U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

MIR4774 microRNA 4774 [ Homo sapiens (human) ]

Gene ID: 100616356, updated on 10-Oct-2023

Summary

Go to the top of the page Help
Official Symbol
MIR4774provided by HGNC
Official Full Name
microRNA 4774provided by HGNC
Primary source
HGNC:HGNC:41873
See related
Ensembl:ENSG00000265694 miRBase:MI0017417; AllianceGenome:HGNC:41873
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See MIR4774 in Genome Data Viewer
Location:
2q24.3
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (168582943..168583018)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (169040435..169040510)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (169439453..169439528)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373734 Neighboring gene NANOG hESC enhancer GRCh37_chr2:169211617-169212118 Neighboring gene uncharacterized LOC102724081 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16731 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16732 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12077 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12078 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12079 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12080 Neighboring gene RNA, 7SL, cytoplasmic 813, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16733 Neighboring gene ceramide synthase 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:169406684-169407255 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:169407256-169407826 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16734 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16735 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12081 Neighboring gene NANOG hESC enhancer GRCh37_chr2:169459973-169460474 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:169471049-169471548 Neighboring gene RNA, U6 small nuclear 766, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16736 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:169592586-169593086 Neighboring gene CERS6 antisense RNA 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Discovery of new microRNAs by small RNAome deep sequencing in childhood acute lymphoblastic leukemia. Schotte D, et al. Leukemia, 2011 Sep. PMID 21606961
  2. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. Persson H, et al. Cancer Res, 2011 Jan 1. PMID 21199797
  3. miRBase: microRNA sequences, targets and gene nomenclature. Griffiths-Jones S, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381832, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

Go to the top of the page Help

Other Names

  • hsa-mir-4774

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_039933.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AC019086
    Related
    ENST00000583305.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    168582943..168583018
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    169040435..169040510
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Miscellaneous