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mapk8ip1a mitogen-activated protein kinase 8 interacting protein 1a [ Danio rerio (zebrafish) ]

Gene ID: 100537717, updated on 2-Nov-2024

Summary

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Official Symbol
mapk8ip1aprovided by ZNC
Official Full Name
mitogen-activated protein kinase 8 interacting protein 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-101025-1
See related
Ensembl:ENSDARG00000102229 AllianceGenome:ZFIN:ZDB-GENE-101025-1
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
mapk8ip1
Summary
Predicted to enable JUN kinase binding activity and MAP-kinase scaffold activity. Predicted to be involved in JNK cascade. Predicted to act upstream of or within phosphorylation and regulation of JNK cascade. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human MAPK8IP1 (mitogen-activated protein kinase 8 interacting protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See mapk8ip1a in Genome Data Viewer
Location:
chromosome: 25
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (13801716..13842618, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (13705316..13746461, complement)

Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene centriolar satellite-associated tubulin polyglutamylase complex regulator 1 Neighboring gene coiled-coil domain containing 135 Neighboring gene uncharacterized LOC110438383 Neighboring gene cytoskeleton associated protein 5 Neighboring gene cryptochrome circadian regulator 2 Neighboring gene carbohydrate (keratan sulfate Gal-6) sulfotransferase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Identification of zebrafish magnetoreceptor and cryptochrome homologs. Zhou Z, et al. Sci China Life Sci, 2016 Dec. PMID 27614751
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  3. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables JUN kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MAP-kinase scaffold activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of JNK cascade IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
C-Jun-amino-terminal kinase-interacting protein 1a
Names
mitogen-activated protein kinase 8 interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001351666.1 → NP_001338595.1  C-Jun-amino-terminal kinase-interacting protein 1a

    Status: VALIDATED

    Source sequence(s)
    CU855901
    UniProtKB/TrEMBL
    A0A0R4IB08, A0A8M1PAR0
    Related
    ENSDARP00000131169.1, ENSDART00000160258.2
    Conserved Domains (2) summary
    cd11943
    Location:543 → 597
    SH3_JIP1; Src homology 3 domain of JNK-interacting protein 1
    cd01212
    Location:611 → 759
    PTB_JIP; JNK-interacting protein-like (JIP) Phosphotyrosine-binding (PTB) domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007136.7 Reference GRCz11 Primary Assembly

    Range
    13801716..13842618 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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