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HSPG2 heparan sulfate proteoglycan 2 [ Nomascus leucogenys (northern white-cheeked gibbon) ]

Gene ID: 100603335, updated on 8-Mar-2024

Summary

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Gene symbol
HSPG2
Gene description
heparan sulfate proteoglycan 2
See related
EnsemblRapid:ENSNLEG00000008145
Gene type
protein coding
RefSeq status
MODEL
Organism
Nomascus leucogenys
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae; Nomascus
Orthologs
human mouse all
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Genomic context

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See HSPG2 in Genome Data Viewer
Location:
chromosome: 24
Exon count:
99
Annotation release Status Assembly Chr Location
103 current Asia_NLE_v1 (GCF_006542625.1) 24 NC_044404.1 (21846019..21948877, complement)
102 previous assembly Nleu_3.0 (GCF_000146795.2) 24 NC_019839.1 (20886214..20994660, complement)

Chromosome 24 - NC_044404.1Genomic Context describing neighboring genes Neighboring gene RAP1 GTPase activating protein Neighboring gene ubiquitin specific peptidase 48 Neighboring gene U7 small nuclear RNA Neighboring gene low density lipoprotein receptor class A domain containing 2 Neighboring gene U6 spliceosomal RNA Neighboring gene U6 spliceosomal RNA Neighboring gene chymotrypsin like elastase 3B Neighboring gene chymotrypsin like elastase 3A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cell adhesion molecule binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cell-cell junction IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
basement membrane-specific heparan sulfate proteoglycan core protein

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Nomascus leucogenys Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Asia_NLE_v1 Primary Assembly

Genomic

  1. NC_044404.1 Reference Asia_NLE_v1 Primary Assembly

    Range
    21846019..21948877 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030805509.1 → XP_030661369.1  basement membrane-specific heparan sulfate proteoglycan core protein

    UniProtKB/TrEMBL
    G1R9T4
    Related
    ENSNLEP00000009980.3, ENSNLET00000010465.3
    Conserved Domains (16) summary
    cd05743
    Location:539 → 616
    Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2, and similar domains
    cd05754
    Location:1889 → 1974
    Ig_Perlecan_like; Igmmunoglobulin (Ig)-like domain found in Perlecan and similar proteins
    smart00200
    Location:198 → 312
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    smart00281
    Location:1103 → 1230
    LamB; Laminin B domain
    smart00409
    Location:2175 → 2252
    IG; Immunoglobulin
    smart00410
    Location:2276 → 2353
    IG_like; Immunoglobulin like
    cd00054
    Location:3970 → 3999
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:1276 → 1325
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:4321 → 4480
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00112
    Location:403 → 437
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00008
    Location:4226 → 4256
    EGF; EGF-like domain
    pfam00052
    Location:713 → 847
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:1393 → 1440
    Laminin_EGF; Laminin EGF domain
    pfam00057
    Location:315 → 352
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam07679
    Location:2074 → 2160
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:3535 → 3601
    Ig; Immunoglobulin domain
Nucleotide Protein
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