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MIR4662A microRNA 4662a [ Homo sapiens (human) ]

Gene ID: 100616221, updated on 10-Oct-2023

Summary

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Official Symbol
MIR4662Aprovided by HGNC
Official Full Name
microRNA 4662aprovided by HGNC
Primary source
HGNC:HGNC:41826
See related
Ensembl:ENSG00000283609 miRBase:MI0017290; AllianceGenome:HGNC:41826
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

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See MIR4662A in Genome Data Viewer
Location:
8q24.13
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (124821985..124822051)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (125955163..125955229)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (125834227..125834293)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene MTSS I-BAR domain containing 1 Neighboring gene uncharacterized LOC124902016 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27889 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:125632749-125633948 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:125638519-125639718 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27890 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27891 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27892 Neighboring gene Sharpr-MPRA regulatory region 10356 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27893 Neighboring gene Sharpr-MPRA regulatory region 2678 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27895 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27894 Neighboring gene Sharpr-MPRA regulatory region 8202 Neighboring gene uncharacterized LOC105375741 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:125764038-125764579 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19515 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:125810571-125811072 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:125811073-125811572 Neighboring gene uncharacterized LOC105375743 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:125846921-125847424 Neighboring gene microRNA 4662b Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:125860005-125861204 Neighboring gene MRS2 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Deep sequencing of small RNAs from human skin reveals major alterations in the psoriasis miRNAome. Joyce CE, et al. Hum Mol Genet, 2011 Oct 15. PMID 21807764, Free PMC Article
  2. miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades. Friedländer MR, et al. Nucleic Acids Res, 2012 Jan. PMID 21911355, Free PMC Article
  3. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. Persson H, et al. Cancer Res, 2011 Jan 1. PMID 21199797
  4. miRBase: microRNA sequences, targets and gene nomenclature. Griffiths-Jones S, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381832, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Other Names

  • hsa-mir-4662a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_039806.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AC100858
    Related
    ENST00000637499.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    124821985..124822051
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    125955163..125955229
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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