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mcc MCC regulator of WNT signaling pathway [ Danio rerio (zebrafish) ]

Gene ID: 100537329, updated on 2-Nov-2024

Summary

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Official Symbol
mccprovided by ZNC
Official Full Name
MCC regulator of WNT signaling pathwayprovided by ZNC
Primary source
ZFIN:ZDB-GENE-141210-1
See related
Ensembl:ENSDARG00000105237 AllianceGenome:ZFIN:ZDB-GENE-141210-1
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable calcium ion binding activity. Acts upstream of or within convergent extension involved in gastrulation. Is expressed in several structures, including blastomere; digestive system; germ ring; swim bladder; and trunk. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human MCC (MCC regulator of WNT signaling pathway). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See mcc in Genome Data Viewer
Location:
chromosome: 5
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (1668089..1827547, complement)
105 previous assembly GRCz10 (GCF_000002035.5) Unplaced Scaffold NW_003334319.1 (393..67114)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene myosin, light chain 2a, regulatory, cardiac, slow Neighboring gene protein phosphatase 1, catalytic subunit, gamma isozyme Neighboring gene uncharacterized LOC137495506 Neighboring gene microRNA 101b Neighboring gene RNA terminal phosphate cyclase-like 1 Neighboring gene zgc:101699 Neighboring gene uncharacterized LOC110439839

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Characterization and expression pattern of ZB and PS transposons in zebrafish. Wang Y, et al. Gene Expr Patterns, 2021 Dec. PMID 34481069
  2. The PDZ domain protein Mcc is a novel effector of non-canonical Wnt signaling during convergence and extension in zebrafish. Young T, et al. Development, 2014 Sep. PMID 25183869
  3. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The PDZ domain protein Mcc is a novel effector of non-canonical Wnt signaling during convergence and extension in zebrafish.
    Title: The PDZ domain protein Mcc is a novel effector of non-canonical Wnt signaling during convergence and extension in zebrafish.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within convergent extension involved in gastrulation IGI
Inferred from Genetic Interaction
more info
 PubMed 

General protein information

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Preferred Names
colorectal mutant cancer protein
Names
MCC, WNT signaling pathway regulator
mutated in colorectal cancer
mutated in colorectal cancers

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    1668089..1827547 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021476719.2 → XP_021332394.1  colorectal mutant cancer protein isoform X2

    UniProtKB/TrEMBL
    A0A8M9Q5V7
    Related
    ENSDARP00000139720.2, ENSDART00000171193.2
    Conserved Domains (3) summary
    pfam04111
    Location:716 → 829
    APG6; Autophagy protein Apg6
    pfam10506
    Location:552 → 615
    MCC-bdg_PDZ; PDZ domain of MCC-2 bdg protein for Usher syndrome
    pfam13499
    Location:25 → 79
    EF-hand_7; EF-hand domain pair

  2. XM_021476718.2 → XP_021332393.1  colorectal mutant cancer protein isoform X1

    UniProtKB/TrEMBL
    A0A8M9PZA7
    Conserved Domains (4) summary
    pfam04111
    Location:754 → 867
    APG6; Autophagy protein Apg6
    pfam10506
    Location:590 → 653
    MCC-bdg_PDZ; PDZ domain of MCC-2 bdg protein for Usher syndrome
    pfam13499
    Location:25 → 79
    EF-hand_7; EF-hand domain pair
    cl25732
    Location:211 → 453
    SMC_N; RecF/RecN/SMC N terminal domain

  3. XM_021476720.2 → XP_021332395.1  colorectal mutant cancer protein isoform X3

    UniProtKB/TrEMBL
    A0A8M9QF20
    Conserved Domains (3) summary
    pfam04111
    Location:568 → 681
    APG6; Autophagy protein Apg6
    pfam10506
    Location:404 → 467
    MCC-bdg_PDZ; PDZ domain of MCC-2 bdg protein for Usher syndrome
    cl25732
    Location:25 → 267
    SMC_N; RecF/RecN/SMC N terminal domain
Nucleotide Protein Strain
Heading Accession and Version

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