432 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 430 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:25345941-25346837 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:25347096-25347624 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:25347625-25348151 Neighboring gene enhancer 2 sub-fragment of super enhancer upstream of RUNX3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:25351623-25352296 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:25353935-25354474 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:25354475-25355012 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:25355013-25355552 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 437 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 450 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 438 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 439 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 440 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 441 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:25372889-25373429 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:25373430-25373969 Neighboring gene long intergenic non-protein coding RNA 2793 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:25378080-25378598 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:25381310-25381813 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:25398512-25399127 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:25417097-25418296 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 443 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 451 Neighboring gene MPRA-validated peak123 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 444 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 445 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 446 Neighboring gene IFITM3 pseudogene 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. Jima DD, et al. Blood, 2010 Dec 2. PMID 20733160, Free PMC Article
  2. miRBase: microRNA sequences, targets and gene nomenclature. Griffiths-Jones S, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381832, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Other Names

  • hsa-mir-4425

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_039623.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AL050344
    Related
    ENST00000580572.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    25023503..25023586
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    24859312..24859395
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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