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crispld2 cysteine-rich secretory protein LCCL domain containing 2 [ Danio rerio (zebrafish) ]

Gene ID: 100535149, updated on 2-Nov-2024

Summary

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Official Symbol
crispld2provided by ZNC
Official Full Name
cysteine-rich secretory protein LCCL domain containing 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-130131-1
See related
Ensembl:ENSDARG00000088595 AllianceGenome:ZFIN:ZDB-GENE-130131-1
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Acts upstream of or within face morphogenesis; roof of mouth development; and skeletal system development. Predicted to be located in extracellular region. Is expressed in head and pharynx. Used to study orofacial cleft. Orthologous to human CRISPLD2 (cysteine rich secretory protein LCCL domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information
Annotation category: partial on reference assembly
Orthologs
all
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Genomic context

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See crispld2 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (69081255..69121946, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (68832582..68870436)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene zinc finger homeobox 3b Neighboring gene uncharacterized LOC137496239 Neighboring gene hepatocyte nuclear factor 4-gamma-like Neighboring gene hepatic nuclear factor 4, beta Neighboring gene MARVEL domain containing 3 Neighboring gene ubiquitin specific peptidase 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Crispld2 is required for neural crest cell migration and cell viability during zebrafish craniofacial development. Swindell EC, et al. Genesis, 2015 Oct. PMID 26297922, Free PMC Article
  2. Craniofacial abnormalities result from knock down of nonsyndromic clefting gene, crispld2, in zebrafish. Yuan Q, et al. Genesis, 2012 Dec. PMID 22887593, Free PMC Article
  3. Knockdown of Crispld2 in zebrafish identifies a novel network for nonsyndromic cleft lip with or without cleft palate candidate genes. Chiquet BT, et al. Eur J Hum Genet, 2018 Oct. PMID 29899370, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. we demonstrated that knockdown of Crispld2 in zebrafish alters neural crest cell migration patterns resulting in abnormal jaw and palate development. In this study, we performed RNA profiling in zebrafish embryos and identified 249 differentially expressed genes following knockdown of Crispld2.
    Title: Knockdown of Crispld2 in zebrafish identifies a novel network for nonsyndromic cleft lip with or without cleft palate candidate genes.
  2. Results indicate an important role for Crispld2 protein in neural crest cells (NCCs) migration during craniofacial development and suggests involvement of Crispld2 in cell viability during formation of the orofacies.
    Title: Crispld2 is required for neural crest cell migration and cell viability during zebrafish craniofacial development.
  3. LOC100535149 knockdown leads to craniofacial abnormalities in zebrafish
    Title: Craniofacial abnormalities result from knock down of nonsyndromic clefting gene, crispld2, in zebrafish.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within cartilage morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryonic viscerocranium morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within face morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within roof of mouth development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cysteine-rich secretory protein LCCL domain-containing 2
Names
zmp:0000001254

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    69081255..69121946 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003199017.6 → XP_003199065.1  cysteine-rich secretory protein LCCL domain-containing 2

    UniProtKB/TrEMBL
    A0A8M1RM30
    Related
    ENSDARP00000110563.3, ENSDART00000130227.3
    Conserved Domains (3) summary
    smart00603
    Location:299 → 382
    LCCL; LCCL domain
    cd05380
    Location:61 → 206
    SCP_euk; SCP_euk: SCP-like extracellular protein domain, as found mainly in eukaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5 from vespid venom. It has been proposed ...
    pfam03815
    Location:402 → 495
    LCCL; LCCL domain
Nucleotide Protein Strain
Heading Accession and Version

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