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MIR3974 microRNA 3974 [ Homo sapiens (human) ]

Gene ID: 100616279, updated on 17-Sep-2024

Summary

Official Symbol
MIR3974provided by HGNC
Official Full Name
microRNA 3974provided by HGNC
Primary source
HGNC:HGNC:41672
See related
Ensembl:ENSG00000283665 miRBase:MI0016992; AllianceGenome:HGNC:41672
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

See MIR3974 in Genome Data Viewer
Location:
12p12.3
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (17673299..17673394)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (17549501..17549596)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (17826233..17826328)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902888 Neighboring gene long intergenic non-protein coding RNA 2378 Neighboring gene uncharacterized LOC124902889 Neighboring gene VISTA enhancer hs579 Neighboring gene VISTA enhancer hs980 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:18102760-18103303 Neighboring gene RERG like Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:18306612-18307209 Neighboring gene uncharacterized LOC124903122

Genomic regions, transcripts, and products

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_039770.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AC087321
    Related
    ENST00000637126.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    17673299..17673394
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    17549501..17549596
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)