MIR4458 microRNA 4458 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MIR4458provided by HGNC
Official Full Name: microRNA 4458provided by HGNC
Primary source: HGNC:HGNC:41674
See related: Ensembl:ENSG00000284000 miRBase:MI0016804; AllianceGenome:HGNC:41674
Gene type: ncRNA
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: mir-4458
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

Location:: 5p15.31

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (8460925..8460999)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (8400787..8400861)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (8461038..8461112)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Circular RNA circHMCU promotes breast tumorigenesis through miR-4458/PGK1 regulatory cascade.
Title: Circular RNA circHMCU promotes breast tumorigenesis through miR-4458/PGK1 regulatory cascade.
MicroRNA-4458 Regulates PD-L1 Expression to Enhance Anti-tumor Immunity in NSCLC via Targeting STAT3.
Title: MicroRNA-4458 Regulates PD-L1 Expression to Enhance Anti-tumor Immunity in NSCLC via Targeting STAT3.
LINC00963/miR-4458 regulates the effect of oxaliplatin in gastric cancer by mediating autophagic flux through targeting of ATG16L1.
Title: LINC00963/miR-4458 regulates the effect of oxaliplatin in gastric cancer by mediating autophagic flux through targeting of ATG16L1.
LINC00665 promotes the progression of acute myeloid leukemia by regulating the miR-4458/DOCK1 pathway.
Title: LINC00665 promotes the progression of acute myeloid leukemia by regulating the miR-4458/DOCK1 pathway.
MiR-4458/human antigen R (HuR) modulates PBX3 mRNA stability in melanoma tumorigenesis.
Title: MiR-4458/human antigen R (HuR) modulates PBX3 mRNA stability in melanoma tumorigenesis.
Circular RNA circ_0000337 contributes to osteosarcoma via the miR-4458/BACH1 pathway.
Title: Circular RNA circ_0000337 contributes to osteosarcoma via the miR-4458/BACH1 pathway.
miR-4458 inhibits the epithelial-mesenchymal transition of hepatocellular carcinoma cells by suppressing the TGF-beta signaling pathway via targeting TGFBR1.
Title: miR-4458 inhibits the epithelial-mesenchymal transition of hepatocellular carcinoma cells by suppressing the TGF-β signaling pathway via targeting TGFBR1.
Long non-coding RNA CDKN2B-AS1 promotes osteosarcoma by increasing the expression of MAP3K3 via sponging miR-4458.
Title: Long non-coding RNA CDKN2B-AS1 promotes osteosarcoma by increasing the expression of MAP3K3 via sponging miR-4458.
miR-4458 regulates cell proliferation and apoptosis through targeting SOCS1 in triple-negative breast cancer.
Title: miR-4458 regulates cell proliferation and apoptosis through targeting SOCS1 in triple-negative breast cancer.
MiR-4458 inhibits breast cancer cell growth, migration, and invasiveness by targeting CPSF4; results suggest that the miR-4458-CPSF4-COX-2-hTERT axis might serve as a potential target for the treatment of breast cancer patients
Title: MiR-4458 inhibits breast cancer cell growth, migration, and invasiveness by targeting CPSF4.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Phenotypes

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Variation

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General gene information

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NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.