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MIR4466 microRNA 4466 [ Homo sapiens (human) ]

Gene ID: 100616154, updated on 10-Oct-2023

Summary

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Official Symbol
MIR4466provided by HGNC
Official Full Name
microRNA 4466provided by HGNC
Primary source
HGNC:HGNC:41726
See related
Ensembl:ENSG00000271899 miRBase:MI0016817; AllianceGenome:HGNC:41726
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
mir-4466
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

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Location:
6q25.3
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (156779678..156779731, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (157981929..157981982, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (157100812..157100865, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901444 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:157007142-157008069 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:157008070-157008996 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25313 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25314 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:157029670-157029847 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17707 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25315 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:157042423-157042971 Neighboring gene MPRA-validated peak6246 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25316 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25317 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25318 Neighboring gene Sharpr-MPRA regulatory region 1028 Neighboring gene uncharacterized LOC115308161 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17708 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:157099729-157100264 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17712 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17710 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17711 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17709 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17715 Neighboring gene MPRA-validated peak6247 silencer Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr6:157141145-157141772 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17716 Neighboring gene AT-rich interaction domain 1B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:157150990-157151957 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:157173517-157174214 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:157174215-157174910 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25319 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25320 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17717 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:157234632-157235132 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25321 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:157263165-157263666 Neighboring gene Sharpr-MPRA regulatory region 494 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:157267096-157267823 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:157266367-157267095 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25322 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25323 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25324 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:157283836-157284476 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25325 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17718 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17719 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:157369601-157370102 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:157370103-157370603 Neighboring gene MPRA-validated peak6251 silencer Neighboring gene MPRA-validated peak6252 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25326 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25327 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25328 Neighboring gene NANOG hESC enhancer GRCh37_chr6:157402195-157402696 Neighboring gene MPRA-validated peak6253 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:157466013-157466862 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:157466863-157467711 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:157471440-157471940 Neighboring gene Sharpr-MPRA regulatory region 1838 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:157507076-157507576 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:157507577-157508077 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:157528125-157528624 Neighboring gene uncharacterized LOC124901445 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:157548108-157548608 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:157548609-157549109 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:157552291-157552791 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:157638855-157639639 Neighboring gene uncharacterized LOC105378075

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. Jima DD, et al. Blood, 2010 Dec 2. PMID 20733160, Free PMC Article
  2. miRBase: integrating microRNA annotation and deep-sequencing data. Kozomara A, et al. Nucleic Acids Res, 2011 Jan. PMID 21037258, Free PMC Article
  3. miRBase: microRNA sequences, targets and gene nomenclature. Griffiths-Jones S, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381832, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Other Names

  • hsa-mir-4466

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_039676.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AL355297
    Related
    ENST00000606121.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    156779678..156779731 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    157981929..157981982 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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