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FASN fatty acid synthase [ Nomascus leucogenys (northern white-cheeked gibbon) ]

Gene ID: 100597701, updated on 8-Mar-2024

Summary

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Gene symbol
FASN
Gene description
fatty acid synthase
See related
EnsemblRapid:ENSNLEG00000014036
Gene type
protein coding
RefSeq status
MODEL
Organism
Nomascus leucogenys
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae; Nomascus
Orthologs
human mouse all
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Genomic context

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See FASN in Genome Data Viewer
Location:
chromosome: 14
Exon count:
43
Annotation release Status Assembly Chr Location
103 current Asia_NLE_v1 (GCF_006542625.1) 14 NC_044394.1 (84675457..84695219)
102 previous assembly Nleu_3.0 (GCF_000146795.2) 14 NC_019829.1 (86518151..86535276)

Chromosome 14 - NC_044394.1Genomic Context describing neighboring genes Neighboring gene casein kinase 1 delta Neighboring gene solute carrier family 16 member 3 Neighboring gene coiled-coil domain containing 57 Neighboring gene small nucleolar RNA U13 Neighboring gene dihydrouridine synthase 1 like Neighboring gene G protein pathway suppressor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 3-oxoacyl-[acyl-carrier-protein] synthase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables fatty acid synthase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphopantetheine binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
fatty acid synthase

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Nomascus leucogenys Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Asia_NLE_v1 Primary Assembly

Genomic

  1. NC_044394.1 Reference Asia_NLE_v1 Primary Assembly

    Range
    84675457..84695219
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030827567.1 → XP_030683427.1  fatty acid synthase

    UniProtKB/TrEMBL
    G1RUY3
    Related
    ENSNLEP00000017060.3, ENSNLET00000017920.3
    Conserved Domains (10) summary
    cd08954
    Location:1876 → 2111
    KR_1_FAS_SDR_x; beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 1, complex (x) SDRs
    smart00823
    Location:2110 → 2178
    PKS_PP; Phosphopantetheine attachment site
    smart00826
    Location:874 → 1008
    PKS_DH; Dehydratase domain in polyketide synthase (PKS) enzymes
    smart00829
    Location:1564 → 1854
    PKS_ER; Enoylreductase
    cd00833
    Location:2 → 404
    PKS; polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or ...
    pfam00698
    Location:493 → 809
    Acyl_transf_1; Acyl transferase domain
    pfam00975
    Location:2241 → 2500
    Thioesterase; Thioesterase domain
    pfam08242
    Location:1243 → 1341
    Methyltransf_12; Methyltransferase domain
    pfam16197
    Location:362 → 472
    KAsynt_C_assoc; Ketoacyl-synthetase C-terminal extension
    cl21454
    Location:1316 → 1522
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  2. XM_030827568.1 → XP_030683428.1  fatty acid synthase

    UniProtKB/TrEMBL
    G1RUY3
Nucleotide Protein
Heading Accession and Version

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